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GSE58827: Dynamics of the Mouse Liver
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Results for Nfic_Nfib
Z-value: 1.52
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Transcription factors associated with Nfic_Nfib
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfib | mm39_v1_chr4_-_82623972_82623997 | 0.39 | 1.8e-02 | Click! |
| Nfic | mm39_v1_chr10_-_81243475_81243515 | 0.28 | 9.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_109678685 Show fit | 11.01 |
ENSMUST00000112022.5
|
cathelicidin antimicrobial peptide |
|
| chrX_+_135171002 Show fit | 9.98 |
ENSMUST00000178632.8
ENSMUST00000053540.11 |
brain expressed X-linked 3 |
|
| chr5_-_145742672 Show fit | 9.41 |
ENSMUST00000067479.6
|
cytochrome P450, family 3, subfamily a, polypeptide 44 |
|
| chrX_+_135171049 Show fit | 8.62 |
ENSMUST00000113112.2
|
brain expressed X-linked 3 |
|
| chr5_-_145521533 Show fit | 8.38 |
ENSMUST00000075837.8
|
cytochrome P450, family 3, subfamily a, polypeptide 41B |
|
| chr8_+_95710977 Show fit | 8.33 |
ENSMUST00000093271.8
|
adhesion G protein-coupled receptor G1 |
|
| chr3_-_107129038 Show fit | 7.25 |
ENSMUST00000029504.9
|
chymosin |
|
| chr11_+_61376257 Show fit | 6.84 |
ENSMUST00000064783.10
ENSMUST00000040522.7 |
microfibrillar-associated protein 4 |
|
| chr7_+_46700349 Show fit | 6.78 |
ENSMUST00000010451.8
|
transmembrane protein 86A |
|
| chr3_+_90576285 Show fit | 6.59 |
ENSMUST00000069927.10
|
S100 calcium binding protein A8 (calgranulin A) |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nfic_Nfib
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.4 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) |
| 0.6 | 15.5 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.8 | 12.6 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 3.1 | 12.3 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
| 1.4 | 10.9 | GO:1900147 | Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147) |
| 2.0 | 9.9 | GO:0019074 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 1.8 | 8.8 | GO:0072138 | mesenchymal cell proliferation involved in ureteric bud development(GO:0072138) |
| 0.1 | 7.7 | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway(GO:0017015) |
| 0.6 | 6.8 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 1.6 | 6.6 | GO:0070488 | neutrophil aggregation(GO:0070488) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 16.3 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 1.4 | 15.5 | GO:0097451 | glial limiting end-foot(GO:0097451) |
| 0.1 | 11.6 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 11.2 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 1.0 | 10.9 | GO:0045098 | type III intermediate filament(GO:0045098) |
| 2.1 | 10.7 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.4 | 10.6 | GO:0042581 | specific granule(GO:0042581) |
| 0.1 | 9.8 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 7.6 | GO:0000139 | Golgi membrane(GO:0000139) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.1 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.7 | 18.0 | GO:0005123 | death receptor binding(GO:0005123) |
| 2.2 | 17.8 | GO:0050649 | testosterone 6-beta-hydroxylase activity(GO:0050649) |
| 0.1 | 11.2 | GO:0004386 | helicase activity(GO:0004386) |
| 1.8 | 10.9 | GO:1990254 | keratin filament binding(GO:1990254) |
| 2.5 | 9.9 | GO:0004736 | pyruvate carboxylase activity(GO:0004736) |
| 0.3 | 8.8 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.2 | 7.3 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) |
| 0.1 | 7.3 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.3 | 7.2 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 11.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 11.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 11.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.2 | 11.0 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.1 | 8.9 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.2 | 6.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 5.2 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 4.7 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 4.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.0 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.3 | 12.3 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.3 | 10.5 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.4 | 9.5 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 9.3 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.3 | 5.9 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 5.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.3 | 4.8 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.1 | 4.7 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.1 | 4.5 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |