Project
avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Tal1
Z-value: 7.19
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Transcription factors associated with Tal1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tal1 | mm39_v1_chr4_+_114916703_114916759 | 0.97 | 9.3e-23 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tal1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.5 | 172.8 | GO:0034242 | negative regulation of syncytium formation by plasma membrane fusion(GO:0034242) |
| 31.7 | 126.8 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 2.4 | 94.2 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 4.7 | 89.6 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 17.4 | 86.8 | GO:0045347 | negative regulation of MHC class II biosynthetic process(GO:0045347) |
| 9.0 | 81.3 | GO:0015671 | oxygen transport(GO:0015671) |
| 2.7 | 66.3 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 1.7 | 65.2 | GO:0006779 | porphyrin-containing compound biosynthetic process(GO:0006779) |
| 5.0 | 59.6 | GO:0001955 | blood vessel maturation(GO:0001955) |
| 0.8 | 59.0 | GO:0042982 | amyloid precursor protein metabolic process(GO:0042982) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 174.4 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 159.6 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.2 | 111.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 6.3 | 94.2 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 10.2 | 81.3 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.1 | 81.1 | GO:0031410 | cytoplasmic vesicle(GO:0031410) |
| 5.7 | 80.2 | GO:0020005 | symbiont-containing vacuole membrane(GO:0020005) |
| 0.1 | 52.7 | GO:0005768 | endosome(GO:0005768) |
| 1.9 | 40.2 | GO:0031143 | pseudopodium(GO:0031143) |
| 6.1 | 36.5 | GO:0032437 | cuticular plate(GO:0032437) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 172.8 | GO:0050699 | WW domain binding(GO:0050699) |
| 4.6 | 141.2 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 1.0 | 130.8 | GO:0004540 | ribonuclease activity(GO:0004540) |
| 1.1 | 89.3 | GO:0030507 | spectrin binding(GO:0030507) |
| 2.7 | 87.3 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) |
| 14.5 | 86.8 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.1 | 56.3 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.1 | 48.7 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 3.8 | 45.6 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 6.4 | 44.8 | GO:0005344 | oxygen transporter activity(GO:0005344) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 114.2 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.3 | 92.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 59.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 1.1 | 40.2 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.4 | 37.9 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 1.2 | 31.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.5 | 29.0 | PID EPO PATHWAY | EPO signaling pathway |
| 0.5 | 26.0 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 1.3 | 22.4 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.5 | 22.1 | PID RAS PATHWAY | Regulation of Ras family activation |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 159.8 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 5.1 | 86.8 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 2.0 | 76.5 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 1.2 | 63.2 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.1 | 62.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 2.5 | 40.5 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.6 | 35.3 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.9 | 34.5 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.6 | 32.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.8 | 32.0 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |