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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Spic

Z-value: 4.87

Motif logo

Transcription factors associated with Spic

Gene Symbol Gene ID Gene Info
ENSMUSG00000004359.10 Spi-C transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Spicmm10_v2_chr10_-_88683021_886830250.931.2e-16Click!

Activity profile of Spic motif

Sorted Z-values of Spic motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_106167564 37.33 ENSMUST00000063062.8
chitinase 3-like 3
chrX_-_7964166 33.57 ENSMUST00000128449.1
GATA binding protein 1
chr11_+_87793470 29.82 ENSMUST00000020779.4
myeloperoxidase
chr11_+_87793722 28.52 ENSMUST00000143021.2
myeloperoxidase
chr10_+_79879614 25.08 ENSMUST00000006679.8
proteinase 3
chr14_+_80000292 23.89 ENSMUST00000088735.3
olfactomedin 4
chr9_+_7558429 19.80 ENSMUST00000018765.2
matrix metallopeptidase 8
chr1_-_144775419 18.01 ENSMUST00000027603.3
regulator of G-protein signaling 18
chr8_+_70373541 17.24 ENSMUST00000003659.7
cartilage oligomeric matrix protein
chr7_-_122132844 16.16 ENSMUST00000106469.1
ENSMUST00000063587.6
ENSMUST00000106468.1
ENSMUST00000130149.1
ENSMUST00000098068.3
partner and localizer of BRCA2
chr7_-_100856289 15.47 ENSMUST00000139604.1
RELT tumor necrosis factor receptor
chrX_-_49788204 14.90 ENSMUST00000114893.1
immunoglobulin superfamily, member 1
chr1_+_40084764 14.67 ENSMUST00000027243.7
interleukin 1 receptor, type II
chrX_+_8271133 14.56 ENSMUST00000127103.1
ENSMUST00000115591.1
solute carrier family 38, member 5
chr11_+_98907801 14.01 ENSMUST00000092706.6
cell division cycle 6
chr11_+_32276400 13.87 ENSMUST00000020531.2
hemoglobin X, alpha-like embryonic chain in Hba complex
chr16_-_75909272 13.10 ENSMUST00000114239.2
SAM domain, SH3 domain and nuclear localization signals, 1
chr19_+_6084983 12.75 ENSMUST00000025704.2
cell division cycle associated 5
chr7_-_126704736 12.45 ENSMUST00000131415.1
coronin, actin binding protein 1A
chr7_+_43408187 12.13 ENSMUST00000005592.6
sialic acid binding Ig-like lectin G
chrX_+_8271381 11.91 ENSMUST00000033512.4
solute carrier family 38, member 5
chr13_-_110357136 11.90 ENSMUST00000058806.5
Grb2-binding adaptor, transmembrane
chr7_-_126704522 11.38 ENSMUST00000135087.1
coronin, actin binding protein 1A
chr9_+_56089962 10.98 ENSMUST00000059206.7
proline-serine-threonine phosphatase-interacting protein 1
chr5_-_138170992 10.93 ENSMUST00000139983.1
minichromosome maintenance deficient 7 (S. cerevisiae)
chr2_+_152847993 10.60 ENSMUST00000028969.8
TPX2, microtubule-associated protein homolog (Xenopus laevis)
chr11_-_102469839 10.60 ENSMUST00000103086.3
integrin alpha 2b
chr2_+_152847961 10.42 ENSMUST00000164120.1
ENSMUST00000178997.1
ENSMUST00000109816.1
TPX2, microtubule-associated protein homolog (Xenopus laevis)
chr7_+_28982832 10.40 ENSMUST00000085835.6
mitogen-activated protein kinase kinase kinase kinase 1
chr5_-_138171248 10.30 ENSMUST00000153867.1
minichromosome maintenance deficient 7 (S. cerevisiae)
chr7_-_126704179 10.26 ENSMUST00000106364.1
coronin, actin binding protein 1A
chr7_+_128062657 10.19 ENSMUST00000120355.1
ENSMUST00000106240.2
ENSMUST00000098015.3
integrin alpha M
chr7_-_127042420 10.07 ENSMUST00000032915.6
kinesin family member 22
chr15_+_78244781 9.94 ENSMUST00000096357.5
ENSMUST00000133618.1
neutrophil cytosolic factor 4
chr11_+_120948480 9.85 ENSMUST00000070653.6
solute carrier family 16 (monocarboxylic acid transporters), member 3
chr5_+_149265035 9.76 ENSMUST00000130144.1
ENSMUST00000071130.3
arachidonate 5-lipoxygenase activating protein
chr7_-_4725082 9.44 ENSMUST00000086363.4
ENSMUST00000086364.4
transmembrane protein 150B
chr5_-_138171216 9.27 ENSMUST00000147920.1
minichromosome maintenance deficient 7 (S. cerevisiae)
chr5_-_134229581 9.23 ENSMUST00000111275.1
ENSMUST00000016094.6
ENSMUST00000144086.1
neutrophil cytosolic factor 1
chr10_+_83722865 9.21 ENSMUST00000150459.1
RIKEN cDNA 1500009L16 gene
chr14_+_55765956 9.08 ENSMUST00000057569.3
leukotriene B4 receptor 1
chr13_+_30749226 8.85 ENSMUST00000021784.2
ENSMUST00000110307.1
interferon regulatory factor 4
chr6_-_136941694 8.72 ENSMUST00000032344.5
Rho, GDP dissociation inhibitor (GDI) beta
chr5_-_116024452 8.66 ENSMUST00000031486.7
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr10_+_75943020 8.65 ENSMUST00000121151.1
pre-B lymphocyte gene 3
chr3_-_105932664 8.58 ENSMUST00000098758.2
RIKEN cDNA I830077J02 gene
chr10_-_117282262 8.51 ENSMUST00000092163.7
lysozyme 2
chr10_+_115817247 8.48 ENSMUST00000035563.7
ENSMUST00000080630.3
ENSMUST00000179196.1
tetraspanin 8
chr2_-_165400398 8.35 ENSMUST00000029213.4
osteoclast stimulatory transmembrane protein
chr7_+_142460834 8.09 ENSMUST00000018963.4
ENSMUST00000105967.1
lymphocyte specific 1
chr3_+_103832562 7.91 ENSMUST00000062945.5
BCLl2-like 15
chr4_+_44300876 7.90 ENSMUST00000045607.5
maternal embryonic leucine zipper kinase
chr5_-_116024475 7.90 ENSMUST00000111999.1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr7_-_45239041 7.89 ENSMUST00000131290.1
CD37 antigen
chr7_+_128062698 7.82 ENSMUST00000119696.1
integrin alpha M
chr7_-_45238794 7.75 ENSMUST00000098461.1
ENSMUST00000107797.1
CD37 antigen
chr7_+_142460809 7.68 ENSMUST00000105968.1
lymphocyte specific 1
chr8_+_84701430 7.66 ENSMUST00000037165.4
lymphoblastomic leukemia 1
chr9_-_114781986 7.62 ENSMUST00000035009.8
ENSMUST00000084867.7
CKLF-like MARVEL transmembrane domain containing 7
chr10_-_30655859 7.62 ENSMUST00000092610.4
nuclear receptor coactivator 7
chr17_+_7925990 7.58 ENSMUST00000036370.7
T cell activation Rho GTPase activating protein
chr11_-_79523760 7.32 ENSMUST00000179322.1
ecotropic viral integration site 2b
chr17_+_34604262 7.31 ENSMUST00000174041.1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr4_-_133874682 7.07 ENSMUST00000168974.2
ribosomal protein S6 kinase polypeptide 1
chr11_-_17008647 7.03 ENSMUST00000102881.3
pleckstrin
chrX_+_20703906 7.02 ENSMUST00000033383.2
ubiquitin specific peptidase 11
chr2_+_22774081 6.95 ENSMUST00000014290.8
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr15_-_78305603 6.95 ENSMUST00000096356.3
colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
chr7_-_45239108 6.93 ENSMUST00000033063.6
CD37 antigen
chr8_-_122432924 6.87 ENSMUST00000017604.8
cytochrome b-245, alpha polypeptide
chr1_+_87620334 6.62 ENSMUST00000042275.8
ENSMUST00000168783.1
inositol polyphosphate-5-phosphatase D
chr2_+_24345282 6.62 ENSMUST00000114485.2
interleukin 1 receptor antagonist
chr1_+_87620306 6.40 ENSMUST00000169754.1
inositol polyphosphate-5-phosphatase D
chr6_-_136941887 6.37 ENSMUST00000111891.1
Rho, GDP dissociation inhibitor (GDI) beta
chr2_+_24345305 6.33 ENSMUST00000114482.1
interleukin 1 receptor antagonist
chr7_-_134232125 6.32 ENSMUST00000127524.1
a disintegrin and metallopeptidase domain 12 (meltrin alpha)
chr2_+_156840966 6.30 ENSMUST00000109564.1
TGFB-induced factor homeobox 2
chr7_-_134232005 6.29 ENSMUST00000134504.1
a disintegrin and metallopeptidase domain 12 (meltrin alpha)
chr17_+_57279094 6.16 ENSMUST00000169220.2
ENSMUST00000005889.9
ENSMUST00000112870.4
vav 1 oncogene
chr11_-_115133981 6.15 ENSMUST00000106561.1
ENSMUST00000051264.7
ENSMUST00000106562.2
CD300 antigen like family member F
chr17_-_6655939 6.13 ENSMUST00000179554.1
dynein light chain Tctex-type 1F
chr19_+_53529100 6.08 ENSMUST00000038287.6
dual specificity phosphatase 5
chr4_+_11758147 6.01 ENSMUST00000029871.5
ENSMUST00000108303.1
cadherin 17
chr17_-_6317474 5.99 ENSMUST00000169415.1
dynein light chain Tctex-type 1A
chr2_+_164805082 5.96 ENSMUST00000052107.4
zinc finger SWIM-type containing 3
chr5_+_34999111 5.92 ENSMUST00000114283.1
regulator of G-protein signaling 12
chr2_+_43748802 5.87 ENSMUST00000112824.1
ENSMUST00000055776.7
Rho GTPase activating protein 15
chr9_-_20644726 5.82 ENSMUST00000148631.1
ENSMUST00000131128.1
ENSMUST00000151861.1
ENSMUST00000131343.1
ENSMUST00000086458.3
F-box and leucine-rich repeat protein 12
chr5_+_4192367 5.70 ENSMUST00000177258.1
predicted gene 9897
chr5_+_34999046 5.69 ENSMUST00000114281.1
regulator of G-protein signaling 12
chr8_+_117498272 5.65 ENSMUST00000081232.7
phospholipase C, gamma 2
chr10_+_130322845 5.64 ENSMUST00000042586.8
thymocyte expressed, positive selection associated 1
chr6_-_136941494 5.59 ENSMUST00000111892.1
Rho, GDP dissociation inhibitor (GDI) beta
chr2_+_36216749 5.48 ENSMUST00000147012.1
ENSMUST00000122948.1
predicted gene 13431
chr12_-_32208470 5.43 ENSMUST00000085469.5
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr2_+_120463566 5.42 ENSMUST00000028749.7
ENSMUST00000110721.1
calpain 3
chr5_-_3893907 5.41 ENSMUST00000117463.1
ENSMUST00000044746.4
mitochondrial transcription termination factor
chr4_+_130913264 5.39 ENSMUST00000156225.1
ENSMUST00000156742.1
lysosomal-associated protein transmembrane 5
chr14_+_116925516 5.39 ENSMUST00000125435.1
glypican 6
chr1_-_171234290 5.16 ENSMUST00000079957.6
Fc receptor, IgE, high affinity I, gamma polypeptide
chr7_-_19271797 5.15 ENSMUST00000032561.8
vasodilator-stimulated phosphoprotein
chr1_-_170927567 5.14 ENSMUST00000046322.7
ENSMUST00000159171.1
Fc receptor-like A
chr3_-_67463828 5.09 ENSMUST00000058981.2
latexin
chr12_-_11265768 5.03 ENSMUST00000166117.1
Gen homolog 1, endonuclease (Drosophila)
chr14_+_57524734 5.03 ENSMUST00000089494.4
interleukin 17D
chr1_-_149961230 5.02 ENSMUST00000070200.8
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr19_+_4154606 4.99 ENSMUST00000061086.8
protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
chr2_+_91650116 4.99 ENSMUST00000111331.2
Rho GTPase activating protein 1
chr15_+_103453782 4.93 ENSMUST00000047405.7
NCK associated protein 1 like
chr7_+_28440927 4.90 ENSMUST00000078845.6
glia maturation factor, gamma
chr1_+_152807877 4.80 ENSMUST00000027754.6
neutrophil cytosolic factor 2
chrX_-_136085206 4.80 ENSMUST00000138878.1
ENSMUST00000080929.6
nuclear RNA export factor 3
chr1_-_20820213 4.72 ENSMUST00000053266.9
minichromosome maintenance deficient 3 (S. cerevisiae)
chr12_-_78980758 4.70 ENSMUST00000174072.1
transmembrane protein 229B
chr15_-_66812593 4.70 ENSMUST00000100572.3
src-like adaptor
chr7_+_126584937 4.66 ENSMUST00000039522.6
apolipoprotein B receptor
chr3_-_101029543 4.62 ENSMUST00000147399.2
CD101 antigen
chr17_+_47594629 4.61 ENSMUST00000182846.1
cyclin D3
chr6_-_124733067 4.60 ENSMUST00000173647.1
protein tyrosine phosphatase, non-receptor type 6
chr1_-_170927540 4.59 ENSMUST00000162136.1
ENSMUST00000162887.1
Fc receptor-like A
chr12_-_32208609 4.58 ENSMUST00000053215.7
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr2_+_164074122 4.57 ENSMUST00000018353.7
serine/threonine kinase 4
chr2_-_105399286 4.54 ENSMUST00000006128.6
reticulocalbin 1
chr6_+_123229843 4.52 ENSMUST00000112554.2
ENSMUST00000024118.4
ENSMUST00000117130.1
C-type lectin domain family 4, member n
chr17_+_29360923 4.50 ENSMUST00000024810.6
FYVE, RhoGEF and PH domain containing 2
chr9_-_77045788 4.50 ENSMUST00000034911.6
tubulointerstitial nephritis antigen
chr9_+_109875541 4.47 ENSMUST00000094324.3
cell division cycle 25A
chr11_+_70505244 4.44 ENSMUST00000019063.2
transmembrane 4 superfamily member 5
chr3_+_88621102 4.42 ENSMUST00000029694.7
ENSMUST00000176804.1
rho/rac guanine nucleotide exchange factor (GEF) 2
chr4_+_115839192 4.38 ENSMUST00000019677.5
ENSMUST00000144427.1
ENSMUST00000106513.3
ENSMUST00000130819.1
ENSMUST00000151203.1
ENSMUST00000140315.1
MAP kinase-interacting serine/threonine kinase 1
chr17_-_33955658 4.37 ENSMUST00000174609.2
ENSMUST00000008812.7
ribosomal protein S18
chr4_+_130913120 4.25 ENSMUST00000151698.1
lysosomal-associated protein transmembrane 5
chr2_+_91650169 4.23 ENSMUST00000090614.4
Rho GTPase activating protein 1
chr13_-_97137877 4.21 ENSMUST00000073456.7
NSA2 ribosome biogenesis homolog (S. cerevisiae)
chr3_+_87376381 4.20 ENSMUST00000163661.1
ENSMUST00000072480.2
ENSMUST00000167200.1
Fc receptor-like 1
chr6_+_5725639 4.12 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
dynein cytoplasmic 1 intermediate chain 1
chr5_-_99978914 4.00 ENSMUST00000112939.3
ENSMUST00000171786.1
ENSMUST00000072750.6
ENSMUST00000019128.8
ENSMUST00000172361.1
heterogeneous nuclear ribonucleoprotein D
chr17_+_48316141 4.00 ENSMUST00000049614.6
RIKEN cDNA B430306N03 gene
chr9_+_106222598 4.00 ENSMUST00000062241.9
toll-like receptor 9
chr11_+_69914179 3.99 ENSMUST00000057884.5
G protein pathway suppressor 2
chr13_-_49309217 3.96 ENSMUST00000110087.2
FYVE, RhoGEF and PH domain containing 3
chr4_+_140701466 3.91 ENSMUST00000038893.5
ENSMUST00000138808.1
regulator of chromosome condensation 2
chr3_+_109123104 3.89 ENSMUST00000029477.6
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24
chr4_-_41314877 3.89 ENSMUST00000030145.8
DDB1 and CUL4 associated factor 12
chr5_+_34999070 3.88 ENSMUST00000114280.1
regulator of G-protein signaling 12
chr3_+_105904377 3.86 ENSMUST00000000574.1
adenosine A3 receptor
chr2_+_119112793 3.84 ENSMUST00000140939.1
ENSMUST00000028795.3
RAD51 homolog
chr12_+_98268626 3.77 ENSMUST00000075072.4
G-protein coupled receptor 65
chr11_+_70130329 3.76 ENSMUST00000041550.5
ENSMUST00000165951.1
macrophage galactose N-acetyl-galactosamine specific lectin 2
chr1_-_33669745 3.76 ENSMUST00000027312.9
DNA primase, p58 subunit
chr1_-_37496095 3.71 ENSMUST00000148047.1
ENSMUST00000143636.1
mannoside acetylglucosaminyltransferase 4, isoenzyme A
chr7_-_35396708 3.67 ENSMUST00000154597.1
ENSMUST00000032704.5
RIKEN cDNA C230052I12 gene
chr17_+_6601671 3.66 ENSMUST00000092966.4
dynein light chain Tctex-type 1C
chr6_-_67376147 3.60 ENSMUST00000018485.3
interleukin 12 receptor, beta 2
chr18_+_67562387 3.57 ENSMUST00000163749.1
predicted gene, 17669
chr7_-_104369782 3.56 ENSMUST00000164410.1
tripartite motif-containing 30B
chr9_+_108508005 3.56 ENSMUST00000006838.8
ENSMUST00000134939.1
glutaminyl-tRNA synthetase
chr1_+_179546303 3.53 ENSMUST00000040706.8
consortin, connexin sorting protein
chr5_-_38876693 3.50 ENSMUST00000169819.1
ENSMUST00000171633.1
cytokine-dependent hematopoietic cell linker
chr1_-_52232296 3.48 ENSMUST00000114512.1
glutaminase
chr7_-_19604444 3.47 ENSMUST00000086041.5
CLK4-associating serine/arginine rich protein
chr19_+_4878671 3.44 ENSMUST00000006632.7
zinc finger, DHHC domain containing 24
chr3_+_24333046 3.38 ENSMUST00000077389.6
predicted gene 7536
chr5_-_137116177 3.35 ENSMUST00000054384.5
ENSMUST00000152207.1
tripartite motif-containing 56
chr4_-_117891994 3.27 ENSMUST00000030265.3
DPH2 homolog (S. cerevisiae)
chr1_+_191325912 3.27 ENSMUST00000027940.5
transmembrane protein 206
chr16_+_91406235 3.25 ENSMUST00000023691.5
interleukin 10 receptor, beta
chr8_+_94923687 3.19 ENSMUST00000153448.1
ENSMUST00000074570.3
ENSMUST00000166802.1
G protein-coupled receptor 114
chr8_-_70897407 3.18 ENSMUST00000054220.8
ribosomal protein L18A
chr2_-_91649785 3.12 ENSMUST00000111333.1
zinc finger protein 408
chr11_-_69323768 3.10 ENSMUST00000092973.5
centrobin, centrosomal BRCA2 interacting protein
chr5_+_108065742 3.08 ENSMUST00000081567.4
ENSMUST00000170319.1
ENSMUST00000112626.1
metal response element binding transcription factor 2
chr5_+_86071734 3.06 ENSMUST00000031171.7
signal transducing adaptor family member 1
chr14_+_30479565 3.05 ENSMUST00000022535.7
DCP1 decapping enzyme homolog A (S. cerevisiae)
chr7_+_131032061 3.04 ENSMUST00000084509.3
deleted in malignant brain tumors 1
chr12_-_24493656 2.97 ENSMUST00000073088.2
predicted pseudogene 16372
chr1_+_136683375 2.96 ENSMUST00000181524.1
predicted gene, 19705
chr12_+_77238093 2.95 ENSMUST00000177595.1
ENSMUST00000171770.2
fucosyltransferase 8
chr1_-_171059390 2.93 ENSMUST00000164044.1
ENSMUST00000169017.1
Fc receptor, IgG, low affinity III
chr7_-_100964371 2.92 ENSMUST00000060174.4
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr17_+_35135463 2.89 ENSMUST00000173535.1
ENSMUST00000173952.1
BCL2-associated athanogene 6
chr10_-_89443888 2.87 ENSMUST00000099374.2
ENSMUST00000105298.1
growth arrest-specific 2 like 3
chr11_+_120458093 2.84 ENSMUST00000058370.7
ENSMUST00000175970.1
ENSMUST00000176120.1
coiled-coil domain containing 137
chr16_-_36642742 2.82 ENSMUST00000135280.1
CD86 antigen
chr11_-_98400453 2.80 ENSMUST00000090827.5
post-GPI attachment to proteins 3
chr10_-_44458687 2.77 ENSMUST00000105490.2
PR domain containing 1, with ZNF domain
chr15_+_39745926 2.77 ENSMUST00000022913.4
dentrocyte expressed seven transmembrane protein
chr19_-_56389877 2.75 ENSMUST00000166203.1
ENSMUST00000167239.1
ENSMUST00000040711.8
ENSMUST00000095947.4
ENSMUST00000073536.6
nebulin-related anchoring protein
chr10_-_80102653 2.73 ENSMUST00000042771.7
strawberry notch homolog 2 (Drosophila)
chr7_+_28540863 2.71 ENSMUST00000119180.2
syncollin
chr2_-_91649751 2.71 ENSMUST00000099714.3
zinc finger protein 408
chr8_+_94666722 2.67 ENSMUST00000034228.8
ADP-ribosylation factor-like 2 binding protein
chr19_-_40994133 2.64 ENSMUST00000117695.1
B cell linker
chr2_-_84670727 2.63 ENSMUST00000117299.2
RIKEN cDNA 2700094K13 gene
chr11_-_98400393 2.63 ENSMUST00000128897.1
post-GPI attachment to proteins 3
chr1_-_150164943 2.62 ENSMUST00000181308.1
predicted gene, 26687
chr2_-_167492826 2.61 ENSMUST00000109211.2
ENSMUST00000057627.9
spermatogenesis associated 2
chr11_-_102880981 2.59 ENSMUST00000107060.1
elongation factor Tu GTP binding domain containing 2
chr6_+_137410721 2.55 ENSMUST00000167002.1
protein tyrosine phosphatase, receptor type, O
chr2_-_93046053 2.53 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
PR domain containing 11

Network of associatons between targets according to the STRING database.

First level regulatory network of Spic

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
19.4 58.3 GO:0002148 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
11.2 33.6 GO:0030221 basophil differentiation(GO:0030221)
5.7 34.1 GO:0032796 uropod organization(GO:0032796)
5.5 27.6 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
5.0 25.1 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
4.2 12.7 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
3.5 14.0 GO:0006742 NADP catabolic process(GO:0006742)
3.4 34.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
3.3 13.0 GO:0045659 negative regulation of neutrophil differentiation(GO:0045659)
3.1 15.5 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
2.9 8.8 GO:0045404 interleukin-10 biosynthetic process(GO:0042091) interleukin-13 biosynthetic process(GO:0042231) regulation of interleukin-10 biosynthetic process(GO:0045074) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
2.8 11.1 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
2.6 20.7 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
2.6 18.0 GO:0014004 microglia differentiation(GO:0014004) microglia development(GO:0014005)
2.5 7.6 GO:0002337 B-1a B cell differentiation(GO:0002337)
2.4 9.8 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
2.4 9.5 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
2.3 6.9 GO:0002019 regulation of renal output by angiotensin(GO:0002019)
2.3 22.6 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
2.1 6.2 GO:0035666 TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
2.0 6.0 GO:0002314 germinal center B cell differentiation(GO:0002314)
2.0 4.0 GO:0032741 positive regulation of interleukin-18 production(GO:0032741)
1.9 5.6 GO:0010387 COP9 signalosome assembly(GO:0010387)
1.8 5.4 GO:0070315 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) G1 to G0 transition involved in cell differentiation(GO:0070315)
1.7 13.9 GO:0015671 oxygen transport(GO:0015671)
1.7 5.1 GO:0033082 regulation of extrathymic T cell differentiation(GO:0033082)
1.6 4.9 GO:0071846 actin filament debranching(GO:0071846)
1.6 4.7 GO:0072717 cellular response to actinomycin D(GO:0072717)
1.5 9.2 GO:0032439 endosome localization(GO:0032439) negative regulation of vacuolar transport(GO:1903336)
1.5 26.5 GO:0015816 glycine transport(GO:0015816)
1.4 10.0 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
1.4 7.0 GO:0070560 negative regulation of inositol phosphate biosynthetic process(GO:0010920) protein secretion by platelet(GO:0070560)
1.4 4.2 GO:0032685 negative regulation of granulocyte macrophage colony-stimulating factor production(GO:0032685)
1.4 15.3 GO:0035878 nail development(GO:0035878)
1.4 4.1 GO:0007439 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
1.2 4.9 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
1.2 3.5 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
1.2 3.5 GO:0070476 rRNA (guanine-N7)-methylation(GO:0070476)
1.2 5.8 GO:0033277 abortive mitotic cell cycle(GO:0033277)
1.2 6.9 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
1.2 6.9 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
1.2 4.6 GO:0010847 regulation of chromatin assembly(GO:0010847)
1.1 4.6 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
1.1 5.6 GO:0032237 activation of store-operated calcium channel activity(GO:0032237)
1.1 7.7 GO:0001955 blood vessel maturation(GO:0001955)
1.1 8.6 GO:0036506 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
1.0 3.1 GO:1903969 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
1.0 5.1 GO:0002309 T cell proliferation involved in immune response(GO:0002309)
1.0 3.0 GO:1901355 response to rapamycin(GO:1901355)
1.0 3.0 GO:1904569 regulation of selenocysteine incorporation(GO:1904569)
1.0 18.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.0 9.9 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.9 2.8 GO:0002644 negative regulation of tolerance induction(GO:0002644)
0.9 3.8 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.9 1.8 GO:0042494 detection of bacterial lipoprotein(GO:0042494)
0.9 8.7 GO:0051025 negative regulation of immunoglobulin secretion(GO:0051025)
0.8 5.0 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.8 3.3 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.8 17.5 GO:0051984 positive regulation of chromosome segregation(GO:0051984)
0.8 7.1 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.8 3.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.7 2.9 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.7 5.0 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.7 4.0 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.6 3.9 GO:0015867 ATP transport(GO:0015867)
0.6 7.6 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.6 1.9 GO:1904732 regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.6 8.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.6 1.8 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.6 3.5 GO:0006543 glutamine catabolic process(GO:0006543)
0.6 4.4 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.5 13.1 GO:0030574 collagen catabolic process(GO:0030574)
0.5 2.7 GO:0072675 osteoclast fusion(GO:0072675)
0.5 13.4 GO:0003417 growth plate cartilage development(GO:0003417)
0.5 1.6 GO:2000556 regulation of T-helper 1 cell cytokine production(GO:2000554) positive regulation of T-helper 1 cell cytokine production(GO:2000556)
0.5 7.3 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.5 4.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.5 2.5 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.5 10.1 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.5 0.9 GO:0046136 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.5 2.3 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.4 2.2 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.4 3.1 GO:1902410 mitotic cytokinetic process(GO:1902410)
0.4 23.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.4 3.9 GO:0002441 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.4 0.9 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.4 2.5 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.4 0.8 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.4 6.1 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.4 9.9 GO:0045730 respiratory burst(GO:0045730)
0.4 3.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.4 4.1 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.4 12.1 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.4 2.9 GO:0030321 transepithelial chloride transport(GO:0030321)
0.4 1.4 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.3 1.0 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.3 1.7 GO:0035633 cyclooxygenase pathway(GO:0019371) maintenance of blood-brain barrier(GO:0035633)
0.3 1.4 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.3 1.0 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.3 1.0 GO:0034379 very-low-density lipoprotein particle assembly(GO:0034379)
0.3 0.7 GO:0035419 negative regulation of toll-like receptor 2 signaling pathway(GO:0034136) activation of MAPK activity involved in innate immune response(GO:0035419)
0.3 1.3 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.3 1.6 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.3 0.9 GO:0007208 phospholipase C-activating serotonin receptor signaling pathway(GO:0007208)
0.3 1.5 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.3 1.5 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.3 6.3 GO:0038092 nodal signaling pathway(GO:0038092)
0.3 1.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.3 1.1 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.3 1.7 GO:0071543 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.3 1.9 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.3 1.5 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.3 4.8 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.2 4.6 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.2 17.2 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.2 5.1 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.2 1.7 GO:1904851 protein localization to nuclear body(GO:1903405) positive regulation of establishment of protein localization to telomere(GO:1904851) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.2 2.1 GO:0051014 actin filament severing(GO:0051014)
0.2 5.0 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.2 4.7 GO:0006270 DNA replication initiation(GO:0006270)
0.2 1.4 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.2 2.4 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.2 4.0 GO:0009651 response to salt stress(GO:0009651)
0.2 4.5 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.2 3.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.2 1.7 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.2 3.8 GO:0010447 response to acidic pH(GO:0010447)
0.2 0.7 GO:0007000 nucleolus organization(GO:0007000)
0.2 0.2 GO:0061738 late endosomal microautophagy(GO:0061738)
0.2 4.2 GO:0043486 histone exchange(GO:0043486)
0.2 0.5 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.2 4.9 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.2 1.5 GO:0048251 elastic fiber assembly(GO:0048251)
0.2 8.5 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 1.8 GO:0045651 positive regulation of granulocyte differentiation(GO:0030854) positive regulation of macrophage differentiation(GO:0045651)
0.1 1.6 GO:0035330 regulation of hippo signaling(GO:0035330)
0.1 1.1 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.1 3.3 GO:0051764 actin filament network formation(GO:0051639) actin crosslink formation(GO:0051764)
0.1 9.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 1.2 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.6 GO:1902167 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902167)
0.1 1.7 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.1 0.9 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 5.4 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 1.5 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1 6.1 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.1 0.7 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.1 1.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 3.2 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.1 12.4 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.1 3.7 GO:0002763 positive regulation of myeloid leukocyte differentiation(GO:0002763)
0.1 2.5 GO:0034508 centromere complex assembly(GO:0034508)
0.1 0.2 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.1 2.0 GO:0002504 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.1 1.1 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.1 4.0 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.1 1.5 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.1 2.2 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.1 0.8 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.1 0.3 GO:1903984 regulation of TRAIL-activated apoptotic signaling pathway(GO:1903121) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) negative regulation of metalloendopeptidase activity(GO:1904684)
0.1 1.2 GO:0001522 pseudouridine synthesis(GO:0001522)
0.1 4.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 1.0 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.1 2.6 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.1 1.2 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.1 0.7 GO:0003283 atrial septum development(GO:0003283)
0.1 0.2 GO:0044565 dendritic cell proliferation(GO:0044565)
0.1 3.6 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
0.1 8.9 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 4.9 GO:0051289 protein homotetramerization(GO:0051289)
0.1 1.5 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 6.3 GO:0000910 cytokinesis(GO:0000910)
0.0 1.2 GO:0050832 defense response to fungus(GO:0050832)
0.0 2.3 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 6.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.3 GO:0051013 microtubule severing(GO:0051013)
0.0 1.1 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.6 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.9 GO:0031529 ruffle organization(GO:0031529)
0.0 4.8 GO:0051607 defense response to virus(GO:0051607)
0.0 0.4 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.0 0.5 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 9.3 GO:0006935 chemotaxis(GO:0006935)
0.0 0.5 GO:0006298 mismatch repair(GO:0006298)
0.0 0.5 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 2.2 GO:0016579 protein deubiquitination(GO:0016579)
0.0 1.5 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 1.2 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 5.7 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 3.3 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 1.6 GO:0000956 nuclear-transcribed mRNA catabolic process(GO:0000956)
0.0 2.4 GO:0032496 response to lipopolysaccharide(GO:0032496)
0.0 0.5 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.0 0.7 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.0 0.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.1 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.5 GO:0006958 complement activation, classical pathway(GO:0006958)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 58.3 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
2.9 11.5 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
2.8 30.8 GO:0043020 NADPH oxidase complex(GO:0043020)
2.6 21.0 GO:0005818 aster(GO:0005818)
2.5 25.4 GO:0042581 specific granule(GO:0042581)
2.3 35.2 GO:0042555 MCM complex(GO:0042555)
2.1 2.1 GO:0070820 tertiary granule(GO:0070820)
1.7 13.9 GO:0005833 hemoglobin complex(GO:0005833)
1.6 4.8 GO:0042272 nuclear RNA export factor complex(GO:0042272)
1.5 9.2 GO:0097443 sorting endosome(GO:0097443)
1.5 34.1 GO:0032426 stereocilium tip(GO:0032426)
1.4 8.5 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
1.4 12.7 GO:0008278 cohesin complex(GO:0008278)
1.4 4.1 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
1.4 11.0 GO:0005826 actomyosin contractile ring(GO:0005826)
1.2 8.6 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
1.1 3.3 GO:0032127 dense core granule membrane(GO:0032127)
1.0 4.0 GO:0036019 endolysosome(GO:0036019)
0.8 4.1 GO:1990745 EARP complex(GO:1990745)
0.8 3.0 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.8 3.8 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.7 6.9 GO:0042101 T cell receptor complex(GO:0042101)
0.7 29.0 GO:0008305 integrin complex(GO:0008305)
0.6 5.8 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.5 19.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.5 2.1 GO:0032021 NELF complex(GO:0032021)
0.5 1.6 GO:0097543 ciliary inversin compartment(GO:0097543)
0.5 15.3 GO:0051233 spindle midzone(GO:0051233)
0.5 2.8 GO:0005927 muscle tendon junction(GO:0005927)
0.4 20.7 GO:0001772 immunological synapse(GO:0001772)
0.4 12.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.4 4.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.4 1.5 GO:0097450 astrocyte end-foot(GO:0097450)
0.3 38.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 13.4 GO:0097440 apical dendrite(GO:0097440)
0.3 4.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.3 3.0 GO:0005642 annulate lamellae(GO:0005642)
0.3 0.8 GO:0071001 U4/U6 snRNP(GO:0071001)
0.3 12.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 8.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 1.4 GO:0070847 core mediator complex(GO:0070847)
0.2 1.6 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.2 4.7 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.2 2.9 GO:0031209 SCAR complex(GO:0031209)
0.2 1.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.2 2.7 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.2 14.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 3.8 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.2 3.2 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.2 2.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 3.5 GO:0042588 zymogen granule(GO:0042588)
0.2 1.0 GO:0098651 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.2 0.9 GO:0005663 DNA replication factor C complex(GO:0005663)
0.2 5.2 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 6.5 GO:0002102 podosome(GO:0002102)
0.1 2.2 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 0.4 GO:0070985 TFIIK complex(GO:0070985)
0.1 3.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 68.6 GO:0031012 extracellular matrix(GO:0031012)
0.1 7.0 GO:0005871 kinesin complex(GO:0005871)
0.1 1.7 GO:0031011 Ino80 complex(GO:0031011)
0.1 4.1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.8 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 5.4 GO:0030315 T-tubule(GO:0030315)
0.1 3.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 3.7 GO:0035861 site of double-strand break(GO:0035861)
0.1 1.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 0.7 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 3.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 11.6 GO:0030863 cortical cytoskeleton(GO:0030863)
0.1 4.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 1.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.6 GO:0034709 methylosome(GO:0034709)
0.1 1.4 GO:0030667 secretory granule membrane(GO:0030667)
0.1 1.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 19.1 GO:0031965 nuclear membrane(GO:0031965)
0.1 1.5 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 5.7 GO:0032587 ruffle membrane(GO:0032587)
0.1 2.5 GO:0005795 Golgi stack(GO:0005795)
0.1 1.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 0.2 GO:0055087 Ski complex(GO:0055087)
0.1 0.5 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 1.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 4.3 GO:0030175 filopodium(GO:0030175)
0.1 2.5 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.3 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 63.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 2.1 GO:0001726 ruffle(GO:0001726)
0.0 1.0 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.0 GO:0005903 brush border(GO:0005903)
0.0 4.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 5.3 GO:0001650 fibrillar center(GO:0001650)
0.0 3.1 GO:0005814 centriole(GO:0005814)
0.0 3.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 3.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.5 GO:0000776 kinetochore(GO:0000776)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 6.7 GO:0005911 cell-cell junction(GO:0005911)
0.0 3.2 GO:0005938 cell cortex(GO:0005938)
0.0 0.6 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.5 GO:0005581 collagen trimer(GO:0005581)
0.0 8.1 GO:0009986 cell surface(GO:0009986)
0.0 38.7 GO:0005886 plasma membrane(GO:0005886)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.7 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
4.3 12.9 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353)
3.3 9.8 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
2.7 24.0 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
2.6 20.7 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
2.6 18.0 GO:0001851 complement component C3b binding(GO:0001851)
2.5 17.2 GO:0005499 vitamin D binding(GO:0005499)
2.3 21.0 GO:0061676 importin-alpha family protein binding(GO:0061676)
2.3 9.1 GO:0004974 leukotriene receptor activity(GO:0004974)
2.2 13.0 GO:0051425 PTB domain binding(GO:0051425)
2.1 10.6 GO:0070051 fibrinogen binding(GO:0070051)
2.1 33.6 GO:0008301 DNA binding, bending(GO:0008301)
2.1 6.2 GO:0005136 interleukin-4 receptor binding(GO:0005136)
2.0 6.0 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
1.9 26.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
1.7 13.9 GO:0005344 oxygen transporter activity(GO:0005344)
1.7 14.9 GO:0034711 inhibin binding(GO:0034711)
1.5 34.1 GO:0032036 myosin heavy chain binding(GO:0032036)
1.5 1.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
1.4 9.9 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
1.3 5.2 GO:0019767 IgE receptor activity(GO:0019767)
1.0 3.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
1.0 2.9 GO:0015065 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.9 10.0 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.9 7.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.9 54.4 GO:0004601 peroxidase activity(GO:0004601)
0.9 6.9 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.8 2.5 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.8 4.7 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.7 29.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.7 10.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.7 5.2 GO:0045322 unmethylated CpG binding(GO:0045322)
0.7 5.8 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.6 8.5 GO:0003796 lysozyme activity(GO:0003796)
0.6 3.5 GO:0004359 glutaminase activity(GO:0004359)
0.6 2.3 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.6 5.0 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.5 3.8 GO:0000150 recombinase activity(GO:0000150)
0.5 12.5 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.5 8.6 GO:0015643 toxic substance binding(GO:0015643)
0.5 3.0 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.5 15.5 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.5 3.7 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.5 3.2 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.4 4.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.4 1.3 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.4 4.9 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.4 6.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.4 4.0 GO:0051434 BH3 domain binding(GO:0051434)
0.4 5.2 GO:0005522 profilin binding(GO:0005522)
0.4 24.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.4 3.0 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.4 7.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.4 5.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.4 3.5 GO:0071253 connexin binding(GO:0071253)
0.3 1.4 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.3 5.4 GO:0031432 titin binding(GO:0031432)
0.3 17.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 3.9 GO:0000295 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) purine nucleotide transmembrane transporter activity(GO:0015216) ADP transmembrane transporter activity(GO:0015217)
0.3 6.0 GO:0017166 vinculin binding(GO:0017166)
0.3 3.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.3 3.0 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.3 1.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.3 4.0 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.3 1.7 GO:0034432 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.3 12.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3 1.6 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.3 7.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 2.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 1.9 GO:0016531 copper chaperone activity(GO:0016531)
0.2 4.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 2.9 GO:0008417 fucosyltransferase activity(GO:0008417)
0.2 43.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 7.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2 0.6 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.2 1.8 GO:0043394 proteoglycan binding(GO:0043394)
0.2 0.2 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.2 0.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.2 7.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 0.8 GO:0089720 caspase binding(GO:0089720)
0.2 8.8 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.2 0.8 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 4.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 1.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 45.0 GO:0005096 GTPase activator activity(GO:0005096)
0.1 2.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 5.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 4.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 2.1 GO:0015299 solute:proton antiporter activity(GO:0015299)
0.1 1.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 1.6 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 4.9 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 7.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.5 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 4.5 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 3.0 GO:0070840 dynein complex binding(GO:0070840)
0.1 5.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 0.9 GO:0043142 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1 7.4 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.1 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.1 3.6 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 2.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 0.6 GO:0008823 ferric-chelate reductase activity(GO:0000293) cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 8.5 GO:0005178 integrin binding(GO:0005178)
0.1 1.3 GO:0008143 poly(A) binding(GO:0008143)
0.1 4.4 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) ATP-dependent helicase activity(GO:0008026) RNA-dependent ATPase activity(GO:0008186) purine NTP-dependent helicase activity(GO:0070035)
0.1 4.7 GO:0004386 helicase activity(GO:0004386)
0.1 0.8 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.5 GO:0051400 BH domain binding(GO:0051400)
0.1 17.0 GO:0045296 cadherin binding(GO:0045296)
0.1 2.7 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 1.5 GO:0071949 FAD binding(GO:0071949)
0.1 3.3 GO:0035064 methylated histone binding(GO:0035064)
0.1 5.8 GO:0017124 SH3 domain binding(GO:0017124)
0.1 1.2 GO:0017091 AU-rich element binding(GO:0017091)
0.0 26.7 GO:0003779 actin binding(GO:0003779)
0.0 2.6 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 3.1 GO:0019894 kinesin binding(GO:0019894)
0.0 0.7 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 4.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 4.1 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 26.0 GO:0003682 chromatin binding(GO:0003682)
0.0 1.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.1 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.6 GO:0032183 SUMO binding(GO:0032183)
0.0 2.5 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 2.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 3.1 GO:0051087 chaperone binding(GO:0051087)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)
0.0 1.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 6.7 GO:0005125 cytokine activity(GO:0005125)
0.0 0.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 1.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.0 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 1.9 GO:0042393 histone binding(GO:0042393)
0.0 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 3.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.5 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.0 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.0 0.5 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.2 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 1.8 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 59.3 PID IL23 PATHWAY IL23-mediated signaling events
1.1 53.8 PID ATR PATHWAY ATR signaling pathway
0.9 29.0 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.8 12.5 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.6 24.5 PID EPO PATHWAY EPO signaling pathway
0.5 15.9 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.5 16.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.5 20.6 PID AURORA A PATHWAY Aurora A signaling
0.5 15.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.5 32.9 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.4 15.9 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.4 15.2 PID IL1 PATHWAY IL1-mediated signaling events
0.4 10.0 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.3 17.6 PID LKB1 PATHWAY LKB1 signaling events
0.3 24.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.3 15.4 PID RAC1 PATHWAY RAC1 signaling pathway
0.3 3.6 PID IL27 PATHWAY IL27-mediated signaling events
0.2 5.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 4.0 PID IL6 7 PATHWAY IL6-mediated signaling events
0.2 22.7 PID CMYB PATHWAY C-MYB transcription factor network
0.2 8.4 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 4.6 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.2 10.7 SIG CHEMOTAXIS Genes related to chemotaxis
0.2 2.4 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.2 8.8 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 2.8 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 4.0 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 5.3 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 26.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 9.4 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 0.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.6 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 1.7 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 5.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 4.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.1 4.1 PID P53 REGULATION PATHWAY p53 pathway
0.1 1.0 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 1.4 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 0.7 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.9 PID ARF 3PATHWAY Arf1 pathway
0.0 8.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 5.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 PID FGF PATHWAY FGF signaling pathway
0.0 0.7 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 2.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 4.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 35.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
1.5 4.5 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
1.3 14.0 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
1.0 17.5 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.8 11.0 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.8 12.5 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.7 9.9 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.6 16.2 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.6 26.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.5 28.5 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.5 2.8 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.4 5.8 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.4 16.8 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.4 5.8 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.4 11.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.4 3.8 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.4 4.4 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.3 7.0 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.3 9.2 REACTOME ACYL CHAIN REMODELLING OF PC Genes involved in Acyl chain remodelling of PC
0.3 16.8 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.3 8.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 4.3 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.3 7.1 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.3 2.6 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.3 53.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.3 7.4 REACTOME KINESINS Genes involved in Kinesins
0.3 4.6 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.3 14.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3 3.4 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3 30.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 6.7 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.2 16.0 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.2 3.5 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 12.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.2 2.6 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2 6.3 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2 4.6 REACTOME G1 PHASE Genes involved in G1 Phase
0.2 4.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 7.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 5.4 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.2 4.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 31.2 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 5.6 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 1.6 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 5.2 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 0.6 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 2.9