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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Tbx4

Z-value: 1.15

Motif logo

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Transcription factors associated with Tbx4

Gene Symbol Gene ID Gene Info
Tbx4
ENSMUSG00000000094.6 T-box 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbx4mm10_v2_chr11_+_85886360_85886422-0.382.1e-02Click!

Activity profile of Tbx4 motif

Sorted Z-values of Tbx4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_20601958 9.20 ENSMUST00000087638.3
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr19_+_37697792 7.31 ENSMUST00000025946.5
Cyp26a1
cytochrome P450, family 26, subfamily a, polypeptide 1
chr10_+_87861309 5.37 ENSMUST00000122100.1
Igf1
insulin-like growth factor 1
chr2_-_148045891 3.86 ENSMUST00000109964.1
Foxa2
forkhead box A2
chr7_-_100658394 3.80 ENSMUST00000138830.1
ENSMUST00000107044.3
ENSMUST00000116287.2
Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chr7_-_100658364 3.68 ENSMUST00000107043.1
Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chr19_-_42202150 3.17 ENSMUST00000018966.7
Sfrp5
secreted frizzled-related sequence protein 5
chr2_+_164562579 2.94 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
Wfdc2
WAP four-disulfide core domain 2
chr4_+_43641262 2.83 ENSMUST00000123351.1
ENSMUST00000128549.1
Npr2
natriuretic peptide receptor 2
chr16_-_23988852 2.61 ENSMUST00000023151.5
Bcl6
B cell leukemia/lymphoma 6
chrX_+_101383726 2.48 ENSMUST00000119190.1
Gjb1
gap junction protein, beta 1
chr7_+_79810727 2.39 ENSMUST00000107394.1
Mesp2
mesoderm posterior 2
chr1_-_105356658 2.32 ENSMUST00000058688.5
ENSMUST00000172299.1
Rnf152
ring finger protein 152
chr15_+_57694651 2.28 ENSMUST00000096430.4
Zhx2
zinc fingers and homeoboxes 2
chr4_+_125490688 2.14 ENSMUST00000030676.7
Grik3
glutamate receptor, ionotropic, kainate 3
chr10_-_86705485 2.12 ENSMUST00000020238.7
Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chr9_-_43239816 2.08 ENSMUST00000034512.5
Oaf
OAF homolog (Drosophila)
chr11_+_23306884 2.05 ENSMUST00000180046.1
Usp34
ubiquitin specific peptidase 34
chr2_-_148046896 2.04 ENSMUST00000172928.1
ENSMUST00000047315.3
Foxa2
forkhead box A2
chr10_-_24101951 1.89 ENSMUST00000170267.1
Taar8c
trace amine-associated receptor 8C
chr4_+_53440516 1.64 ENSMUST00000107651.2
ENSMUST00000107647.1
Slc44a1
solute carrier family 44, member 1
chr9_+_103008479 1.59 ENSMUST00000035148.6
Slco2a1
solute carrier organic anion transporter family, member 2a1
chr2_+_32609043 1.44 ENSMUST00000128811.1
St6galnac6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr7_-_28302238 1.36 ENSMUST00000108315.3
Dll3
delta-like 3 (Drosophila)
chr14_-_30943275 1.35 ENSMUST00000006704.8
ENSMUST00000163118.1
Itih1
inter-alpha trypsin inhibitor, heavy chain 1
chr19_-_28963863 1.32 ENSMUST00000161813.1
4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr3_+_75557530 1.25 ENSMUST00000161776.1
ENSMUST00000029423.8
Serpini1
serine (or cysteine) peptidase inhibitor, clade I, member 1
chr9_+_108296853 1.19 ENSMUST00000035230.5
Amt
aminomethyltransferase
chrX_+_42502533 1.18 ENSMUST00000005839.4
Sh2d1a
SH2 domain protein 1A
chr10_+_86705811 1.17 ENSMUST00000061458.7
ENSMUST00000075632.6
BC030307
cDNA sequence BC030307
chr11_-_98149551 1.16 ENSMUST00000103143.3
Fbxl20
F-box and leucine-rich repeat protein 20
chr1_-_138847579 1.15 ENSMUST00000093486.3
ENSMUST00000046870.6
Lhx9
LIM homeobox protein 9
chr11_-_116654245 1.14 ENSMUST00000021166.5
Cygb
cytoglobin
chr13_+_38151343 1.14 ENSMUST00000124830.1
Dsp
desmoplakin
chr12_+_84642896 1.09 ENSMUST00000095551.4
Vrtn
vertebrae development associated
chr11_+_78178105 1.09 ENSMUST00000147819.1
Tlcd1
TLC domain containing 1
chr11_+_23306910 1.09 ENSMUST00000137823.1
Usp34
ubiquitin specific peptidase 34
chr13_+_38151324 1.06 ENSMUST00000127906.1
Dsp
desmoplakin
chr11_-_99620432 1.06 ENSMUST00000073853.2
Gm11562
predicted gene 11562
chrX_+_169036610 1.05 ENSMUST00000087016.4
ENSMUST00000112129.1
ENSMUST00000112131.2
Arhgap6
Rho GTPase activating protein 6
chr15_-_10470490 1.05 ENSMUST00000136591.1
Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr7_-_108930151 1.04 ENSMUST00000055745.3
Nlrp10
NLR family, pyrin domain containing 10
chr6_+_83054653 1.03 ENSMUST00000092618.6
Aup1
ancient ubiquitous protein 1
chr10_-_120899067 1.02 ENSMUST00000092143.5
Msrb3
methionine sulfoxide reductase B3
chrM_+_9452 1.02 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr3_-_75556759 1.00 ENSMUST00000162138.1
ENSMUST00000029424.5
ENSMUST00000161137.1
Pdcd10
programmed cell death 10
chr11_+_95414078 0.99 ENSMUST00000107724.2
ENSMUST00000150884.1
ENSMUST00000107722.1
ENSMUST00000127713.1
Spop
speckle-type POZ protein
chr4_-_63861326 0.99 ENSMUST00000030047.2
Tnfsf8
tumor necrosis factor (ligand) superfamily, member 8
chr5_+_120513102 0.98 ENSMUST00000111889.1
Slc8b1
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr4_-_19922599 0.93 ENSMUST00000029900.5
Atp6v0d2
ATPase, H+ transporting, lysosomal V0 subunit D2
chr15_-_81360739 0.93 ENSMUST00000023040.7
Slc25a17
solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17
chr13_-_113180897 0.89 ENSMUST00000038212.7
Gzmk
granzyme K
chr13_+_96542602 0.88 ENSMUST00000179226.1
Col4a3bp
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
chr11_-_84068766 0.88 ENSMUST00000018792.5
Dusp14
dual specificity phosphatase 14
chr7_+_46796088 0.88 ENSMUST00000006774.4
ENSMUST00000165031.1
Gtf2h1
general transcription factor II H, polypeptide 1
chr4_-_42168603 0.86 ENSMUST00000098121.3
Gm13305
predicted gene 13305
chr2_+_103424120 0.84 ENSMUST00000171693.1
Elf5
E74-like factor 5
chr13_+_96542727 0.84 ENSMUST00000077672.4
ENSMUST00000109444.2
Col4a3bp
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
chr11_-_22286795 0.81 ENSMUST00000109563.2
ENSMUST00000180360.1
Ehbp1
EH domain binding protein 1
chr6_+_42286676 0.81 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr3_-_121263314 0.80 ENSMUST00000029777.7
Tmem56
transmembrane protein 56
chr6_+_42286709 0.77 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr15_+_10952332 0.75 ENSMUST00000022853.8
ENSMUST00000110523.1
C1qtnf3
C1q and tumor necrosis factor related protein 3
chr16_+_62814676 0.75 ENSMUST00000055557.5
Stx19
syntaxin 19
chr3_-_121263159 0.73 ENSMUST00000128909.1
Tmem56
transmembrane protein 56
chr15_+_38219203 0.73 ENSMUST00000081966.4
Odf1
outer dense fiber of sperm tails 1
chr17_-_78937031 0.72 ENSMUST00000024885.8
Cebpz
CCAAT/enhancer binding protein zeta
chrM_+_10167 0.72 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chrM_+_9870 0.72 ENSMUST00000084013.1
mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr4_+_53440388 0.71 ENSMUST00000102911.3
ENSMUST00000107646.2
Slc44a1
solute carrier family 44, member 1
chr10_+_96136603 0.70 ENSMUST00000074615.6
Gm5426
predicted pseudogene 5426
chr2_+_54436317 0.69 ENSMUST00000112636.1
ENSMUST00000112635.1
ENSMUST00000112634.1
Galnt13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13
chr6_-_126166726 0.69 ENSMUST00000112244.2
ENSMUST00000050484.7
Ntf3
neurotrophin 3
chr6_-_94700137 0.69 ENSMUST00000101126.2
ENSMUST00000032105.4
Lrig1
leucine-rich repeats and immunoglobulin-like domains 1
chr16_-_84835484 0.68 ENSMUST00000114191.1
Atp5j
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr2_+_103424056 0.68 ENSMUST00000028609.7
Elf5
E74-like factor 5
chr4_+_42950369 0.67 ENSMUST00000084662.5
Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr2_+_10047838 0.67 ENSMUST00000181588.1
C630004M23Rik
RIKEN cDNA C630004M23 gene
chr13_-_111490028 0.66 ENSMUST00000091236.4
Gpbp1
GC-rich promoter binding protein 1
chr13_+_113209659 0.65 ENSMUST00000038144.8
Esm1
endothelial cell-specific molecule 1
chr14_+_51893610 0.64 ENSMUST00000047726.5
ENSMUST00000161888.1
Slc39a2
solute carrier family 39 (zinc transporter), member 2
chr12_-_31634592 0.63 ENSMUST00000020979.7
ENSMUST00000177962.1
Bcap29
B cell receptor associated protein 29
chr6_+_15196949 0.62 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
Foxp2
forkhead box P2
chr11_-_97575210 0.60 ENSMUST00000107596.2
Srcin1
SRC kinase signaling inhibitor 1
chr18_+_5591860 0.60 ENSMUST00000025081.5
ENSMUST00000159390.1
Zeb1
zinc finger E-box binding homeobox 1
chr9_+_32116040 0.59 ENSMUST00000174641.1
Arhgap32
Rho GTPase activating protein 32
chr7_-_120095177 0.59 ENSMUST00000046993.3
Dnah3
dynein, axonemal, heavy chain 3
chr2_+_54436432 0.59 ENSMUST00000136642.1
Galnt13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13
chr9_-_48495321 0.59 ENSMUST00000170000.2
Rbm7
RNA binding motif protein 7
chr1_+_6730135 0.59 ENSMUST00000155921.1
St18
suppression of tumorigenicity 18
chr13_-_96542479 0.57 ENSMUST00000022172.4
Polk
polymerase (DNA directed), kappa
chr11_-_86544754 0.57 ENSMUST00000138810.1
ENSMUST00000058286.2
ENSMUST00000154617.1
Rps6kb1
ribosomal protein S6 kinase, polypeptide 1
chr11_-_23770953 0.56 ENSMUST00000102864.3
Rel
reticuloendotheliosis oncogene
chr12_-_56345862 0.56 ENSMUST00000021416.7
Mbip
MAP3K12 binding inhibitory protein 1
chr10_+_97693053 0.55 ENSMUST00000060703.4
Ccer1
coiled coil glutamate rich protein 1
chr4_+_148000722 0.55 ENSMUST00000103230.4
Nppa
natriuretic peptide type A
chr1_+_40580227 0.55 ENSMUST00000027233.7
Slc9a4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr11_-_84068357 0.54 ENSMUST00000100705.4
Dusp14
dual specificity phosphatase 14
chr2_-_70662108 0.54 ENSMUST00000180559.1
Gm26558
predicted gene, 26558
chr18_-_46212595 0.54 ENSMUST00000037011.4
Trim36
tripartite motif-containing 36
chrX_+_133908418 0.53 ENSMUST00000033606.8
ENSMUST00000113303.1
ENSMUST00000165805.1
Srpx2
sushi-repeat-containing protein, X-linked 2
chr13_+_93304066 0.52 ENSMUST00000109493.1
Homer1
homer homolog 1 (Drosophila)
chr1_+_6730051 0.52 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
St18
suppression of tumorigenicity 18
chr14_-_70642268 0.50 ENSMUST00000022697.5
Fgf17
fibroblast growth factor 17
chr13_+_80886095 0.50 ENSMUST00000161441.1
Arrdc3
arrestin domain containing 3
chr1_-_24612700 0.49 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chr11_-_20741447 0.49 ENSMUST00000177543.1
Aftph
aftiphilin
chr16_-_9994921 0.48 ENSMUST00000115835.1
Grin2a
glutamate receptor, ionotropic, NMDA2A (epsilon 1)
chr5_+_31094984 0.47 ENSMUST00000066505.1
Gm9924
predicted gene 9924
chr13_-_108158584 0.47 ENSMUST00000163558.1
Ndufaf2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2
chr3_-_30140407 0.47 ENSMUST00000108271.3
Mecom
MDS1 and EVI1 complex locus
chr7_-_99858872 0.45 ENSMUST00000036274.6
Spcs2
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr9_+_32372409 0.45 ENSMUST00000047334.8
Kcnj1
potassium inwardly-rectifying channel, subfamily J, member 1
chr18_-_60591783 0.44 ENSMUST00000056533.7
Myoz3
myozenin 3
chr6_-_140041409 0.44 ENSMUST00000032356.6
Plcz1
phospholipase C, zeta 1
chr14_-_55524938 0.44 ENSMUST00000178694.1
Nrl
neural retina leucine zipper gene
chrX_+_42502596 0.41 ENSMUST00000115070.1
ENSMUST00000153948.1
Sh2d1a
SH2 domain protein 1A
chrX_-_162829379 0.39 ENSMUST00000041370.4
ENSMUST00000112316.2
ENSMUST00000112315.1
Txlng
taxilin gamma
chr14_-_55524975 0.36 ENSMUST00000062232.7
Nrl
neural retina leucine zipper gene
chr19_+_8617991 0.35 ENSMUST00000010250.2
Slc22a6
solute carrier family 22 (organic anion transporter), member 6
chr7_-_79793788 0.32 ENSMUST00000032760.5
Mesp1
mesoderm posterior 1
chr16_-_50330987 0.31 ENSMUST00000114488.1
Bbx
bobby sox homolog (Drosophila)
chr14_+_53776930 0.30 ENSMUST00000103670.2
Trav3-4
T cell receptor alpha variable 3-4
chr19_-_45235811 0.30 ENSMUST00000099401.4
Lbx1
ladybird homeobox homolog 1 (Drosophila)
chr7_+_46240956 0.29 ENSMUST00000164538.1
Otog
otogelin
chr2_+_52857844 0.29 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
Fmnl2
formin-like 2
chr4_+_114680769 0.29 ENSMUST00000146346.1
Gm12829
predicted gene 12829
chr14_+_15437623 0.29 ENSMUST00000181388.1
B230110C06Rik
RIKEN cDNA B230110C06 gene
chr1_+_132316112 0.28 ENSMUST00000082125.5
ENSMUST00000072177.7
Nuak2
NUAK family, SNF1-like kinase, 2
chr9_+_44326804 0.27 ENSMUST00000054708.3
Dpagt1
dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr14_-_51988829 0.26 ENSMUST00000181008.1
Gm16617
predicted gene, 16617
chr3_-_94582716 0.25 ENSMUST00000029783.9
Snx27
sorting nexin family member 27
chr17_+_35567450 0.24 ENSMUST00000044326.4
2300002M23Rik
RIKEN cDNA 2300002M23 gene
chr14_+_45351473 0.24 ENSMUST00000111835.2
Styx
serine/threonine/tyrosine interaction protein
chr16_+_19028232 0.24 ENSMUST00000074116.4
Gm10088
predicted gene 10088
chr9_-_69760924 0.21 ENSMUST00000071281.4
Foxb1
forkhead box B1
chr2_-_30178422 0.20 ENSMUST00000100220.4
ENSMUST00000179795.1
D2Wsu81e
DNA segment, Chr 2, Wayne State University 81, expressed
chr6_+_7555053 0.19 ENSMUST00000090679.2
ENSMUST00000184986.1
Tac1
tachykinin 1
chr3_+_55461758 0.18 ENSMUST00000070418.4
Dclk1
doublecortin-like kinase 1
chr9_+_48495345 0.17 ENSMUST00000048824.7
Gm5617
predicted gene 5617
chr7_+_89980749 0.14 ENSMUST00000181784.1
Gm26529
predicted gene, 26529
chr4_+_84884366 0.11 ENSMUST00000102819.3
Cntln
centlein, centrosomal protein
chr2_+_74681991 0.11 ENSMUST00000142312.1
Hoxd11
homeobox D11
chr2_+_130196543 0.10 ENSMUST00000166774.2
Tmc2
transmembrane channel-like gene family 2
chr19_-_10604258 0.09 ENSMUST00000037678.6
Dak
dihydroxyacetone kinase 2 homolog (yeast)
chr17_+_78937124 0.09 ENSMUST00000024887.4
Ndufaf7
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor 7
chr7_-_46795881 0.09 ENSMUST00000107653.1
ENSMUST00000107654.1
ENSMUST00000014562.7
ENSMUST00000152759.1
Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chr1_+_66468364 0.08 ENSMUST00000061620.9
Unc80
unc-80 homolog (C. elegans)
chr12_+_102949450 0.07 ENSMUST00000179002.1
Unc79
unc-79 homolog (C. elegans)
chr1_+_153665627 0.07 ENSMUST00000147482.1
Rgs8
regulator of G-protein signaling 8
chr4_+_117849361 0.06 ENSMUST00000163288.1
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr5_+_32136458 0.06 ENSMUST00000031017.9
Fosl2
fos-like antigen 2
chr9_-_99710005 0.06 ENSMUST00000136429.1
Cldn18
claudin 18
chr19_-_37207293 0.04 ENSMUST00000132580.1
ENSMUST00000079754.4
ENSMUST00000136286.1
ENSMUST00000126188.1
ENSMUST00000126781.1
Cpeb3
cytoplasmic polyadenylation element binding protein 3
chrX_+_42151002 0.02 ENSMUST00000123245.1
Stag2
stromal antigen 2
chr12_-_11208948 0.01 ENSMUST00000049877.1
Msgn1
mesogenin 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 GO:0045013 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
1.8 7.3 GO:0034653 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
1.3 9.2 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
1.1 3.2 GO:2000040 regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.9 5.4 GO:1904075 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.7 2.6 GO:0048294 regulation of memory T cell differentiation(GO:0043380) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.6 1.7 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
0.4 1.2 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.4 2.7 GO:0008078 mesodermal cell migration(GO:0008078)
0.3 3.4 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.3 1.0 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.3 2.2 GO:0071896 protein localization to adherens junction(GO:0071896)
0.3 3.4 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.3 2.4 GO:0015871 choline transport(GO:0015871)
0.3 1.4 GO:0007386 compartment pattern specification(GO:0007386)
0.3 1.0 GO:0030091 protein repair(GO:0030091)
0.2 1.1 GO:0035262 gonad morphogenesis(GO:0035262)
0.2 0.7 GO:0032474 otolith morphogenesis(GO:0032474)
0.2 1.5 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.2 0.6 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.2 0.8 GO:0045872 regulation of rhodopsin gene expression(GO:0007468) positive regulation of rhodopsin gene expression(GO:0045872)
0.2 1.0 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.2 0.5 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.2 0.7 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.2 1.6 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 2.3 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 1.1 GO:0015671 oxygen transport(GO:0015671)
0.1 2.1 GO:0071318 cellular response to ATP(GO:0071318)
0.1 0.7 GO:0007403 glial cell fate determination(GO:0007403)
0.1 2.1 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.8 GO:0071638 adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163) negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.1 1.0 GO:2000318 positive regulation of T-helper 17 type immune response(GO:2000318)
0.1 1.5 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 1.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.6 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.1 1.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 1.6 GO:0006968 cellular defense response(GO:0006968)
0.1 2.6 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 0.6 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.1 0.5 GO:0033058 directional locomotion(GO:0033058)
0.1 0.6 GO:0032324 molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.1 0.2 GO:0045204 MAPK export from nucleus(GO:0045204)
0.1 1.6 GO:0015732 prostaglandin transport(GO:0015732)
0.1 0.6 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.1 0.4 GO:0070294 renal sodium ion absorption(GO:0070294) regulation of inward rectifier potassium channel activity(GO:1901979)
0.1 0.6 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.1 0.2 GO:0007412 axon target recognition(GO:0007412)
0.0 1.0 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.2 GO:2000851 positive regulation of glucocorticoid secretion(GO:2000851)
0.0 0.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.5 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 1.0 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.0 0.7 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 1.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.6 GO:0036159 inner dynein arm assembly(GO:0036159)
0.0 0.6 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 0.3 GO:0019348 dolichol metabolic process(GO:0019348)
0.0 0.7 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 1.0 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 1.3 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.5 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.9 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.4 GO:0007343 egg activation(GO:0007343)
0.0 0.5 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 0.5 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.4 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.7 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 2.0 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.0 0.4 GO:0015747 urate transport(GO:0015747)
0.0 1.3 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.1 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.3 GO:0048664 neuron fate determination(GO:0048664)
0.0 1.0 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 1.2 GO:0001662 behavioral fear response(GO:0001662)
0.0 0.3 GO:0019321 pentose metabolic process(GO:0019321)
0.0 0.6 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.7 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 4.2 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.6 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.1 GO:0035247 peptidyl-arginine omega-N-methylation(GO:0035247)
0.0 0.0 GO:1900248 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.0 0.1 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.4 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) insulin-like growth factor ternary complex(GO:0042567)
0.4 1.2 GO:0060205 secretory granule lumen(GO:0034774) cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
0.2 1.0 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.2 2.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 2.2 GO:0005916 fascia adherens(GO:0005916)
0.1 0.5 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 2.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 2.5 GO:0005922 connexon complex(GO:0005922)
0.1 0.9 GO:0000439 core TFIIH complex(GO:0000439)
0.1 7.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 0.9 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 0.6 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 2.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 0.7 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.4 GO:0005787 signal peptidase complex(GO:0005787)
0.1 1.0 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.6 GO:0036156 inner dynein arm(GO:0036156)
0.1 0.6 GO:0042629 mast cell granule(GO:0042629)
0.0 0.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.7 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 2.6 GO:0005657 replication fork(GO:0005657)
0.0 0.9 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.5 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 1.6 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.7 GO:0070469 respiratory chain(GO:0070469)
0.0 2.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.7 GO:0031201 SNARE complex(GO:0031201)
0.0 1.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0043034 costamere(GO:0043034)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.2 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
2.4 7.3 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.6 2.9 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.4 2.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.4 2.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.3 2.4 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.3 0.9 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.3 1.1 GO:0004096 catalase activity(GO:0004096)
0.2 1.0 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.2 2.1 GO:0046790 virion binding(GO:0046790)
0.2 0.7 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.2 0.6 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.2 1.9 GO:0001594 trace-amine receptor activity(GO:0001594)
0.2 2.6 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.2 1.0 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.2 1.4 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2 2.5 GO:0005243 gap junction channel activity(GO:0005243)
0.1 5.4 GO:0005159 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.1 3.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.5 GO:0031699 beta-3 adrenergic receptor binding(GO:0031699)
0.1 6.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 1.6 GO:0015245 fatty acid transporter activity(GO:0015245)
0.1 2.9 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.5 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.7 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.1 1.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 1.0 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 0.4 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.4 GO:0051373 FATZ binding(GO:0051373)
0.1 1.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 1.0 GO:0016004 phospholipase activator activity(GO:0016004)
0.1 0.3 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 1.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 0.2 GO:0070052 collagen V binding(GO:0070052)
0.1 0.3 GO:0097001 ceramide binding(GO:0097001)
0.1 0.8 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.9 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.5 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.5 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 1.2 GO:0008483 transaminase activity(GO:0008483)
0.0 0.6 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.9 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 1.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.6 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.4 GO:0031404 chloride ion binding(GO:0031404)
0.0 3.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 2.2 GO:0005080 protein kinase C binding(GO:0005080)
0.0 7.5 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.1 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.6 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 2.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.9 PID IGF1 PATHWAY IGF1 pathway
0.1 6.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 1.0 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 2.6 PID FOXO PATHWAY FoxO family signaling
0.0 2.1 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 2.2 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.6 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 2.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.3 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.7 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.6 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.0 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.5 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 9.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.3 7.3 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.2 2.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 5.9 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.6 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 2.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 2.2 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 2.1 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.9 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.7 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.6 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.7 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.9 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.5 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.9 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.6 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.5 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 1.3 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.6 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression