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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Pou2f2_Pou3f1
Z-value: 1.45
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Transcription factors associated with Pou2f2_Pou3f1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pou3f1 | mm10_v2_chr4_+_124657646_124657656 | -0.29 | 9.1e-02 | Click! |
| Pou2f2 | mm10_v2_chr7_-_25132473_25132512 | 0.22 | 2.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_+_23746734 Show fit | 11.16 |
ENSMUST00000099703.2
|
histone cluster 1, H2bb |
|
| chr3_+_96269695 Show fit | 9.64 |
ENSMUST00000051089.3
ENSMUST00000177113.1 |
histone cluster 2, H2bb |
|
| chr13_+_21722057 Show fit | 8.82 |
ENSMUST00000110476.3
|
histone cluster 1, H2bm |
|
| chrX_+_93675088 Show fit | 6.71 |
ENSMUST00000045898.3
|
phosphate cytidylyltransferase 1, choline, beta isoform |
|
| chr11_+_58948890 Show fit | 6.42 |
ENSMUST00000078267.3
|
histone cluster 3, H2ba |
|
| chr10_-_80421847 Show fit | 5.57 |
ENSMUST00000156244.1
|
transcription factor 3 |
|
| chr7_-_102100227 Show fit | 5.55 |
ENSMUST00000106937.1
|
ADP-ribosyltransferase 5 |
|
| chr13_-_21833575 Show fit | 5.35 |
ENSMUST00000081342.5
|
histone cluster 1, H2ap |
|
| chr16_+_17144600 Show fit | 5.07 |
ENSMUST00000115702.1
|
YdjC homolog (bacterial) |
|
| chr7_+_24507006 Show fit | 5.05 |
ENSMUST00000176880.1
|
zinc finger protein 428 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Pou2f2_Pou3f1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 44.3 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.2 | 25.8 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.2 | 7.9 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.2 | 7.7 | GO:0006284 | base-excision repair(GO:0006284) |
| 0.2 | 6.2 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.7 | 5.6 | GO:0002326 | B cell lineage commitment(GO:0002326) |
| 0.1 | 5.5 | GO:0001541 | ovarian follicle development(GO:0001541) |
| 0.6 | 4.6 | GO:0021555 | midbrain-hindbrain boundary morphogenesis(GO:0021555) |
| 0.1 | 4.6 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.4 | 4.5 | GO:0030916 | otic vesicle formation(GO:0030916) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 47.6 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 21.9 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.4 | 8.4 | GO:0019814 | immunoglobulin complex(GO:0019814) |
| 0.9 | 7.7 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.0 | 6.4 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 3.9 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 3.7 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 3.6 | GO:0005604 | basement membrane(GO:0005604) |
| 0.4 | 3.5 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 3.3 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.6 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.1 | 9.7 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 2.0 | 7.9 | GO:0003953 | NAD+ nucleosidase activity(GO:0003953) |
| 0.8 | 7.7 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 1.3 | 6.7 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.2 | 6.2 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.7 | 5.6 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.1 | 5.1 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 4.9 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.9 | 3.8 | GO:0004464 | leukotriene-C4 synthase activity(GO:0004464) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 6.1 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 4.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 4.5 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 4.4 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 3.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 3.2 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 2.6 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 2.5 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 1.9 | NABA COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 43.9 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 1.0 | 7.7 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.2 | 6.7 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.2 | 5.4 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 4.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 3.8 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 3.7 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.2 | 3.3 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.1 | 3.3 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 3.3 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |