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GSE58827: Dynamics of the Mouse Liver
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Results for Irf3
Z-value: 1.18
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Transcription factors associated with Irf3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Irf3 | mm39_v1_chr7_+_44647072_44647126 | 0.24 | 1.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Irf3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 23.0 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
| 1.9 | 5.8 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.7 | 5.5 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.0 | 4.4 | GO:0051607 | defense response to virus(GO:0051607) |
| 0.4 | 4.3 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 0.1 | 4.3 | GO:0019884 | antigen processing and presentation of exogenous antigen(GO:0019884) |
| 0.3 | 3.8 | GO:0060340 | positive regulation of type I interferon-mediated signaling pathway(GO:0060340) |
| 0.6 | 3.4 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.9 | 2.8 | GO:0061762 | CAMKK-AMPK signaling cascade(GO:0061762) |
| 0.1 | 2.5 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.7 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.5 | 7.5 | GO:0020003 | symbiont-containing vacuole(GO:0020003) |
| 0.7 | 5.8 | GO:0042825 | TAP complex(GO:0042825) |
| 0.8 | 4.7 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.2 | 2.5 | GO:0044754 | autolysosome(GO:0044754) |
| 0.0 | 2.3 | GO:0016605 | PML body(GO:0016605) |
| 0.2 | 1.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 1.0 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.2 | 0.8 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.1 | 0.4 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.5 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.0 | 11.5 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 1.9 | 5.8 | GO:0046980 | peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980) |
| 0.3 | 5.5 | GO:0031386 | protein tag(GO:0031386) |
| 0.5 | 5.0 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 1.3 | 3.8 | GO:0003692 | left-handed Z-DNA binding(GO:0003692) |
| 0.3 | 2.8 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.0 | 2.7 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.4 | 2.5 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 0.5 | 2.3 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 3.4 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.7 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.8 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 1.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 1.4 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 1.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.0 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 0.5 | PID S1P S1P4 PATHWAY | S1P4 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 5.4 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.2 | 4.6 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 3.8 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.0 | 2.6 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 0.1 | 2.1 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 1.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.0 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.0 | 0.5 | REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
| 0.0 | 0.2 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |