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GSE58827: Dynamics of the Mouse Liver
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Results for Tead3_Tead4
Z-value: 1.21
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Transcription factors associated with Tead3_Tead4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tead4 | mm39_v1_chr6_-_128277701_128277786 | 0.66 | 9.9e-06 | Click! |
| Tead3 | mm39_v1_chr17_-_28569574_28569685 | 0.56 | 3.6e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tead3_Tead4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 15.0 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 2.1 | 6.2 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation(GO:0035606) |
| 1.0 | 6.1 | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) |
| 0.0 | 5.9 | GO:0072659 | protein localization to plasma membrane(GO:0072659) |
| 0.6 | 5.8 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.9 | 5.6 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 0.4 | 5.6 | GO:0046549 | retinal cone cell development(GO:0046549) |
| 0.1 | 5.3 | GO:0032611 | interleukin-1 beta production(GO:0032611) |
| 0.9 | 4.4 | GO:0060931 | sinoatrial node cell development(GO:0060931) |
| 0.1 | 4.4 | GO:0032781 | positive regulation of ATPase activity(GO:0032781) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.5 | GO:0001726 | ruffle(GO:0001726) |
| 0.1 | 10.3 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 7.0 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 2.0 | 6.1 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 1.1 | 5.6 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.1 | 5.3 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 5.2 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 4.2 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.4 | 4.1 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.3 | 3.9 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 15.0 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.9 | 9.1 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.3 | 6.6 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.7 | 6.1 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.1 | 5.7 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.2 | 5.6 | GO:0030553 | cGMP binding(GO:0030553) |
| 0.1 | 4.5 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 4.4 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.4 | 4.0 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.6 | 3.8 | GO:0015232 | heme transporter activity(GO:0015232) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.2 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 7.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 6.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 5.9 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.1 | 5.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 5.0 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 4.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 4.2 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 2.6 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 2.6 | PID ENDOTHELIN PATHWAY | Endothelins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 15.0 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 7.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 3.9 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 3.9 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 3.4 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 3.1 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.2 | 2.9 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 2.7 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 2.5 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 2.5 | REACTOME PLATELET AGGREGATION PLUG FORMATION | Genes involved in Platelet Aggregation (Plug Formation) |