ISMARA results: Nr1h4

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GSE58827: Dynamics of the Mouse Liver

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Results for Nr1h4

Z-value: 1.69

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Transcription factors associated with Nr1h4

Gene Symbol	Gene ID	Gene Info
Nr1h4 Ensembl NCBI MGI UniProt	ENSMUSG00000047638.16	nuclear receptor subfamily 1, group H, member 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Nr1h4	mm39_v1_chr10_-_89369432_89369452	0.88	7.9e-13	Click!

Activity profile of Nr1h4 motif

Sorted Z-values of Nr1h4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_-_93806593 Show fit	26.20	ENSMUST00000109582.3	Ces1b Ensembl NCBI MGI UniProt Show fit	carboxylesterase 1B
chr7_-_105249308 Show fit	19.15	ENSMUST00000210531.2 ENSMUST00000033185.10	Hpx Ensembl NCBI MGI UniProt Show fit	hemopexin
chr2_-_69172944 Show fit	17.26	ENSMUST00000102709.8 ENSMUST00000102710.10 ENSMUST00000180142.2	Abcb11 Ensembl NCBI MGI UniProt Show fit	ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr17_-_32639936 Show fit	15.15	ENSMUST00000170392.9 ENSMUST00000237165.2 ENSMUST00000235892.2 ENSMUST00000114455.3	Pglyrp2 Ensembl NCBI MGI UniProt Show fit	peptidoglycan recognition protein 2
chr9_-_65330231 Show fit	14.92	ENSMUST00000065894.7	Slc51b Ensembl NCBI MGI UniProt Show fit	solute carrier family 51, beta subunit
chr3_+_137983250 Show fit	14.64	ENSMUST00000004232.10	Adh1 Ensembl NCBI MGI UniProt Show fit	alcohol dehydrogenase 1 (class I)
chr4_+_133280680 Show fit	13.98	ENSMUST00000042706.3	Nr0b2 Ensembl NCBI MGI UniProt Show fit	nuclear receptor subfamily 0, group B, member 2
chr7_-_99345016 Show fit	13.85	ENSMUST00000107086.9	Slco2b1 Ensembl NCBI MGI UniProt Show fit	solute carrier organic anion transporter family, member 2b1
chr1_+_67162176 Show fit	13.59	ENSMUST00000027144.8	Cps1 Ensembl NCBI MGI UniProt Show fit	carbamoyl-phosphate synthetase 1
chr6_+_141575226 Show fit	13.14	ENSMUST00000042812.9	Slco1b2 Ensembl NCBI MGI UniProt Show fit	solute carrier organic anion transporter family, member 1b2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr1h4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	24.5	GO:0006751	glutathione catabolic process(GO:0006751)
0.4	23.8	GO:1900047	negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
3.7	22.1	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
2.7	19.2	GO:0060332	positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) heme transport(GO:0015886) positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
1.6	18.1	GO:1903797	positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278) positive regulation of inorganic anion transmembrane transport(GO:1903797)
0.3	17.4	GO:0019369	arachidonic acid metabolic process(GO:0019369)
2.5	17.3	GO:0046618	drug export(GO:0046618)
1.1	16.7	GO:0006957	complement activation, alternative pathway(GO:0006957)
4.2	16.6	GO:0010901	regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
2.5	15.1	GO:0000270	peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253) negative regulation of natural killer cell differentiation(GO:0032824) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)

Showing 1 to 10 of 100 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	61.3	GO:0072562	blood microparticle(GO:0072562)
0.2	22.1	GO:0005778	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
1.0	17.3	GO:0046581	intercellular canaliculus(GO:0046581)
0.7	16.6	GO:0042627	chylomicron(GO:0042627)
0.2	14.5	GO:0034707	chloride channel complex(GO:0034707)
0.2	13.9	GO:0009925	basal plasma membrane(GO:0009925)
0.2	13.6	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0	12.1	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	11.6	GO:0005740	mitochondrial envelope(GO:0005740)
0.0	10.0	GO:0031225	anchored component of membrane(GO:0031225)

Showing 1 to 10 of 45 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	44.2	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.2	33.9	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	33.3	GO:0004866	endopeptidase inhibitor activity(GO:0004866)
0.1	25.7	GO:0052689	carboxylic ester hydrolase activity(GO:0052689)
2.0	24.5	GO:0036374	glutathione hydrolase activity(GO:0036374)
3.2	22.1	GO:0016401	palmitoyl-CoA oxidase activity(GO:0016401)
3.2	19.2	GO:0015232	heme transporter activity(GO:0015232)
0.2	18.1	GO:0017080	sodium channel regulator activity(GO:0017080)
0.3	17.4	GO:0008395	steroid hydroxylase activity(GO:0008395)
2.5	15.1	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) peptidoglycan receptor activity(GO:0016019)

Showing 1 to 10 of 82 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	38.0	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.1	22.4	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.6	16.9	ST G ALPHA S PATHWAY	G alpha s Pathway
0.1	15.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	12.4	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.1	5.1	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0	2.2	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	2.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	1.9	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.2	1.6	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network

Showing 1 to 10 of 14 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	25.1	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.9	22.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.6	16.6	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.2	15.9	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
1.4	15.0	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
1.2	13.9	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	12.4	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.5	11.3	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.8	11.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.5	7.9	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle

Showing 1 to 10 of 35 entries

Results for Nr1h4

Z-value: 1.69

Motif logo

Transcription factors associated with Nr1h4

Activity-expression correlation:

Activity profile of Nr1h4 motif

Sorted Z-values of Nr1h4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr1h4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: