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GSE58827: Dynamics of the Mouse Liver
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Results for Foxa2_Foxa1
Z-value: 1.85
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Transcription factors associated with Foxa2_Foxa1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxa2 | mm39_v1_chr2_-_147888816_147888912 | 0.82 | 1.1e-09 | Click! |
| Foxa1 | mm39_v1_chr12_-_57592907_57592926 | 0.51 | 1.3e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Foxa2_Foxa1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 33.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 3.3 | 23.0 | GO:0060455 | negative regulation of gastric acid secretion(GO:0060455) |
| 0.8 | 22.8 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 5.7 | 22.7 | GO:0010901 | regulation of very-low-density lipoprotein particle remodeling(GO:0010901) |
| 0.4 | 21.5 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 1.2 | 18.9 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.5 | 16.6 | GO:0046688 | response to copper ion(GO:0046688) |
| 3.2 | 16.1 | GO:0051919 | positive regulation of fibrinolysis(GO:0051919) |
| 0.6 | 16.0 | GO:0017144 | drug metabolic process(GO:0017144) |
| 1.1 | 15.4 | GO:0006642 | triglyceride mobilization(GO:0006642) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 107.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 37.1 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 1.1 | 22.7 | GO:0042627 | chylomicron(GO:0042627) |
| 0.3 | 19.2 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.7 | 18.9 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 1.9 | 18.5 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.1 | 14.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 14.4 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 1.1 | 13.9 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 4.5 | 13.5 | GO:0034359 | mature chylomicron(GO:0034359) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 42.3 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.2 | 29.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 3.6 | 25.3 | GO:0004556 | alpha-amylase activity(GO:0004556) |
| 1.7 | 23.1 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 3.4 | 20.3 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.5 | 19.4 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.3 | 19.2 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.9 | 18.9 | GO:0030957 | Tat protein binding(GO:0030957) |
| 2.2 | 17.7 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.1 | 16.7 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 21.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 15.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 12.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 11.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 10.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 9.3 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 8.6 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 7.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 6.1 | PID FGF PATHWAY | FGF signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 36.1 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.5 | 31.9 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 18.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 1.6 | 17.7 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.8 | 17.6 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 5.3 | 16.0 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.4 | 15.3 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.3 | 15.0 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.5 | 14.3 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.7 | 13.5 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |