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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Runx1
Z-value: 1.98
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Transcription factors associated with Runx1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Runx1 | mm10_v2_chr16_-_92826004_92826080 | 0.87 | 5.0e-12 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_87793470 Show fit | 15.27 |
ENSMUST00000020779.4
|
myeloperoxidase |
|
| chr11_+_87793722 Show fit | 14.45 |
ENSMUST00000143021.2
|
myeloperoxidase |
|
| chr16_-_92826004 Show fit | 13.22 |
ENSMUST00000023673.7
|
runt related transcription factor 1 |
|
| chr2_-_28084877 Show fit | 10.65 |
ENSMUST00000028179.8
ENSMUST00000117486.1 ENSMUST00000135472.1 |
ficolin B |
|
| chr4_-_46404224 Show fit | 10.13 |
ENSMUST00000107764.2
|
hemogen |
|
| chr15_-_103255433 Show fit | 8.50 |
ENSMUST00000075192.6
|
nuclear factor, erythroid derived 2 |
|
| chr3_-_59101810 Show fit | 7.26 |
ENSMUST00000085040.4
|
G protein-coupled receptor 171 |
|
| chr1_+_40515362 Show fit | 6.96 |
ENSMUST00000027237.5
|
interleukin 18 receptor accessory protein |
|
| chr5_-_107726017 Show fit | 6.87 |
ENSMUST00000159263.2
|
growth factor independent 1 |
|
| chr2_+_164948219 Show fit | 6.76 |
ENSMUST00000017881.2
|
matrix metallopeptidase 9 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Runx1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.9 | 29.7 | GO:0002149 | hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149) |
| 4.4 | 13.2 | GO:2000872 | positive regulation of progesterone secretion(GO:2000872) |
| 2.7 | 10.6 | GO:0002752 | cell surface pattern recognition receptor signaling pathway(GO:0002752) |
| 0.1 | 9.1 | GO:0045667 | regulation of osteoblast differentiation(GO:0045667) |
| 0.7 | 8.5 | GO:0034242 | negative regulation of syncytium formation by plasma membrane fusion(GO:0034242) |
| 1.5 | 7.7 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
| 1.4 | 6.9 | GO:0070103 | negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) regulation of interleukin-6-mediated signaling pathway(GO:0070103) |
| 2.3 | 6.8 | GO:0071460 | cellular response to cell-matrix adhesion(GO:0071460) |
| 0.7 | 6.4 | GO:0032074 | negative regulation of nuclease activity(GO:0032074) |
| 0.6 | 6.0 | GO:0030886 | negative regulation of myeloid dendritic cell activation(GO:0030886) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 29.7 | GO:0005766 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.1 | 13.2 | GO:0005604 | basement membrane(GO:0005604) |
| 0.8 | 10.6 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.0 | 8.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 6.9 | GO:0016363 | nuclear matrix(GO:0016363) |
| 1.5 | 6.0 | GO:0070442 | integrin alphaIIb-beta3 complex(GO:0070442) |
| 0.4 | 5.8 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.0 | 5.7 | GO:0005884 | actin filament(GO:0005884) |
| 0.5 | 5.6 | GO:0097208 | alveolar lamellar body(GO:0097208) |
| 0.0 | 5.1 | GO:0000790 | nuclear chromatin(GO:0000790) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 29.7 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.3 | 13.2 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 1.2 | 10.6 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.0 | 8.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 8.7 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.5 | 7.3 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.6 | 7.0 | GO:0004908 | interleukin-1 receptor activity(GO:0004908) |
| 0.0 | 6.1 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.2 | 5.7 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.2 | 5.6 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 34.0 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.3 | 16.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.3 | 14.7 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 7.3 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.2 | 6.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 6.4 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 6.0 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.5 | 5.9 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 5.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 4.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.5 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.2 | 5.8 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.2 | 5.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.3 | 5.2 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 4.7 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.2 | 4.6 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 3.6 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 3.3 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 3.3 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.1 | 3.2 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |