Project
GSE58827: Dynamics of the Mouse Liver
Navigation
Downloads
Results for Mef2d_Mef2a
Z-value: 1.65
Motif logo
Transcription factors associated with Mef2d_Mef2a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mef2d | mm39_v1_chr3_+_88049633_88049790 | -0.35 | 3.6e-02 | Click! |
| Mef2a | mm39_v1_chr7_-_67022520_67022609 | -0.24 | 1.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Mef2d_Mef2a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 25.2 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.1 | 24.1 | GO:0060048 | cardiac muscle contraction(GO:0060048) |
| 0.4 | 19.7 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 4.5 | 13.5 | GO:0042694 | muscle cell fate specification(GO:0042694) |
| 0.3 | 12.7 | GO:0010866 | regulation of triglyceride biosynthetic process(GO:0010866) |
| 1.3 | 12.1 | GO:0061709 | reticulophagy(GO:0061709) |
| 1.4 | 11.3 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 1.8 | 10.9 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 1.1 | 9.5 | GO:0038033 | positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033) |
| 1.4 | 8.6 | GO:0035995 | detection of muscle stretch(GO:0035995) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.3 | GO:0030018 | Z disc(GO:0030018) |
| 1.3 | 25.5 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 1.5 | 19.4 | GO:0005861 | troponin complex(GO:0005861) |
| 0.2 | 18.4 | GO:0016459 | myosin complex(GO:0016459) |
| 0.6 | 15.3 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.2 | 12.1 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 11.3 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 9.0 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 1.1 | 8.7 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 2.6 | 7.8 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 28.5 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 27.5 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.3 | 15.5 | GO:0003785 | actin monomer binding(GO:0003785) |
| 2.7 | 13.7 | GO:0051373 | FATZ binding(GO:0051373) |
| 1.3 | 13.3 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.2 | 9.5 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 1.5 | 6.1 | GO:0031433 | telethonin binding(GO:0031433) |
| 1.2 | 6.1 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.1 | 5.8 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 1.4 | 5.5 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 13.5 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.2 | 10.8 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.1 | 9.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 5.8 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.1 | 4.3 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 3.8 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 3.8 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 2.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 2.7 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 2.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 66.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 9.5 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.6 | 6.1 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 5.9 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 4.7 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 4.0 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.2 | 3.7 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.1 | 3.6 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 3.4 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 2.8 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |