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GSE58827: Dynamics of the Mouse Liver
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Results for Tfdp1_Wt1_Egr2
Z-value: 3.25
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Transcription factors associated with Tfdp1_Wt1_Egr2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tfdp1 | mm39_v1_chr8_+_13389656_13389674 | 0.92 | 1.6e-15 | Click! |
| Wt1 | mm39_v1_chr2_+_104961228_104961326 | 0.62 | 5.4e-05 | Click! |
| Egr2 | mm39_v1_chr10_+_67373691_67373760 | 0.46 | 4.5e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tfdp1_Wt1_Egr2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.1 | 73.2 | GO:2000467 | positive regulation of glycogen (starch) synthase activity(GO:2000467) |
| 2.0 | 68.2 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.7 | 65.8 | GO:0051028 | mRNA transport(GO:0051028) |
| 1.8 | 61.5 | GO:0046852 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
| 1.3 | 57.2 | GO:0006284 | base-excision repair(GO:0006284) |
| 1.5 | 54.7 | GO:0006779 | porphyrin-containing compound biosynthetic process(GO:0006779) |
| 0.8 | 44.6 | GO:1902850 | microtubule cytoskeleton organization involved in mitosis(GO:1902850) |
| 1.9 | 44.2 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 3.9 | 42.7 | GO:1902746 | regulation of lens fiber cell differentiation(GO:1902746) |
| 8.5 | 42.6 | GO:1902340 | telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 90.7 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 1.3 | 73.8 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.6 | 64.0 | GO:0016605 | PML body(GO:0016605) |
| 0.5 | 57.6 | GO:0032432 | actin filament bundle(GO:0032432) |
| 0.7 | 54.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.7 | 53.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 48.5 | GO:0005730 | nucleolus(GO:0005730) |
| 11.2 | 44.8 | GO:0001740 | Barr body(GO:0001740) |
| 2.7 | 43.9 | GO:0042555 | MCM complex(GO:0042555) |
| 0.5 | 42.6 | GO:0005905 | clathrin-coated pit(GO:0005905) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 230.3 | GO:0003723 | RNA binding(GO:0003723) |
| 1.0 | 146.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 2.2 | 91.8 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 1.8 | 74.3 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.4 | 68.4 | GO:0042393 | histone binding(GO:0042393) |
| 0.4 | 66.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 1.2 | 61.5 | GO:0097472 | cyclin-dependent protein kinase activity(GO:0097472) |
| 2.6 | 51.9 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 1.0 | 51.0 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.7 | 47.2 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 179.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.3 | 108.8 | PID E2F PATHWAY | E2F transcription factor network |
| 1.8 | 101.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.6 | 94.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.3 | 72.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.8 | 72.9 | PID NOTCH PATHWAY | Notch signaling pathway |
| 1.5 | 72.4 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 3.7 | 71.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 1.1 | 69.1 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 1.2 | 63.1 | PID IGF1 PATHWAY | IGF1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 107.3 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 3.8 | 91.6 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.7 | 81.5 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.8 | 79.8 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 4.9 | 78.3 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.9 | 73.2 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 1.9 | 72.7 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.8 | 63.6 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 2.8 | 62.5 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 3.0 | 59.3 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |