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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Runx1

Z-value: 1.98

Motif logo

Transcription factors associated with Runx1

Gene Symbol Gene ID Gene Info
ENSMUSG00000022952.10 runt related transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Runx1mm10_v2_chr16_-_92826004_928260800.875.0e-12Click!

Activity profile of Runx1 motif

Sorted Z-values of Runx1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_87793470 15.27 ENSMUST00000020779.4
myeloperoxidase
chr11_+_87793722 14.45 ENSMUST00000143021.2
myeloperoxidase
chr16_-_92826004 13.22 ENSMUST00000023673.7
runt related transcription factor 1
chr2_-_28084877 10.65 ENSMUST00000028179.8
ENSMUST00000117486.1
ENSMUST00000135472.1
ficolin B
chr4_-_46404224 10.13 ENSMUST00000107764.2
hemogen
chr15_-_103255433 8.50 ENSMUST00000075192.6
nuclear factor, erythroid derived 2
chr3_-_59101810 7.26 ENSMUST00000085040.4
G protein-coupled receptor 171
chr1_+_40515362 6.96 ENSMUST00000027237.5
interleukin 18 receptor accessory protein
chr5_-_107726017 6.87 ENSMUST00000159263.2
growth factor independent 1
chr2_+_164948219 6.76 ENSMUST00000017881.2
matrix metallopeptidase 9
chr13_-_113100971 6.43 ENSMUST00000023897.5
granzyme A
chr7_+_143005046 6.02 ENSMUST00000009396.6
tetraspanin 32
chr7_-_127137807 5.84 ENSMUST00000049931.5
sialophorin
chr14_+_56042123 5.78 ENSMUST00000015576.4
mast cell protease 2
chr7_+_44572370 5.63 ENSMUST00000002274.8
napsin A aspartic peptidase
chr7_+_24370255 5.49 ENSMUST00000171904.1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr13_+_76579670 5.31 ENSMUST00000126960.1
ENSMUST00000109583.2
multiple C2 domains, transmembrane 1
chr15_-_66801577 5.25 ENSMUST00000168589.1
src-like adaptor
chr2_+_172393900 5.10 ENSMUST00000109136.2
Cas scaffolding protein family member 4
chr17_+_31208049 5.00 ENSMUST00000173776.1
ubiquitin associated and SH3 domain containing, A
chrX_-_8090442 4.34 ENSMUST00000033505.6
Wiskott-Aldrich syndrome homolog (human)
chr18_-_35649349 4.32 ENSMUST00000025211.4
marginal zone B and B1 cell-specific protein 1
chr2_-_58160495 4.29 ENSMUST00000028175.6
cytohesin 1 interacting protein
chr4_+_135120640 3.89 ENSMUST00000056977.7
runt related transcription factor 3
chr3_+_103860265 3.89 ENSMUST00000029433.7
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr8_+_105690906 3.79 ENSMUST00000062574.6
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr17_+_47596061 3.62 ENSMUST00000182539.1
cyclin D3
chr17_+_12119274 3.25 ENSMUST00000024594.2
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr7_-_43533171 3.19 ENSMUST00000004728.5
ENSMUST00000039861.5
CD33 antigen
chr2_-_26021679 3.07 ENSMUST00000036509.7
ubiquitin associated domain containing 1
chr11_-_83649349 3.03 ENSMUST00000001008.5
chemokine (C-C motif) ligand 3
chrX_-_57338598 3.01 ENSMUST00000033468.4
ENSMUST00000114736.1
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr4_-_133872997 2.97 ENSMUST00000137486.2
ribosomal protein S6 kinase polypeptide 1
chr2_-_26021532 2.96 ENSMUST00000136750.1
ubiquitin associated domain containing 1
chr12_+_85686648 2.95 ENSMUST00000040536.5
basic leucine zipper transcription factor, ATF-like
chr14_-_56262233 2.87 ENSMUST00000015581.4
granzyme B
chr7_-_25132473 2.84 ENSMUST00000108418.4
ENSMUST00000108415.3
ENSMUST00000098679.3
ENSMUST00000175774.2
ENSMUST00000108417.3
ENSMUST00000108416.3
ENSMUST00000108414.1
ENSMUST00000108413.1
ENSMUST00000176408.1
POU domain, class 2, transcription factor 2
chr11_+_69966896 2.69 ENSMUST00000151515.1
claudin 7
chr8_-_11008458 2.67 ENSMUST00000040514.6
insulin receptor substrate 2
chr3_+_96181151 2.54 ENSMUST00000035371.8
synaptic vesicle glycoprotein 2 a
chr17_+_33638056 2.48 ENSMUST00000052079.7
PML-RAR alpha-regulated adaptor molecule 1
chr13_+_76579681 2.41 ENSMUST00000109589.2
multiple C2 domains, transmembrane 1
chr6_-_136941494 2.38 ENSMUST00000111892.1
Rho, GDP dissociation inhibitor (GDI) beta
chr15_-_9529868 2.38 ENSMUST00000003981.4
interleukin 7 receptor
chr11_-_79530569 2.35 ENSMUST00000103236.3
ENSMUST00000170799.1
ENSMUST00000170422.2
ecotropic viral integration site 2a
ecotropic viral integration site 2b
chrX_+_159697308 2.34 ENSMUST00000123433.1
SH3-domain kinase binding protein 1
chr14_+_70774304 2.25 ENSMUST00000022698.7
docking protein 2
chr18_-_62179948 2.23 ENSMUST00000053640.3
adrenergic receptor, beta 2
chr6_-_136941694 2.23 ENSMUST00000032344.5
Rho, GDP dissociation inhibitor (GDI) beta
chr2_+_153938218 2.23 ENSMUST00000109757.1
BPI fold containing family B, member 4
chr15_-_34356421 2.19 ENSMUST00000179647.1
RIKEN cDNA 9430069I07 gene
chr11_-_69895523 2.10 ENSMUST00000001631.6
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr2_-_119760295 2.08 ENSMUST00000082130.6
ENSMUST00000028759.6
leukocyte tyrosine kinase
chr15_-_98607611 2.06 ENSMUST00000096224.4
adenylate cyclase 6
chr10_+_118441044 2.05 ENSMUST00000068592.3
interferon gamma
chr2_-_73485733 2.00 ENSMUST00000102680.1
WAS/WASL interacting protein family, member 1
chr11_-_4594750 1.96 ENSMUST00000109943.3
myotubularin related protein 3
chr7_-_133709051 1.94 ENSMUST00000124759.1
ENSMUST00000106144.1
uroporphyrinogen III synthase
chr7_-_115824699 1.94 ENSMUST00000169129.1
SRY-box containing gene 6
chr16_-_58718724 1.86 ENSMUST00000089318.3
G protein-coupled receptor 15
chr4_-_129573637 1.81 ENSMUST00000102596.1
lymphocyte protein tyrosine kinase
chr4_-_70410422 1.78 ENSMUST00000144099.1
CDK5 regulatory subunit associated protein 2
chr2_-_73486456 1.72 ENSMUST00000141264.1
WAS/WASL interacting protein family, member 1
chr7_-_25675047 1.69 ENSMUST00000108404.1
ENSMUST00000108405.1
ENSMUST00000079439.3
transmembrane protein 91
chr18_+_62180119 1.68 ENSMUST00000067743.1
predicted gene 9949
chr15_+_9436028 1.58 ENSMUST00000042360.3
calcyphosine-like
chr11_-_101095367 1.54 ENSMUST00000019447.8
proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein
chr12_-_112860886 1.51 ENSMUST00000021729.7
G protein-coupled receptor 132
chr5_+_139406387 1.48 ENSMUST00000052176.8
RIKEN cDNA C130050O18 gene
chr17_+_75178797 1.48 ENSMUST00000112516.1
ENSMUST00000135447.1
latent transforming growth factor beta binding protein 1
chr3_-_96814518 1.46 ENSMUST00000047702.7
CD160 antigen
chr15_-_97844254 1.44 ENSMUST00000119670.1
ENSMUST00000116409.2
histone deacetylase 7
chr15_-_97844164 1.43 ENSMUST00000120683.1
histone deacetylase 7
chr7_-_133708958 1.38 ENSMUST00000106146.1
uroporphyrinogen III synthase
chr7_+_126584937 1.34 ENSMUST00000039522.6
apolipoprotein B receptor
chr17_+_75178911 1.29 ENSMUST00000112514.1
latent transforming growth factor beta binding protein 1
chr10_-_40302186 1.28 ENSMUST00000099945.4
S-adenosylmethionine decarboxylase 1
chr1_+_171388954 1.28 ENSMUST00000056449.8
Rho GTPase activating protein 30
chr7_-_133709069 1.27 ENSMUST00000106145.3
uroporphyrinogen III synthase
chr8_+_109705549 1.27 ENSMUST00000034163.8
zinc finger protein 821
chr2_-_32741016 1.24 ENSMUST00000009695.2
RIKEN cDNA 6330409D20 gene
chr2_+_153918391 1.24 ENSMUST00000109760.1
BPI fold containing family B, member 3
chr5_+_140607334 1.23 ENSMUST00000031555.1
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chrX_-_48034842 1.23 ENSMUST00000039026.7
apelin
chr8_+_94667082 1.20 ENSMUST00000109527.4
ADP-ribosylation factor-like 2 binding protein
chr1_-_138175126 1.17 ENSMUST00000183301.1
protein tyrosine phosphatase, receptor type, C
chr19_+_5568002 1.16 ENSMUST00000096318.3
adaptor-related protein complex 5, beta 1 subunit
chr1_-_138175283 1.14 ENSMUST00000182755.1
ENSMUST00000183262.1
ENSMUST00000027645.7
ENSMUST00000112036.2
ENSMUST00000182283.1
protein tyrosine phosphatase, receptor type, C
chr5_+_48242549 1.12 ENSMUST00000172493.1
slit homolog 2 (Drosophila)
chr9_-_32928928 1.11 ENSMUST00000185169.1
RP24-308I2.1
chrX_+_56786527 1.10 ENSMUST00000144600.1
four and a half LIM domains 1
chr1_-_138175238 1.09 ENSMUST00000182536.1
protein tyrosine phosphatase, receptor type, C
chr4_-_41275091 1.09 ENSMUST00000030143.6
ENSMUST00000108068.1
ubiquitin-associated protein 2
chr2_+_172393794 1.07 ENSMUST00000099061.2
ENSMUST00000103073.2
Cas scaffolding protein family member 4
chr3_-_86142684 1.04 ENSMUST00000029722.6
ribosomal protein S3A1
chr15_+_80711292 1.01 ENSMUST00000067689.7
trinucleotide repeat containing 6b
chr16_-_95586585 0.93 ENSMUST00000077773.6
avian erythroblastosis virus E-26 (v-ets) oncogene related
chr16_+_18877037 0.91 ENSMUST00000120532.1
ENSMUST00000004222.7
histone cell cycle regulation defective homolog A (S. cerevisiae)
chr11_-_110168073 0.87 ENSMUST00000044850.3
ATP-binding cassette, sub-family A (ABC1), member 9
chr10_-_95673451 0.87 ENSMUST00000099328.1
anaphase prompoting complex C subunit 15, pseudogene
chr9_-_107770945 0.85 ENSMUST00000183248.1
ENSMUST00000182022.1
ENSMUST00000035199.6
ENSMUST00000182659.1
RNA binding motif protein 5
chr11_-_100121558 0.83 ENSMUST00000007275.2
keratin 13
chr15_-_78493607 0.83 ENSMUST00000163494.1
interleukin 2 receptor, beta chain
chr4_-_6990774 0.83 ENSMUST00000039987.3
thymocyte selection-associated high mobility group box
chr1_-_161788489 0.82 ENSMUST00000000834.2
Fas ligand (TNF superfamily, member 6)
chr6_+_136518820 0.82 ENSMUST00000032335.6
activating transcription factor 7 interacting protein
chr4_+_133176336 0.75 ENSMUST00000105912.1
WAS protein family, member 2
chr1_+_160044564 0.72 ENSMUST00000168359.1
RIKEN cDNA 4930523C07 gene
chr4_-_152038568 0.71 ENSMUST00000030792.1
taste receptor, type 1, member 1
chrX_-_12160355 0.67 ENSMUST00000043441.6
BCL6 interacting corepressor
chr1_-_164935522 0.59 ENSMUST00000027860.7
chemokine (C motif) ligand 1
chr16_+_32271468 0.57 ENSMUST00000093183.3
single-pass membrane protein with coiled-coil domains 1
chr6_-_38637220 0.55 ENSMUST00000096030.3
killer cell lectin-like receptor subfamily G, member 2
chr10_-_127288999 0.54 ENSMUST00000119078.1
methyl-CpG binding domain protein 6
chr14_-_121915774 0.51 ENSMUST00000055475.7
G protein-coupled receptor 18
chr1_+_172956768 0.48 ENSMUST00000038432.4
olfactory receptor 16
chr9_+_113812547 0.45 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
CLIP associating protein 2
chr7_-_132852606 0.45 ENSMUST00000120425.1
methyltransferase like 10
chr9_+_108479849 0.41 ENSMUST00000065014.4
laminin, beta 2
chr12_+_116077720 0.41 ENSMUST00000011315.3
vasoactive intestinal peptide receptor 2
chr5_+_87808082 0.41 ENSMUST00000072539.5
ENSMUST00000113279.1
ENSMUST00000101057.3
casein alpha s2-like B
chr10_-_127288851 0.40 ENSMUST00000156208.1
ENSMUST00000026476.6
methyl-CpG binding domain protein 6
chr2_-_20943413 0.40 ENSMUST00000140230.1
Rho GTPase activating protein 21
chr1_+_36307727 0.34 ENSMUST00000126413.1
AT rich interactive domain 5A (MRF1-like)
chr2_+_37516618 0.33 ENSMUST00000065441.6
G protein-coupled receptor 21
chr11_+_75531690 0.30 ENSMUST00000149727.1
ENSMUST00000042561.7
ENSMUST00000108433.1
ENSMUST00000143035.1
solute carrier family 43, member 2
chrX_-_20950597 0.29 ENSMUST00000009550.7
ELK1, member of ETS oncogene family
chr9_-_66514567 0.28 ENSMUST00000056890.8
F-box and leucine-rich repeat protein 22
chr19_+_4214238 0.26 ENSMUST00000046506.6
cardiotrophin-like cytokine factor 1
chr12_-_34528844 0.26 ENSMUST00000110819.2
histone deacetylase 9
chr14_+_56017964 0.24 ENSMUST00000022836.4
mast cell protease 1
chr10_-_14718191 0.22 ENSMUST00000020016.4
gap junction protein, epsilon 1
chr15_+_62037986 0.22 ENSMUST00000182956.1
ENSMUST00000182075.1
ENSMUST00000180432.2
ENSMUST00000181416.2
ENSMUST00000181657.2
plasmacytoma variant translocation 1
chr2_+_86041317 0.21 ENSMUST00000111589.1
olfactory receptor 1033
chr2_-_71367749 0.20 ENSMUST00000151937.1
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr3_-_88378699 0.19 ENSMUST00000098956.2
bone gamma-carboxyglutamate protein 2
chr1_-_174118014 0.18 ENSMUST00000063030.3
olfactory receptor 231
chr16_+_91391721 0.18 ENSMUST00000160764.1
predicted gene 21970
chr11_+_77686155 0.18 ENSMUST00000100802.4
ENSMUST00000181023.1
nuclear fragile X mental retardation protein interacting protein 2
chr17_-_44814649 0.18 ENSMUST00000113571.3
runt related transcription factor 2
chr16_+_25801907 0.16 ENSMUST00000040231.6
ENSMUST00000115306.1
ENSMUST00000115304.1
ENSMUST00000115305.1
transformation related protein 63
chr11_+_75532127 0.15 ENSMUST00000127226.1
solute carrier family 43, member 2
chr19_-_8839181 0.15 ENSMUST00000096259.4
guanine nucleotide binding protein (G protein), gamma 3
chr17_-_44814604 0.15 ENSMUST00000160673.1
runt related transcription factor 2
chr16_-_38433145 0.15 ENSMUST00000002926.6
phospholipase A1 member A
chr1_+_60746358 0.14 ENSMUST00000027165.2
CD28 antigen
chr2_+_35691893 0.13 ENSMUST00000065001.5
disabled 2 interacting protein
chr15_+_62178175 0.11 ENSMUST00000182476.1
plasmacytoma variant translocation 1
chr1_+_36307745 0.10 ENSMUST00000142319.1
ENSMUST00000097778.2
ENSMUST00000115031.1
ENSMUST00000115032.1
ENSMUST00000137906.1
ENSMUST00000115029.1
AT rich interactive domain 5A (MRF1-like)
chr6_-_83070225 0.08 ENSMUST00000174674.1
ENSMUST00000089641.3
T cell leukemia, homeobox 2
chr12_+_95692212 0.08 ENSMUST00000057324.3
fibronectin leucine rich transmembrane protein 2
chr3_-_107760221 0.08 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
colony stimulating factor 1 (macrophage)
chr14_-_20618339 0.08 ENSMUST00000035340.7
ubiquitin specific peptidase 54
chr7_-_132852657 0.07 ENSMUST00000033257.8
methyltransferase like 10
chr19_+_5050807 0.06 ENSMUST00000025818.6
Ras and Rab interactor 1
chr4_+_102991784 0.06 ENSMUST00000140654.1
ENSMUST00000169211.1
Tctex1 domain containing 1
chr15_-_38519227 0.05 ENSMUST00000110328.1
ENSMUST00000110329.1
ENSMUST00000065308.5
antizyme inhibitor 1
chrX_-_50942710 0.05 ENSMUST00000060650.5
FERM domain containing 7
chr4_+_65124174 0.05 ENSMUST00000084501.3
pregnancy-associated plasma protein A
chr18_+_37411674 0.04 ENSMUST00000051126.2
protocadherin beta 10
chr11_-_72215592 0.04 ENSMUST00000021157.8
mediator of RNA polymerase II transcription, subunit 31 homolog (yeast)
chr2_+_32629467 0.04 ENSMUST00000068271.4
adenylate kinase 1
chr15_-_102722120 0.03 ENSMUST00000171838.1
calcium binding and coiled coil domain 1
chr11_-_102218923 0.02 ENSMUST00000131254.1
histone deacetylase 5
chr17_-_36958533 0.02 ENSMUST00000172518.1
zinc ribbon domain containing, 1
chr15_-_102722150 0.02 ENSMUST00000023818.3
calcium binding and coiled coil domain 1
chr3_+_103058302 0.01 ENSMUST00000029445.6
neuroblastoma ras oncogene
chr11_-_52282564 0.00 ENSMUST00000086844.3
transcription factor 7, T cell specific

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.9 29.7 GO:0002149 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
4.4 13.2 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
2.7 10.6 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
2.3 6.8 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
1.9 5.8 GO:0002865 regulation of type IV hypersensitivity(GO:0001807) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) negative regulation of hypersensitivity(GO:0002884)
1.5 7.7 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
1.5 4.5 GO:0071663 granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
1.4 6.9 GO:0070103 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) regulation of interleukin-6-mediated signaling pathway(GO:0070103)
1.1 4.6 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780)
0.7 4.3 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.7 6.4 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.7 8.5 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.7 2.0 GO:0060559 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.6 6.0 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.6 4.6 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.6 2.9 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.6 2.2 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.5 1.5 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.5 2.4 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.4 1.3 GO:0006597 spermine biosynthetic process(GO:0006597)
0.4 5.5 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.4 1.1 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.3 2.1 GO:0035811 negative regulation of urine volume(GO:0035811)
0.3 3.0 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.3 1.8 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.3 3.0 GO:0043615 astrocyte cell migration(GO:0043615)
0.2 5.0 GO:0038065 collagen-activated signaling pathway(GO:0038065)
0.2 2.5 GO:0043313 regulation of neutrophil degranulation(GO:0043313)
0.2 1.2 GO:0007386 compartment pattern specification(GO:0007386)
0.2 2.7 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.2 0.4 GO:2000554 regulation of T-helper 1 cell cytokine production(GO:2000554) positive regulation of T-helper 1 cell cytokine production(GO:2000556)
0.2 3.1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.2 0.4 GO:0072244 metanephric glomerular epithelium development(GO:0072244)
0.2 3.6 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.2 3.0 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.2 2.5 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.2 1.8 GO:0045588 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645)
0.2 1.9 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 0.5 GO:0002304 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.2 0.7 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.2 0.8 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.2 0.2 GO:0060197 cloacal septation(GO:0060197)
0.2 2.1 GO:0043129 surfactant homeostasis(GO:0043129)
0.2 0.9 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.1 3.9 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.1 2.7 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.1 0.7 GO:0050917 sensory perception of umami taste(GO:0050917)
0.1 3.7 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.1 2.8 GO:0048305 immunoglobulin secretion(GO:0048305)
0.1 2.8 GO:0010714 positive regulation of collagen metabolic process(GO:0010714) positive regulation of collagen biosynthetic process(GO:0032967) positive regulation of multicellular organismal metabolic process(GO:0044253)
0.1 1.0 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 0.4 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.4 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 2.0 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 2.6 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.1 9.1 GO:0045667 regulation of osteoblast differentiation(GO:0045667)
0.1 5.4 GO:0045638 negative regulation of myeloid cell differentiation(GO:0045638)
0.1 0.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 1.2 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.9 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.8 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 2.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.1 GO:1903972 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.0 0.8 GO:0035855 megakaryocyte development(GO:0035855)
0.0 1.5 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.1 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.0 0.4 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.0 1.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 1.5 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 1.4 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0046641 positive regulation of alpha-beta T cell proliferation(GO:0046641)
0.0 3.3 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 0.0 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 2.3 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.7 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 29.7 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
1.5 6.0 GO:0070442 integrin alphaIIb-beta3 complex(GO:0070442)
0.9 2.8 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.8 10.6 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.7 2.9 GO:0044194 cytolytic granule(GO:0044194)
0.5 5.6 GO:0097208 alveolar lamellar body(GO:0097208)
0.4 5.8 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.3 4.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 3.6 GO:0000242 pericentriolar material(GO:0000242)
0.1 0.4 GO:0005608 laminin-3 complex(GO:0005608)
0.1 0.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 13.2 GO:0005604 basement membrane(GO:0005604)
0.1 2.1 GO:0031528 microvillus membrane(GO:0031528)
0.1 1.3 GO:0034362 low-density lipoprotein particle(GO:0034362) chylomicron(GO:0042627)
0.1 0.3 GO:0097059 CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059)
0.1 1.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.8 GO:0031209 SCAR complex(GO:0031209)
0.1 6.9 GO:0016363 nuclear matrix(GO:0016363)
0.1 2.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 2.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 8.0 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.9 GO:0010369 chromocenter(GO:0010369)
0.0 3.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 5.7 GO:0005884 actin filament(GO:0005884)
0.0 0.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 1.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 4.3 GO:0005938 cell cortex(GO:0005938)
0.0 3.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.7 GO:0031519 PcG protein complex(GO:0031519)
0.0 4.6 GO:0005925 focal adhesion(GO:0005925)
0.0 1.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 2.5 GO:0030027 lamellipodium(GO:0030027)
0.0 5.1 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 3.2 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 4.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 3.0 GO:0005819 spindle(GO:0005819)
0.0 2.0 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.5 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
1.2 10.6 GO:0033691 sialic acid binding(GO:0033691)
0.8 4.6 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.7 2.8 GO:0050436 microfibril binding(GO:0050436)
0.6 7.0 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.6 4.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.6 2.2 GO:0004939 beta-adrenergic receptor activity(GO:0004939) bradykinin receptor binding(GO:0031711)
0.5 7.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.5 29.7 GO:0004601 peroxidase activity(GO:0004601)
0.4 1.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.4 1.8 GO:0042610 CD8 receptor binding(GO:0042610)
0.3 2.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.3 13.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 0.8 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.2 2.0 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 1.3 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.2 5.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.2 1.3 GO:0019808 polyamine binding(GO:0019808)
0.2 8.7 GO:0050699 WW domain binding(GO:0050699)
0.2 2.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 3.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2 5.7 GO:0001968 fibronectin binding(GO:0001968)
0.1 3.2 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 1.1 GO:0043237 GTPase inhibitor activity(GO:0005095) laminin-1 binding(GO:0043237) Roundabout binding(GO:0048495)
0.1 0.4 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.1 3.2 GO:0043274 phospholipase binding(GO:0043274)
0.1 3.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 1.5 GO:0050692 DBD domain binding(GO:0050692)
0.1 3.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 2.8 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 0.3 GO:0004952 dopamine neurotransmitter receptor activity(GO:0004952)
0.1 0.7 GO:0008527 taste receptor activity(GO:0008527)
0.1 3.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 3.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 4.3 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.1 0.2 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.2 GO:0046848 hydroxyapatite binding(GO:0046848)
0.0 0.8 GO:0005123 death receptor binding(GO:0005123)
0.0 8.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0 1.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.5 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.3 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 6.1 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.2 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.0 2.3 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 2.1 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 3.7 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 1.0 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.4 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 2.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.9 GO:0031491 nucleosome binding(GO:0031491)
0.0 1.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 34.0 PID IL23 PATHWAY IL23-mediated signaling events
0.5 5.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3 16.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 14.7 PID IL12 2PATHWAY IL12-mediated signaling events
0.2 6.8 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 2.1 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 6.4 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 2.7 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.1 2.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 2.7 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 7.3 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 5.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.2 PID ARF6 PATHWAY Arf6 signaling events
0.1 4.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 1.1 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 3.8 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 2.3 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 6.0 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.1 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 4.0 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.0 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2 4.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 5.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 5.8 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 2.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 2.1 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 2.0 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.1 2.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.7 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.1 3.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 3.3 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 3.6 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 1.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 3.3 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 2.9 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 2.3 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 8.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.2 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 3.2 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 2.0 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.0 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.9 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.5 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 4.7 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 1.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.8 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.4 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 2.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.1 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events