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GSE58827: Dynamics of the Mouse Liver
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Results for Gli3_Zic1
Z-value: 0.99
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Transcription factors associated with Gli3_Zic1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Gli3 | mm39_v1_chr13_+_15638466_15638565 | 0.41 | 1.4e-02 | Click! |
| Zic1 | mm39_v1_chr9_-_91247831_91247868 | 0.09 | 6.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Gli3_Zic1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.2 | GO:2000467 | positive regulation of glycogen (starch) synthase activity(GO:2000467) |
| 0.2 | 6.1 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 1.3 | 4.0 | GO:0006571 | tyrosine biosynthetic process(GO:0006571) aromatic amino acid family biosynthetic process(GO:0009073) aromatic amino acid family biosynthetic process, prephenate pathway(GO:0009095) |
| 0.1 | 3.4 | GO:0000731 | DNA synthesis involved in DNA repair(GO:0000731) |
| 0.7 | 3.3 | GO:0048807 | female genitalia morphogenesis(GO:0048807) |
| 0.1 | 2.5 | GO:0021692 | cerebellar Purkinje cell layer morphogenesis(GO:0021692) |
| 0.8 | 2.4 | GO:0042323 | regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) |
| 0.4 | 2.4 | GO:0030421 | defecation(GO:0030421) |
| 0.2 | 2.4 | GO:0042760 | very long-chain fatty acid catabolic process(GO:0042760) |
| 0.3 | 2.3 | GO:0055095 | lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.0 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 4.1 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.8 | 3.8 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.4 | 2.9 | GO:0008091 | spectrin(GO:0008091) |
| 0.1 | 2.5 | GO:0098984 | neuron to neuron synapse(GO:0098984) |
| 0.0 | 2.4 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.1 | 2.3 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 2.3 | GO:0032432 | actin filament bundle(GO:0032432) |
| 0.4 | 1.7 | GO:0097447 | dendritic tree(GO:0097447) |
| 0.2 | 1.7 | GO:1990761 | growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.5 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.1 | 6.2 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.6 | 6.1 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.7 | 4.0 | GO:0004505 | phenylalanine 4-monooxygenase activity(GO:0004505) |
| 0.1 | 3.8 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 1.2 | 3.6 | GO:0034632 | retinol transporter activity(GO:0034632) |
| 0.0 | 3.0 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.3 | 2.4 | GO:0032795 | heterotrimeric G-protein binding(GO:0032795) |
| 0.1 | 2.3 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.7 | 2.2 | GO:0035939 | microsatellite binding(GO:0035939) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.3 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 4.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.8 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 2.4 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 2.0 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 2.0 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 1.8 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 1.4 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 0.9 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.9 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 12.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.3 | 3.8 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 3.7 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 2.9 | REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH | Genes involved in NCAM signaling for neurite out-growth |
| 0.0 | 2.7 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 2.4 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 2.3 | REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.1 | 2.3 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 2.2 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.1 | 2.0 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |