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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Ybx1_Nfya_Nfyb_Nfyc_Cebpz
Z-value: 8.39
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Transcription factors associated with Ybx1_Nfya_Nfyb_Nfyc_Cebpz
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000028639.15 | Ybx1 | |
| ENSMUSG00000023994.14 | Nfya | |
| ENSMUSG00000020248.19 | Nfyb | |
| ENSMUSG00000032897.18 | Nfyc | |
| ENSMUSG00000024081.10 | Cebpz |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfyc | mm39_v1_chr4_-_120672900_120672959 | 0.84 | 9.6e-11 | Click! |
| Nfya | mm39_v1_chr17_-_48716756_48716934 | 0.81 | 3.0e-09 | Click! |
| Ybx1 | mm39_v1_chr4_-_119151717_119151801 | 0.75 | 1.4e-07 | Click! |
| Nfyb | mm39_v1_chr10_-_82599967_82599991 | 0.55 | 4.9e-04 | Click! |
| Cebpz | mm39_v1_chr17_-_79244460_79244504 | 0.39 | 2.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ybx1_Nfya_Nfyb_Nfyc_Cebpz
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_84682136 Show fit | 68.31 |
ENSMUST00000005607.9
|
anti-silencing function 1B histone chaperone |
|
| chr6_+_124806541 Show fit | 61.81 |
ENSMUST00000024270.14
|
cell division cycle associated 3 |
|
| chr11_-_98915005 Show fit | 61.07 |
ENSMUST00000068031.8
|
topoisomerase (DNA) II alpha |
|
| chr6_-_86646118 Show fit | 50.56 |
ENSMUST00000001184.10
|
MAX dimerization protein 1 |
|
| chr11_-_86999481 Show fit | 50.54 |
ENSMUST00000051395.9
|
proline rich 11 |
|
| chr8_+_57964921 Show fit | 49.86 |
ENSMUST00000067925.8
|
high mobility group box 2 |
|
| chr14_+_46997984 Show fit | 48.09 |
ENSMUST00000067426.6
|
cyclin-dependent kinase inhibitor 3 |
|
| chr17_+_25235310 Show fit | 47.21 |
ENSMUST00000024983.12
|
intraflagellar transport 140 |
|
| chr7_-_120581535 Show fit | 46.68 |
ENSMUST00000033169.9
|
cerebellar degeneration-related 2 |
|
| chr6_+_124807176 Show fit | 42.26 |
ENSMUST00000131847.8
ENSMUST00000151674.3 |
cell division cycle associated 3 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 126.5 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.6 | 113.8 | GO:0044843 | cell cycle G1/S phase transition(GO:0044843) |
| 6.7 | 100.3 | GO:0035721 | intraciliary retrograde transport(GO:0035721) |
| 9.3 | 93.4 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 9.3 | 93.0 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 8.5 | 93.0 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.2 | 79.6 | GO:0051301 | cell division(GO:0051301) |
| 4.1 | 78.2 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.6 | 73.3 | GO:0000910 | cytokinesis(GO:0000910) |
| 3.7 | 73.1 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 226.4 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 1.4 | 166.1 | GO:0000776 | kinetochore(GO:0000776) |
| 1.2 | 154.0 | GO:0005814 | centriole(GO:0005814) |
| 0.7 | 126.9 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 3.3 | 125.2 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 3.7 | 116.9 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 1.5 | 94.4 | GO:0005871 | kinesin complex(GO:0005871) |
| 18.7 | 93.4 | GO:0000799 | nuclear condensin complex(GO:0000799) |
| 15.1 | 90.6 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 8.7 | 86.7 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 236.7 | GO:0042393 | histone binding(GO:0042393) |
| 1.5 | 170.8 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.2 | 129.4 | GO:0003682 | chromatin binding(GO:0003682) |
| 4.4 | 88.5 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 8.8 | 88.2 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.4 | 88.0 | GO:0008017 | microtubule binding(GO:0008017) |
| 2.6 | 84.5 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.5 | 76.6 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 4.2 | 76.2 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 18.6 | 74.2 | GO:0031720 | haptoglobin binding(GO:0031720) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.0 | 348.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 4.3 | 199.7 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 3.0 | 171.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.4 | 115.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 2.3 | 100.0 | PID ATR PATHWAY | ATR signaling pathway |
| 4.4 | 82.8 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.5 | 80.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.9 | 63.9 | PID E2F PATHWAY | E2F transcription factor network |
| 1.6 | 53.8 | PID AURORA A PATHWAY | Aurora A signaling |
| 1.1 | 53.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 208.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 7.8 | 156.5 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 4.8 | 138.0 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 7.5 | 120.2 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 8.7 | 112.8 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 3.5 | 112.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 2.3 | 107.6 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 5.8 | 86.8 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.9 | 86.1 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 3.9 | 85.0 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |