ISMARA results: Zbtb18

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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Zbtb18

Z-value: 2.32

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Transcription factors associated with Zbtb18

Gene Symbol	Gene ID	Gene Info
Zbtb18 Ensembl NCBI MGI UniProt	ENSMUSG00000063659.6	zinc finger and BTB domain containing 18

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Zbtb18	mm10_v2_chr1_+_177445660_177445821	-0.24	1.5e-01	Click!

Activity profile of Zbtb18 motif

Sorted Z-values of Zbtb18 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_-_111691002 Show fit	19.74	ENSMUST00000034435.5	Ctrb1 Ensembl NCBI MGI UniProt Show fit	chymotrypsinogen B1
chr4_-_141825997 Show fit	17.63	ENSMUST00000102481.3	Cela2a Ensembl NCBI MGI UniProt Show fit	chymotrypsin-like elastase family, member 2A
chr8_-_105933832 Show fit	13.18	ENSMUST00000034368.6	Ctrl Ensembl NCBI MGI UniProt Show fit	chymotrypsin-like
chr17_-_12675833 Show fit	10.32	ENSMUST00000024596.8	Slc22a1 Ensembl NCBI MGI UniProt Show fit	solute carrier family 22 (organic cation transporter), member 1
chr4_-_115496129 Show fit	9.92	ENSMUST00000030487.2	Cyp4a14 Ensembl NCBI MGI UniProt Show fit	cytochrome P450, family 4, subfamily a, polypeptide 14
chr2_-_28563362 Show fit	9.89	ENSMUST00000028161.5	Cel Ensembl NCBI MGI UniProt Show fit	carboxyl ester lipase
chr1_-_150466165 Show fit	9.82	ENSMUST00000162367.1 ENSMUST00000161611.1 ENSMUST00000161320.1 ENSMUST00000159035.1	Prg4 Ensembl NCBI MGI UniProt Show fit	proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
chr6_-_41035501 Show fit	9.37	ENSMUST00000031931.5	2210010C04Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 2210010C04 gene
chr8_-_24576297 Show fit	8.98	ENSMUST00000033953.7 ENSMUST00000121992.1	Ido2 Ensembl NCBI MGI UniProt Show fit	indoleamine 2,3-dioxygenase 2
chr14_+_30886521 Show fit	8.96	ENSMUST00000168782.1	Itih4 Ensembl NCBI MGI UniProt Show fit	inter alpha-trypsin inhibitor, heavy chain 4

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb18

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	20.6	GO:0007586	digestion(GO:0007586)
0.8	18.9	GO:0061436	establishment of skin barrier(GO:0061436)
4.5	17.9	GO:0071718	sodium-independent icosanoid transport(GO:0071718)
5.1	15.4	GO:0030573	bile acid catabolic process(GO:0030573)
0.4	15.3	GO:0030212	hyaluronan metabolic process(GO:0030212)
4.2	12.7	GO:0019442	tryptophan catabolic process to acetyl-CoA(GO:0019442)
2.6	10.3	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
1.2	9.9	GO:0016127	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
1.2	9.8	GO:0045409	negative regulation of interleukin-6 biosynthetic process(GO:0045409)
1.1	9.0	GO:0006569	tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218) kynurenine metabolic process(GO:0070189)

Showing 1 to 10 of 227 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	91.8	GO:0005615	extracellular space(GO:0005615)
0.0	25.9	GO:0005783	endoplasmic reticulum(GO:0005783)
0.0	22.5	GO:0005764	lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.2	21.2	GO:0009925	basal plasma membrane(GO:0009925)
0.3	10.1	GO:0042588	zymogen granule(GO:0042588)
2.9	8.6	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.2	8.4	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.0	8.3	GO:0016323	basolateral plasma membrane(GO:0016323)
0.1	7.4	GO:0005581	collagen trimer(GO:0005581)
1.4	7.0	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)

Showing 1 to 10 of 77 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	60.9	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.9	17.9	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.7	17.1	GO:0005540	hyaluronic acid binding(GO:0005540)
5.1	15.4	GO:0047787	delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
0.1	14.0	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
3.2	12.7	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1	11.8	GO:0005518	collagen binding(GO:0005518)
0.4	11.4	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.3	10.4	GO:0008236	serine-type peptidase activity(GO:0008236)
3.4	10.3	GO:0005333	norepinephrine transmembrane transporter activity(GO:0005333)

Showing 1 to 10 of 163 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	48.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	17.0	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	9.8	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	7.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	4.9	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	4.2	PID IL23 PATHWAY	IL23-mediated signaling events
0.1	4.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.1	4.0	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	3.9	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.1	3.9	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly

Showing 1 to 10 of 41 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	21.7	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.7	20.8	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
1.6	17.9	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
1.2	15.4	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.8	10.3	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.4	8.6	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.2	7.3	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.2	6.7	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.4	6.2	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.2	5.9	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport

Showing 1 to 10 of 60 entries

Results for Zbtb18

Z-value: 2.32

Motif logo

Transcription factors associated with Zbtb18

Activity-expression correlation:

Activity profile of Zbtb18 motif

Sorted Z-values of Zbtb18 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb18

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: