ISMARA results: Xbp1

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GSE58827: Dynamics of the Mouse Liver

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Results for Xbp1_Creb3l1

Z-value: 1.20

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Transcription factors associated with Xbp1_Creb3l1

Gene Symbol	Gene ID	Gene Info
Xbp1 Ensembl NCBI MGI UniProt	ENSMUSG00000020484.20	X-box binding protein 1
Creb3l1 Ensembl NCBI MGI UniProt	ENSMUSG00000027230.10	cAMP responsive element binding protein 3-like 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Creb3l1	mm39_v1_chr2_-_91854844_91854847	0.48	2.9e-03	Click!
Xbp1	mm39_v1_chr11_+_5470968_5470996	0.47	3.9e-03	Click!

Activity profile of Xbp1_Creb3l1 motif

Sorted Z-values of Xbp1_Creb3l1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_-_44741622 Show fit	3.88	ENSMUST00000210469.2 ENSMUST00000211352.2 ENSMUST00000019683.11	Rcn3 Ensembl NCBI MGI UniProt Show fit	reticulocalbin 3, EF-hand calcium binding domain
chr7_-_44741609 Show fit	3.55	ENSMUST00000210734.2	Rcn3 Ensembl NCBI MGI UniProt Show fit	reticulocalbin 3, EF-hand calcium binding domain
chr10_+_128744689 Show fit	2.61	ENSMUST00000105229.9	Cd63 Ensembl NCBI MGI UniProt Show fit	CD63 antigen
chr10_+_128745214 Show fit	2.58	ENSMUST00000220308.2	Cd63 Ensembl NCBI MGI UniProt Show fit	CD63 antigen
chr1_-_93406091 Show fit	2.49	ENSMUST00000188165.2	Hdlbp Ensembl NCBI MGI UniProt Show fit	high density lipoprotein (HDL) binding protein
chr9_+_103940575 Show fit	2.42	ENSMUST00000120854.8	Acad11 Ensembl NCBI MGI UniProt Show fit	acyl-Coenzyme A dehydrogenase family, member 11
chr2_-_168584020 Show fit	2.39	ENSMUST00000109177.8	Atp9a Ensembl NCBI MGI UniProt Show fit	ATPase, class II, type 9A
chr9_-_86453862 Show fit	2.31	ENSMUST00000070064.11 ENSMUST00000072585.8	Pgm3 Ensembl NCBI MGI UniProt Show fit	phosphoglucomutase 3
chr15_+_79400597 Show fit	2.27	ENSMUST00000010974.9	Kdelr3 Ensembl NCBI MGI UniProt Show fit	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr19_+_32573182 Show fit	2.24	ENSMUST00000235594.2	Papss2 Ensembl NCBI MGI UniProt Show fit	3'-phosphoadenosine 5'-phosphosulfate synthase 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Xbp1_Creb3l1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.6	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.3	5.7	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.9	5.2	GO:2000680	regulation of rubidium ion transport(GO:2000680)
0.0	4.6	GO:0008203	cholesterol metabolic process(GO:0008203)
0.4	4.4	GO:0048208	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.5	3.8	GO:0071569	protein ufmylation(GO:0071569)
0.2	3.2	GO:0060510	Type II pneumocyte differentiation(GO:0060510)
0.5	2.6	GO:0034224	cellular response to zinc ion starvation(GO:0034224)
0.3	2.4	GO:0006621	protein retention in ER lumen(GO:0006621)
0.1	2.4	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)

Showing 1 to 10 of 71 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	28.6	GO:0005783	endoplasmic reticulum(GO:0005783)
1.7	5.2	GO:0031904	endosome lumen(GO:0031904)
0.3	5.0	GO:0030127	COPII vesicle coat(GO:0030127)
0.1	4.6	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.3	4.1	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	2.7	GO:0005802	trans-Golgi network(GO:0005802)
0.0	2.4	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.0	2.0	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	2.0	GO:0032587	ruffle membrane(GO:0032587)
0.1	1.6	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)

Showing 1 to 10 of 35 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	11.0	GO:0005509	calcium ion binding(GO:0005509)
0.0	6.4	GO:0000149	SNARE binding(GO:0000149)
0.0	6.4	GO:0045296	cadherin binding(GO:0045296)
0.1	4.1	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.1	3.8	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.1	3.5	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.1	2.6	GO:0003756	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.8	2.4	GO:0017099	very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.5	2.4	GO:0046923	ER retention sequence binding(GO:0046923)
0.4	2.3	GO:0004614	phosphoglucomutase activity(GO:0004614)

Showing 1 to 10 of 58 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.9	PID ARF 3PATHWAY	Arf1 pathway
0.0	1.9	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.0	1.3	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.0	0.9	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.8	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	0.6	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.5	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.0	0.5	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	0.4	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway

Showing 1 to 9 of 9 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.2	4.6	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1	4.1	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1	4.1	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.1	3.8	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.3	3.7	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.1	2.3	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2	2.2	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.1	2.2	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.1	1.8	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism

Showing 1 to 10 of 23 entries

Results for Xbp1_Creb3l1

Z-value: 1.20

Motif logo

Transcription factors associated with Xbp1_Creb3l1

Activity-expression correlation:

Activity profile of Xbp1_Creb3l1 motif

Sorted Z-values of Xbp1_Creb3l1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Xbp1_Creb3l1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: