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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Cebpb
Z-value: 3.45
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Transcription factors associated with Cebpb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Cebpb | mm39_v1_chr2_+_167530835_167530894 | -0.07 | 7.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Cebpb
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_109678685 Show fit | 28.41 |
ENSMUST00000112022.5
|
cathelicidin antimicrobial peptide |
|
| chr7_+_13467422 Show fit | 26.09 |
ENSMUST00000086148.8
|
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2 |
|
| chr9_+_110248815 Show fit | 23.01 |
ENSMUST00000035061.9
|
neutrophilic granule protein |
|
| chrX_-_161747552 Show fit | 19.67 |
ENSMUST00000038769.3
|
S100 calcium binding protein G |
|
| chr10_+_23727325 Show fit | 18.30 |
ENSMUST00000020190.8
|
vanin 3 |
|
| chr2_-_32277773 Show fit | 15.94 |
ENSMUST00000050785.14
|
lipocalin 2 |
|
| chr2_-_32278245 Show fit | 15.71 |
ENSMUST00000192241.2
|
lipocalin 2 |
|
| chr11_-_99383938 Show fit | 14.85 |
ENSMUST00000006969.8
|
keratin 23 |
|
| chr8_-_46664321 Show fit | 14.55 |
ENSMUST00000034049.5
|
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 |
|
| chr10_+_79722081 Show fit | 13.96 |
ENSMUST00000046091.7
|
elastase, neutrophil expressed |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.5 | 31.6 | GO:0015891 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 2.6 | 28.4 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.4 | 25.8 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
| 3.9 | 23.2 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 5.8 | 23.0 | GO:1901491 | negative regulation of lymphangiogenesis(GO:1901491) |
| 6.3 | 18.9 | GO:0033189 | response to vitamin A(GO:0033189) |
| 0.4 | 18.3 | GO:0006767 | water-soluble vitamin metabolic process(GO:0006767) |
| 0.6 | 17.8 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 5.5 | 16.4 | GO:0009087 | methionine catabolic process(GO:0009087) |
| 0.4 | 15.1 | GO:0006825 | copper ion transport(GO:0006825) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 1.3 | 28.4 | GO:0042581 | specific granule(GO:0042581) |
| 0.4 | 23.2 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 17.6 | GO:0031410 | cytoplasmic vesicle(GO:0031410) |
| 0.1 | 17.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 15.8 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 14.4 | GO:0005741 | mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968) |
| 1.8 | 14.3 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 13.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 2.0 | 11.9 | GO:0044279 | other organism cell membrane(GO:0044218) other organism membrane(GO:0044279) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 40.9 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 3.6 | 25.1 | GO:0050656 | alcohol sulfotransferase activity(GO:0004027) 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656) |
| 4.6 | 23.2 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.4 | 22.5 | GO:0008146 | sulfotransferase activity(GO:0008146) |
| 0.1 | 21.8 | GO:0002020 | protease binding(GO:0002020) |
| 2.5 | 19.7 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.2 | 18.8 | GO:0042562 | hormone binding(GO:0042562) |
| 0.2 | 18.6 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 1.5 | 16.9 | GO:0015217 | ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217) |
| 4.1 | 16.4 | GO:0004478 | methionine adenosyltransferase activity(GO:0004478) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 3.2 | 28.4 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.5 | 17.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 17.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 17.1 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.3 | 14.3 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.3 | 12.8 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 12.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 9.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 7.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 43.2 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.3 | 23.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.7 | 20.5 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.7 | 18.7 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.8 | 16.5 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.5 | 16.4 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.3 | 14.5 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.2 | 11.8 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.9 | 10.2 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.5 | 7.5 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |