ISMARA results: Sox2

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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Sox2

Z-value: 3.20

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Transcription factors associated with Sox2

Gene Symbol	Gene ID	Gene Info
Sox2 Ensembl NCBI MGI UniProt	ENSMUSG00000074637.4	SRY (sex determining region Y)-box 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Sox2	mm10_v2_chr3_+_34649987_34650005	0.40	1.7e-02	Click!

Activity profile of Sox2 motif

Sorted Z-values of Sox2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_-_134915512 Show fit	25.47	ENSMUST00000008987.4	Cldn13 Ensembl NCBI MGI UniProt Show fit	claudin 13
chr10_+_43579161 Show fit	23.12	ENSMUST00000058714.8	Cd24a Ensembl NCBI MGI UniProt Show fit	CD24a antigen
chr7_+_45216671 Show fit	21.50	ENSMUST00000134420.1	Tead2 Ensembl NCBI MGI UniProt Show fit	TEA domain family member 2
chr4_+_115057683 Show fit	21.44	ENSMUST00000161601.1	Tal1 Ensembl NCBI MGI UniProt Show fit	T cell acute lymphocytic leukemia 1
chr7_-_142661305 Show fit	18.19	ENSMUST00000105936.1	Igf2 Ensembl NCBI MGI UniProt Show fit	insulin-like growth factor 2
chr11_+_116531097 Show fit	15.02	ENSMUST00000138840.1	Sphk1 Ensembl NCBI MGI UniProt Show fit	sphingosine kinase 1
chr16_-_36367623 Show fit	13.41	ENSMUST00000096089.2	BC100530 Ensembl NCBI MGI UniProt Show fit	cDNA sequence BC100530
chr16_-_17125106 Show fit	12.91	ENSMUST00000093336.6	2610318N02Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 2610318N02 gene
chr3_-_98859774 Show fit	12.51	ENSMUST00000107016.3 ENSMUST00000149768.1	Hsd3b1 Ensembl NCBI MGI UniProt Show fit	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
chr3_-_98859753 Show fit	11.87	ENSMUST00000029465.6	Hsd3b1 Ensembl NCBI MGI UniProt Show fit	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.7	32.0	GO:0060217	hemangioblast cell differentiation(GO:0060217)
1.1	30.3	GO:0048368	lateral mesoderm development(GO:0048368)
7.7	23.1	GO:0002842	positive regulation of T cell mediated immune response to tumor cell(GO:0002842)
0.4	21.0	GO:0050853	B cell receptor signaling pathway(GO:0050853)
1.1	18.4	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
2.3	18.2	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
1.8	18.1	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
1.4	17.1	GO:0034242	negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
2.0	16.1	GO:0015671	oxygen transport(GO:0015671)
1.3	16.1	GO:0021778	oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)

Showing 1 to 10 of 397 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	35.9	GO:0005923	bicellular tight junction(GO:0005923)
10.7	32.0	GO:0033193	Lsd1/2 complex(GO:0033193)
9.8	29.5	GO:0071149	TEAD-2-YAP complex(GO:0071149)
1.2	26.5	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.1	24.0	GO:0031965	nuclear membrane(GO:0031965)
0.1	21.1	GO:0005667	transcription factor complex(GO:0005667)
1.1	18.8	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.2	17.2	GO:0016363	nuclear matrix(GO:0016363)
1.1	16.9	GO:0042555	MCM complex(GO:0042555)
0.1	16.5	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)

Showing 1 to 10 of 181 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	36.8	GO:0070888	E-box binding(GO:0070888)
1.7	33.7	GO:0001134	transcription factor activity, transcription factor recruiting(GO:0001134)
3.0	24.4	GO:0004769	steroid delta-isomerase activity(GO:0004769)
1.3	21.2	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.6	19.8	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
1.5	19.7	GO:0005522	profilin binding(GO:0005522)
0.1	19.7	GO:0003779	actin binding(GO:0003779)
0.5	17.4	GO:0008187	poly-pyrimidine tract binding(GO:0008187)
2.8	16.9	GO:0017077	oxidative phosphorylation uncoupler activity(GO:0017077)
0.5	16.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)

Showing 1 to 10 of 281 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	30.7	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.3	23.0	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.4	21.9	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.2	21.0	PID NOTCH PATHWAY	Notch signaling pathway
0.4	17.3	PID ATR PATHWAY	ATR signaling pathway
0.6	15.4	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.3	14.5	PID PLK1 PATHWAY	PLK1 signaling events
0.2	12.4	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.2	11.3	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.3	10.0	PID EPHB FWD PATHWAY	EPHB forward signaling

Showing 1 to 10 of 80 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	28.2	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.3	25.1	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.6	24.5	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
1.9	24.4	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
1.2	19.7	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.6	19.7	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.9	18.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4	17.5	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.4	16.7	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
1.0	16.6	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines

Showing 1 to 10 of 99 entries

Results for Sox2

Z-value: 3.20

Motif logo

Transcription factors associated with Sox2

Activity-expression correlation:

Activity profile of Sox2 motif

Sorted Z-values of Sox2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: