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GSE58827: Dynamics of the Mouse Liver
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Results for Etv1_Etv5_Gabpa
Z-value: 1.46
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Transcription factors associated with Etv1_Etv5_Gabpa
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Etv1 | mm39_v1_chr12_+_38833454_38833482 | -0.47 | 3.6e-03 | Click! |
| Gabpa | mm39_v1_chr16_+_84631789_84631843 | -0.29 | 8.5e-02 | Click! |
| Etv5 | mm39_v1_chr16_-_22258469_22258484 | -0.29 | 8.7e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Etv1_Etv5_Gabpa
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 27.2 | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.3 | 20.4 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.4 | 18.6 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.4 | 17.0 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.7 | 15.9 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.6 | 11.9 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 0.4 | 10.8 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 1.7 | 10.3 | GO:0045905 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.1 | 10.3 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.2 | 9.7 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 51.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.7 | 41.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 19.4 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 17.9 | GO:0005730 | nucleolus(GO:0005730) |
| 0.4 | 14.5 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 1.0 | 12.5 | GO:0005687 | U4 snRNP(GO:0005687) |
| 0.6 | 10.5 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.1 | 10.4 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.3 | 9.8 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.7 | 9.5 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 95.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 21.5 | GO:0003723 | RNA binding(GO:0003723) |
| 0.2 | 18.1 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.2 | 14.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.7 | 12.2 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.8 | 9.9 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.2 | 9.2 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.1 | 8.4 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 8.1 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.4 | 6.9 | GO:0031386 | protein tag(GO:0031386) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.3 | 11.8 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.2 | 11.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 7.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 7.1 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 4.8 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.0 | 4.3 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 3.9 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 3.9 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 3.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 51.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.7 | 51.2 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.3 | 20.4 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.2 | 18.9 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
| 0.7 | 14.2 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.4 | 13.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.2 | 12.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 12.0 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.9 | 11.9 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.2 | 11.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |