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GSE58827: Dynamics of the Mouse Liver
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Results for Hcfc1_Six5_Smarcc2_Zfp143
Z-value: 3.00
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Transcription factors associated with Hcfc1_Six5_Smarcc2_Zfp143
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000031386.15 | host cell factor C1 | |
| ENSMUSG00000040841.6 | sine oculis-related homeobox 5 | |
| ENSMUSG00000025369.16 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | |
| ENSMUSG00000061079.15 | zinc finger protein 143 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zfp143 | mm39_v1_chr7_+_109660887_109660950 | 0.79 | 9.4e-09 | Click! |
| Hcfc1 | mm39_v1_chrX_-_73009933_73009982 | 0.74 | 3.1e-07 | Click! |
| Smarcc2 | mm39_v1_chr10_+_128295159_128295197 | 0.60 | 1.0e-04 | Click! |
| Six5 | mm39_v1_chr7_+_18828519_18828558 | 0.18 | 2.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hcfc1_Six5_Smarcc2_Zfp143
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 54.1 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.3 | 47.2 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.1 | 41.8 | GO:0008380 | RNA splicing(GO:0008380) |
| 3.5 | 27.6 | GO:0033567 | DNA replication, Okazaki fragment processing(GO:0033567) |
| 3.4 | 20.5 | GO:0030423 | targeting of mRNA for destruction involved in RNA interference(GO:0030423) |
| 0.2 | 19.3 | GO:0007051 | spindle organization(GO:0007051) |
| 1.0 | 18.3 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
| 0.6 | 18.2 | GO:1990126 | retrograde transport, endosome to plasma membrane(GO:1990126) |
| 3.4 | 17.0 | GO:0051754 | meiotic sister chromatid cohesion, centromeric(GO:0051754) |
| 2.4 | 16.9 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 33.7 | GO:0005829 | cytosol(GO:0005829) |
| 0.6 | 27.9 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.3 | 25.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 24.7 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.3 | 24.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 1.8 | 23.6 | GO:0005818 | aster(GO:0005818) |
| 0.3 | 22.5 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.2 | 21.8 | GO:0000922 | spindle pole(GO:0000922) |
| 1.5 | 19.1 | GO:0000778 | condensed nuclear chromosome kinetochore(GO:0000778) |
| 0.0 | 17.8 | GO:0005813 | centrosome(GO:0005813) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 51.3 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.8 | 37.6 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 27.0 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.2 | 26.7 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.2 | 21.2 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.1 | 21.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 17.4 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.0 | 17.3 | GO:0003723 | RNA binding(GO:0003723) |
| 1.8 | 16.4 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 0.0 | 15.6 | GO:0019904 | protein domain specific binding(GO:0019904) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 67.2 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.8 | 38.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.5 | 26.5 | PID ATR PATHWAY | ATR signaling pathway |
| 0.5 | 18.1 | PID MYC PATHWAY | C-MYC pathway |
| 0.4 | 18.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 12.7 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 10.1 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.2 | 9.6 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.4 | 9.4 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 8.4 | PID P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 69.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.4 | 58.4 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 1.6 | 33.6 | REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | Genes involved in Processive synthesis on the lagging strand |
| 1.1 | 30.5 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 0.3 | 20.7 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 0.9 | 20.4 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.7 | 16.4 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.5 | 14.7 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.6 | 13.7 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.1 | 12.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |