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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Hnf4a
Z-value: 10.60
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Transcription factors associated with Hnf4a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hnf4a | mm39_v1_chr2_+_163389068_163389108 | 0.61 | 7.7e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hnf4a
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_39275518 Show fit | 160.92 |
ENSMUST00000003137.15
|
cytochrome P450, family 2, subfamily c, polypeptide 29 |
|
| chr4_-_62005498 Show fit | 128.85 |
ENSMUST00000107488.4
ENSMUST00000107472.8 ENSMUST00000084531.11 |
major urinary protein 3 |
|
| chr17_-_46749370 Show fit | 103.46 |
ENSMUST00000087012.7
|
solute carrier family 22 (organic anion transporter), member 7 |
|
| chr10_-_128796834 Show fit | 99.95 |
ENSMUST00000026398.5
|
methyltransferase like 7B |
|
| chr15_-_82648376 Show fit | 97.82 |
ENSMUST00000055721.6
|
cytochrome P450, family 2, subfamily d, polypeptide 40 |
|
| chr19_-_40062174 Show fit | 93.25 |
ENSMUST00000048959.5
|
cytochrome P450, family 2, subfamily c, polypeptide 54 |
|
| chr2_+_172994841 Show fit | 80.60 |
ENSMUST00000029017.6
|
phosphoenolpyruvate carboxykinase 1, cytosolic |
|
| chr2_-_25390625 Show fit | 74.10 |
ENSMUST00000040042.11
|
complement component 8, gamma polypeptide |
|
| chr3_+_122688721 Show fit | 69.88 |
ENSMUST00000023820.6
|
fatty acid binding protein 2, intestinal |
|
| chr4_-_60697274 Show fit | 69.46 |
ENSMUST00000117932.2
|
major urinary protein 12 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.2 | 469.5 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 9.5 | 274.2 | GO:0035634 | response to stilbenoid(GO:0035634) |
| 5.2 | 222.5 | GO:0019369 | arachidonic acid metabolic process(GO:0019369) |
| 28.5 | 142.7 | GO:0071718 | sodium-independent icosanoid transport(GO:0071718) |
| 8.2 | 139.4 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 6.8 | 102.2 | GO:0015747 | urate transport(GO:0015747) |
| 32.8 | 98.4 | GO:1903699 | tarsal gland development(GO:1903699) |
| 0.5 | 97.6 | GO:0009636 | response to toxic substance(GO:0009636) |
| 2.3 | 94.5 | GO:0050892 | intestinal absorption(GO:0050892) |
| 22.3 | 89.2 | GO:0015910 | peroxisomal long-chain fatty acid import(GO:0015910) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 634.9 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 282.6 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.9 | 157.4 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 1.5 | 139.6 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 135.5 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 3.8 | 111.5 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.4 | 103.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 3.9 | 90.8 | GO:0042627 | chylomicron(GO:0042627) |
| 8.2 | 89.7 | GO:0045179 | apical cortex(GO:0045179) |
| 0.5 | 89.7 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.3 | 390.3 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 4.5 | 199.0 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 32.2 | 193.0 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 7.0 | 188.2 | GO:0070330 | aromatase activity(GO:0070330) |
| 19.9 | 178.9 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.7 | 151.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 36.7 | 146.8 | GO:0071614 | linoleic acid epoxygenase activity(GO:0071614) |
| 33.3 | 133.1 | GO:0047961 | glycine N-acyltransferase activity(GO:0047961) |
| 1.5 | 128.8 | GO:0005550 | pheromone binding(GO:0005550) |
| 16.4 | 98.4 | GO:0032896 | palmitoyl-CoA 9-desaturase activity(GO:0032896) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 79.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.8 | 65.3 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.3 | 39.4 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 1.0 | 35.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 24.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.7 | 16.1 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.2 | 15.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 12.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 12.5 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 6.7 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 182.5 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 12.4 | 173.0 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 8.2 | 163.8 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 11.0 | 142.7 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 6.0 | 84.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 6.2 | 80.6 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 4.4 | 74.1 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 5.2 | 67.0 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.6 | 66.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 1.9 | 54.6 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |