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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Pparg_Rxrg
Z-value: 7.79
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Transcription factors associated with Pparg_Rxrg
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rxrg | mm39_v1_chr1_+_167445815_167445878 | 0.92 | 1.1e-15 | Click! |
| Pparg | mm39_v1_chr6_+_115398996_115399030 | 0.47 | 3.8e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Pparg_Rxrg
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_46120327 Show fit | 110.55 |
ENSMUST00000043739.6
ENSMUST00000237098.2 |
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 |
|
| chr19_+_39275518 Show fit | 109.62 |
ENSMUST00000003137.15
|
cytochrome P450, family 2, subfamily c, polypeptide 29 |
|
| chr17_-_46749370 Show fit | 86.39 |
ENSMUST00000087012.7
|
solute carrier family 22 (organic anion transporter), member 7 |
|
| chr9_-_46146558 Show fit | 81.67 |
ENSMUST00000121916.8
ENSMUST00000034586.9 |
apolipoprotein C-III |
|
| chr7_+_26821266 Show fit | 71.67 |
ENSMUST00000206552.2
|
cytochrome P450, family 2, subfamily f, polypeptide 2 |
|
| chr9_-_46146928 Show fit | 71.48 |
ENSMUST00000118649.8
|
apolipoprotein C-III |
|
| chr15_+_82336535 Show fit | 65.71 |
ENSMUST00000089129.7
ENSMUST00000229313.2 ENSMUST00000231136.2 |
cytochrome P450, family 2, subfamily d, polypeptide 9 |
|
| chr15_-_82648376 Show fit | 56.91 |
ENSMUST00000055721.6
|
cytochrome P450, family 2, subfamily d, polypeptide 40 |
|
| chr3_+_138121245 Show fit | 46.20 |
ENSMUST00000161312.8
ENSMUST00000013458.9 |
alcohol dehydrogenase 4 (class II), pi polypeptide |
|
| chr9_-_15212849 Show fit | 43.10 |
ENSMUST00000034414.10
|
RIKEN cDNA 4931406C07 gene |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.2 | 191.0 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 4.3 | 184.3 | GO:0019369 | arachidonic acid metabolic process(GO:0019369) |
| 5.4 | 168.3 | GO:0080184 | response to phenylpropanoid(GO:0080184) |
| 38.3 | 153.1 | GO:0010982 | regulation of high-density lipoprotein particle clearance(GO:0010982) |
| 9.3 | 111.0 | GO:0034625 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 4.1 | 98.5 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 23.9 | 71.7 | GO:0090420 | naphthalene metabolic process(GO:0018931) naphthalene-containing compound metabolic process(GO:0090420) |
| 6.6 | 66.3 | GO:0030300 | regulation of intestinal cholesterol absorption(GO:0030300) |
| 13.1 | 65.6 | GO:0071718 | sodium-independent icosanoid transport(GO:0071718) |
| 5.9 | 52.8 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 369.1 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.9 | 173.9 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 14.3 | 157.7 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.7 | 151.5 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.2 | 94.7 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 81.3 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.7 | 60.4 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 2.0 | 59.1 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.2 | 48.6 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 11.8 | 47.4 | GO:0017133 | mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.4 | 252.5 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 5.8 | 244.2 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 39.9 | 159.4 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 3.2 | 131.9 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 9.3 | 111.0 | GO:0102337 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 18.5 | 110.8 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 2.6 | 55.5 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 9.0 | 53.8 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 2.9 | 52.2 | GO:0008430 | selenium binding(GO:0008430) |
| 9.5 | 47.4 | GO:0004021 | L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 73.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.6 | 50.4 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.8 | 44.2 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.6 | 42.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 31.9 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.6 | 16.8 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 13.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 13.2 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.5 | 10.4 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.2 | 9.6 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.4 | 148.0 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 9.0 | 125.8 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 3.5 | 114.6 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.6 | 87.0 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 5.3 | 84.4 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.7 | 71.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 5.5 | 66.2 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.8 | 61.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.7 | 56.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 4.2 | 46.2 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |