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GSE58827: Dynamics of the Mouse Liver
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Results for Erg
Z-value: 2.95
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Transcription factors associated with Erg
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Erg | mm39_v1_chr16_-_95260104_95260243 | 0.77 | 3.7e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Erg
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 26.8 | 80.4 | GO:0002148 | hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149) |
| 1.6 | 40.7 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 13.1 | 39.4 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation(GO:0035606) |
| 0.3 | 29.2 | GO:0030168 | platelet activation(GO:0030168) |
| 1.7 | 28.7 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.2 | 21.5 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.5 | 21.4 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.2 | 20.4 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.2 | 19.2 | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189) |
| 0.3 | 18.1 | GO:0035411 | catenin import into nucleus(GO:0035411) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 78.7 | GO:0005766 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.6 | 41.3 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 27.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 1.5 | 25.7 | GO:0001931 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.2 | 25.2 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.4 | 23.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 1.7 | 22.4 | GO:0031091 | platelet alpha granule(GO:0031091) |
| 1.3 | 19.9 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.2 | 18.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.3 | 16.9 | GO:0002102 | podosome(GO:0002102) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 79.3 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.4 | 56.0 | GO:0004540 | ribonuclease activity(GO:0004540) |
| 5.0 | 50.4 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.7 | 41.4 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.2 | 36.2 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 31.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.4 | 28.7 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.4 | 27.6 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.3 | 21.5 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 1.5 | 19.9 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 79.1 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.6 | 63.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.8 | 47.9 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.6 | 44.7 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.7 | 39.9 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.9 | 31.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 31.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 31.2 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.6 | 22.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.5 | 20.0 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 45.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.6 | 40.7 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.5 | 31.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 1.8 | 29.3 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.3 | 28.7 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.6 | 28.3 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 23.8 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.4 | 23.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.1 | 22.9 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.3 | 20.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |