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GSE58827: Dynamics of the Mouse Liver
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Results for Ebf1
Z-value: 1.55
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Transcription factors associated with Ebf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ebf1 | mm39_v1_chr11_+_44508137_44508169 | 0.72 | 6.1e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ebf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 16.1 | GO:0051873 | disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873) |
| 0.1 | 14.6 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 4.8 | 14.4 | GO:0002215 | defense response to nematode(GO:0002215) |
| 1.8 | 14.2 | GO:0032796 | uropod organization(GO:0032796) |
| 0.1 | 13.8 | GO:0030168 | platelet activation(GO:0030168) |
| 1.4 | 12.8 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.4 | 11.9 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.4 | 11.7 | GO:0046685 | response to arsenic-containing substance(GO:0046685) |
| 1.1 | 11.6 | GO:0030886 | negative regulation of myeloid dendritic cell activation(GO:0030886) |
| 2.3 | 11.5 | GO:0097029 | mature conventional dendritic cell differentiation(GO:0097029) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.2 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 13.4 | GO:0019814 | immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571) |
| 0.5 | 12.6 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.5 | 12.2 | GO:0042581 | specific granule(GO:0042581) |
| 1.6 | 11.5 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.5 | 10.9 | GO:0031091 | platelet alpha granule(GO:0031091) |
| 0.1 | 10.7 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.1 | 10.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 10.1 | GO:0005819 | spindle(GO:0005819) |
| 0.0 | 10.1 | GO:0005635 | nuclear envelope(GO:0005635) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.8 | 17.3 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.1 | 16.6 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 15.2 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.1 | 13.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 13.2 | GO:0042393 | histone binding(GO:0042393) |
| 0.5 | 11.5 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.2 | 11.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.5 | 11.3 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.2 | 11.2 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 26.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 23.4 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.3 | 13.4 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 1.3 | 13.2 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.3 | 12.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 10.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.2 | 10.4 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.2 | 10.2 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.2 | 9.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 8.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.1 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 17.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 13.9 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.6 | 12.8 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.2 | 12.4 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 11.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 10.5 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.2 | 10.4 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.4 | 9.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 8.6 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |