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GSE58827: Dynamics of the Mouse Liver
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Results for Wrnip1_Mta3_Rcor1
Z-value: 2.02
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Transcription factors associated with Wrnip1_Mta3_Rcor1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rcor1 | mm39_v1_chr12_+_111005768_111005834 | -0.59 | 1.5e-04 | Click! |
| Wrnip1 | mm39_v1_chr13_+_32985990_32986135 | -0.36 | 3.3e-02 | Click! |
| Mta3 | mm39_v1_chr17_+_84013575_84013634 | -0.00 | 9.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_44983080 Show fit | 7.09 |
ENSMUST00000211743.2
ENSMUST00000042194.10 |
transient receptor potential cation channel, subfamily M, member 4 |
|
| chr4_-_137157824 Show fit | 6.75 |
ENSMUST00000102522.5
|
chymotrypsin-like elastase family, member 3B |
|
| chr1_-_119349969 Show fit | 6.53 |
ENSMUST00000038765.6
|
inhibin beta-B |
|
| chr13_-_63036096 Show fit | 6.50 |
ENSMUST00000092888.11
|
fructose bisphosphatase 1 |
|
| chr11_+_69945157 Show fit | 6.21 |
ENSMUST00000108585.9
ENSMUST00000018699.13 |
asialoglycoprotein receptor 1 |
|
| chr7_+_140343652 Show fit | 6.17 |
ENSMUST00000026552.9
ENSMUST00000209253.2 ENSMUST00000210235.2 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
|
| chr17_-_84990360 Show fit | 5.96 |
ENSMUST00000066175.10
|
ATP binding cassette subfamily G member 5 |
|
| chr1_-_171023798 Show fit | 5.91 |
ENSMUST00000111332.2
|
Purkinje cell protein 4-like 1 |
|
| chr8_-_112417633 Show fit | 5.73 |
ENSMUST00000034435.7
|
chymotrypsinogen B1 |
|
| chr1_+_171246593 Show fit | 5.63 |
ENSMUST00000171362.2
|
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Wrnip1_Mta3_Rcor1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 26.5 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) |
| 0.2 | 25.3 | GO:0030198 | extracellular matrix organization(GO:0030198) |
| 0.4 | 21.3 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.1 | 20.5 | GO:0006956 | complement activation(GO:0006956) |
| 0.6 | 16.5 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.5 | 15.9 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.9 | 15.5 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.6 | 15.4 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.3 | 13.6 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.3 | 13.6 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 264.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 67.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 62.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 57.7 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.2 | 41.4 | GO:0044391 | ribosomal subunit(GO:0044391) |
| 0.0 | 39.9 | GO:1903561 | extracellular vesicle(GO:1903561) |
| 0.9 | 22.9 | GO:0034361 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.2 | 22.7 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 20.4 | GO:0005912 | adherens junction(GO:0005912) |
| 0.1 | 18.7 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 78.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 37.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 31.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 25.7 | GO:0008201 | heparin binding(GO:0008201) |
| 0.5 | 23.7 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.6 | 20.1 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.3 | 18.7 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.2 | 17.7 | GO:0005178 | integrin binding(GO:0005178) |
| 0.3 | 17.0 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.1 | 16.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 114.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 51.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.6 | 45.8 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.2 | 34.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 22.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.6 | 21.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.5 | 19.6 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.3 | 18.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 18.8 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.3 | 15.0 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 34.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.3 | 29.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 24.8 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.8 | 22.8 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.4 | 18.9 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.9 | 18.4 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.4 | 17.9 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.4 | 17.9 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.2 | 17.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.6 | 17.6 | REACTOME AMYLOIDS | Genes involved in Amyloids |