Project
GSE58827: Dynamics of the Mouse Liver
Navigation
Downloads
Results for Rela_Rel_Nfkb1
Z-value: 1.31
Motif logo
Transcription factors associated with Rela_Rel_Nfkb1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000024927.9 | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | |
| ENSMUSG00000020275.10 | reticuloendotheliosis oncogene | |
| ENSMUSG00000028163.18 | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfkb1 | mm39_v1_chr3_-_135373560_135373582 | 0.61 | 7.1e-05 | Click! |
| Rel | mm39_v1_chr11_-_23720953_23721028 | 0.50 | 1.9e-03 | Click! |
| Rela | mm39_v1_chr19_+_5687503_5687514 | 0.41 | 1.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Rela_Rel_Nfkb1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 7.0 | GO:0030573 | bile acid catabolic process(GO:0030573) |
| 0.4 | 4.9 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 1.1 | 4.5 | GO:1901740 | negative regulation of myoblast fusion(GO:1901740) |
| 1.1 | 4.3 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 0.8 | 4.2 | GO:0002901 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) |
| 0.1 | 4.2 | GO:0060396 | growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378) |
| 0.8 | 3.9 | GO:0034371 | chylomicron remodeling(GO:0034371) |
| 0.1 | 3.8 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.7 | 3.7 | GO:0097048 | dendritic cell apoptotic process(GO:0097048) regulation of dendritic cell apoptotic process(GO:2000668) |
| 1.1 | 3.4 | GO:0003365 | establishment of cell polarity involved in ameboidal cell migration(GO:0003365) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 5.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 4.3 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.3 | 3.6 | GO:0020005 | symbiont-containing vacuole membrane(GO:0020005) |
| 0.1 | 3.6 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 3.6 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.3 | 3.5 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.1 | 3.3 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 3.3 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 3.2 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 1.0 | 2.9 | GO:0005900 | oncostatin-M receptor complex(GO:0005900) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 7.0 | GO:0008396 | oxysterol 7-alpha-hydroxylase activity(GO:0008396) |
| 0.8 | 5.1 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.0 | 5.0 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.4 | 4.3 | GO:0030298 | receptor signaling protein tyrosine kinase activator activity(GO:0030298) CCR1 chemokine receptor binding(GO:0031726) |
| 0.7 | 4.2 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.8 | 3.9 | GO:0035478 | chylomicron binding(GO:0035478) |
| 0.7 | 3.9 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.2 | 3.8 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 3.7 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.0 | 3.5 | GO:0001047 | core promoter binding(GO:0001047) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.4 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 4.9 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 4.7 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 4.1 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 3.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 3.3 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 3.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 3.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.1 | ST GA12 PATHWAY | G alpha 12 Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.5 | 7.0 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.1 | 5.5 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.1 | 5.0 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 4.1 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 3.9 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 3.9 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 3.8 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 3.5 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 2.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |