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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Tfap4
Z-value: 1.59
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Transcription factors associated with Tfap4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tfap4 | mm39_v1_chr16_-_4377640_4377718 | -0.64 | 3.0e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tfap4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 17.1 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 0.3 | 13.3 | GO:0010866 | regulation of triglyceride biosynthetic process(GO:0010866) |
| 0.1 | 8.4 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.1 | 7.5 | GO:0000045 | autophagosome assembly(GO:0000045) |
| 0.3 | 5.4 | GO:0045542 | positive regulation of cholesterol biosynthetic process(GO:0045542) positive regulation of cholesterol metabolic process(GO:0090205) |
| 0.9 | 5.3 | GO:0015889 | cobalamin transport(GO:0015889) |
| 0.4 | 5.1 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.1 | 5.1 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
| 0.2 | 4.7 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
| 0.0 | 4.4 | GO:0016236 | macroautophagy(GO:0016236) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 17.1 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.0 | 9.9 | GO:0000323 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.1 | 8.9 | GO:0005776 | autophagosome(GO:0005776) |
| 1.2 | 7.2 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
| 0.0 | 6.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 5.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.3 | 3.3 | GO:1990812 | growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812) |
| 0.1 | 3.0 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.2 | 2.9 | GO:0020005 | symbiont-containing vacuole membrane(GO:0020005) |
| 0.0 | 2.9 | GO:0005769 | early endosome(GO:0005769) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 9.5 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.6 | 8.4 | GO:0016151 | nickel cation binding(GO:0016151) |
| 0.0 | 7.3 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.0 | 6.9 | GO:0008134 | transcription factor binding(GO:0008134) |
| 0.3 | 6.5 | GO:0005537 | mannose binding(GO:0005537) |
| 0.5 | 5.3 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.1 | 5.3 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.0 | 5.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 4.4 | GO:0050681 | androgen receptor binding(GO:0050681) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 4.1 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 3.2 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.1 | 2.6 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 2.1 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 1.7 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.6 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 1.3 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 1.1 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 1.1 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.0 | 4.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 3.3 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 2.6 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.3 | 2.4 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.2 | 2.1 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 2.1 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 1.8 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.0 | 1.8 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 1.7 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |