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GSE58827: Dynamics of the Mouse Liver

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Results for Bbx

Z-value: 0.32

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Transcription factors associated with Bbx

Gene Symbol Gene ID Gene Info
Bbx
ENSMUSG00000022641.16 bobby sox HMG box containing

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Bbxmm39_v1_chr16_-_50252703_502527720.298.9e-02Click!

Activity profile of Bbx motif

Sorted Z-values of Bbx motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_41121979 4.20 ENSMUST00000024721.8
ENSMUST00000233740.2
Rhag
Rhesus blood group-associated A glycoprotein
chr12_+_103354915 2.45 ENSMUST00000101094.9
ENSMUST00000021620.13
Otub2
OTU domain, ubiquitin aldehyde binding 2
chrX_-_149597261 2.39 ENSMUST00000026302.13
ENSMUST00000129768.8
ENSMUST00000112699.9
Maged2
MAGE family member D2
chr1_-_144651157 1.29 ENSMUST00000027603.4
Rgs18
regulator of G-protein signaling 18
chr2_-_152672535 1.14 ENSMUST00000146380.2
ENSMUST00000134902.2
ENSMUST00000134357.2
ENSMUST00000109820.5
Bcl2l1
BCL2-like 1
chr2_-_152672185 1.03 ENSMUST00000140436.2
Bcl2l1
BCL2-like 1
chr8_+_71069476 1.03 ENSMUST00000052437.6
Lrrc25
leucine rich repeat containing 25
chr10_+_85858050 0.89 ENSMUST00000120344.8
ENSMUST00000117597.2
Fbxo7
F-box protein 7
chr10_+_85857726 0.76 ENSMUST00000130320.8
Fbxo7
F-box protein 7
chr15_-_80929669 0.71 ENSMUST00000135047.2
Mrtfa
myocardin related transcription factor A
chr17_+_57665691 0.69 ENSMUST00000086763.13
ENSMUST00000233376.2
ENSMUST00000233840.2
ENSMUST00000232808.2
ENSMUST00000004850.8
Adgre1
adhesion G protein-coupled receptor E1
chr13_-_52685305 0.60 ENSMUST00000057442.8
Diras2
DIRAS family, GTP-binding RAS-like 2
chrX_+_158491589 0.55 ENSMUST00000080394.13
Sh3kbp1
SH3-domain kinase binding protein 1
chr7_-_97970388 0.44 ENSMUST00000120520.8
Acer3
alkaline ceramidase 3
chr10_+_58207229 0.43 ENSMUST00000238939.2
Lims1
LIM and senescent cell antigen-like domains 1
chr15_-_11907267 0.33 ENSMUST00000228489.2
Npr3
natriuretic peptide receptor 3
chr13_-_98152768 0.32 ENSMUST00000238746.2
Arhgef28
Rho guanine nucleotide exchange factor (GEF) 28
chr15_-_50746202 0.29 ENSMUST00000184885.8
Trps1
transcriptional repressor GATA binding 1
chr13_-_91955781 0.27 ENSMUST00000022121.13
Zcchc9
zinc finger, CCHC domain containing 9
chr12_-_86125793 0.27 ENSMUST00000003687.8
Tgfb3
transforming growth factor, beta 3
chr13_+_46655324 0.26 ENSMUST00000021802.16
Cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr16_+_20511991 0.25 ENSMUST00000149543.9
ENSMUST00000232207.2
ENSMUST00000118919.9
Fam131a
family with sequence similarity 131, member A
chr6_+_67890534 0.19 ENSMUST00000197406.5
ENSMUST00000103311.3
Igkv11-125
immunoglobulin kappa variable 11-125
chr9_-_38585897 0.18 ENSMUST00000215461.3
Olfr918
olfactory receptor 918
chr11_-_79418500 0.15 ENSMUST00000154415.2
Evi2a
ecotropic viral integration site 2a
chr10_-_89270554 0.14 ENSMUST00000220071.2
Gas2l3
growth arrest-specific 2 like 3
chr18_-_60724855 0.12 ENSMUST00000056533.9
Myoz3
myozenin 3
chr3_-_37286714 0.12 ENSMUST00000161015.2
ENSMUST00000029273.8
Il21
interleukin 21
chr11_-_87788066 0.11 ENSMUST00000217095.2
ENSMUST00000215150.2
Olfr463
olfactory receptor 463
chr13_-_65200204 0.11 ENSMUST00000222769.2
Prss47
protease, serine 47
chr10_-_44334683 0.11 ENSMUST00000105490.3
Prdm1
PR domain containing 1, with ZNF domain
chr2_-_155434487 0.10 ENSMUST00000155347.2
ENSMUST00000130881.8
ENSMUST00000079691.13
Gss
glutathione synthetase
chr10_-_129741736 0.09 ENSMUST00000216182.2
Olfr815
olfactory receptor 815
chr13_+_49761506 0.09 ENSMUST00000021822.7
Ogn
osteoglycin
chr15_+_30457772 0.07 ENSMUST00000228282.2
Ctnnd2
catenin (cadherin associated protein), delta 2
chr12_-_115944754 0.06 ENSMUST00000103551.2
Ighv1-84
immunoglobulin heavy variable 1-84
chrX_+_67805443 0.06 ENSMUST00000069731.12
ENSMUST00000114647.8
Fmr1nb
Fmr1 neighbor
chr10_-_44334711 0.04 ENSMUST00000039174.11
Prdm1
PR domain containing 1, with ZNF domain
chr2_+_87185159 0.03 ENSMUST00000215163.3
Olfr1120
olfactory receptor 1120
chrX_-_106859842 0.03 ENSMUST00000120722.2
2610002M06Rik
RIKEN cDNA 2610002M06 gene
chr14_+_53775648 0.03 ENSMUST00000200115.2
ENSMUST00000103650.3
Trav12-1
T cell receptor alpha variable 12-1
chr10_-_89270527 0.02 ENSMUST00000218764.2
Gas2l3
growth arrest-specific 2 like 3
chr18_-_66103308 0.01 ENSMUST00000025397.7
Cplx4
complexin 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Bbx

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.5 2.2 GO:0046898 response to cycloheximide(GO:0046898)
0.3 2.4 GO:0070294 renal sodium ion absorption(GO:0070294)
0.2 2.5 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.1 1.7 GO:1903599 positive regulation of mitophagy(GO:1903599)
0.1 0.3 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.1 GO:0033082 regulation of extrathymic T cell differentiation(GO:0033082)
0.0 0.4 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 0.3 GO:0002158 osteoclast proliferation(GO:0002158)
0.0 0.4 GO:0046512 sphingosine biosynthetic process(GO:0046512)
0.0 0.1 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.0 0.3 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:1990037 Lewy body core(GO:1990037)
0.2 2.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.2 2.2 GO:0051434 BH3 domain binding(GO:0051434)
0.2 4.2 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.1 0.3 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.4 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.3 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.1 GO:0051373 FATZ binding(GO:0051373)
0.0 0.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 1.7 GO:0043130 ubiquitin binding(GO:0043130)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.2 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 2.2 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.6 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation