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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Pax4

Z-value: 0.46

Motif logo

Transcription factors associated with Pax4

Gene Symbol Gene ID Gene Info
ENSMUSG00000029706.9 paired box 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax4mm10_v2_chr6_-_28447180_284471800.048.3e-01Click!

Activity profile of Pax4 motif

Sorted Z-values of Pax4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_88033328 0.85 ENSMUST00000078090.5
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr7_+_78913765 0.61 ENSMUST00000038142.8
interferon-stimulated protein
chr7_+_78913436 0.58 ENSMUST00000121645.1
interferon-stimulated protein
chr12_+_33314277 0.56 ENSMUST00000133549.1
ataxin 7-like 1
chr13_+_21717626 0.56 ENSMUST00000091754.2
histone cluster 1, H3h
chr17_+_26941420 0.52 ENSMUST00000081285.3
ENSMUST00000177932.1
synaptic Ras GTPase activating protein 1 homolog (rat)
chr7_+_78913401 0.51 ENSMUST00000118867.1
interferon-stimulated protein
chr7_+_43440782 0.51 ENSMUST00000040227.1
claudin domain containing 2
chr19_+_55180716 0.50 ENSMUST00000154886.1
ENSMUST00000120936.1
tectorin beta
chr2_-_160313616 0.49 ENSMUST00000109475.2
predicted gene 826
chr12_+_33314375 0.49 ENSMUST00000155386.1
ataxin 7-like 1
chr13_+_109632760 0.47 ENSMUST00000135275.1
phosphodiesterase 4D, cAMP specific
chr2_-_114175274 0.45 ENSMUST00000102543.4
aquarius
chr19_-_6015152 0.43 ENSMUST00000025891.8
calpain 1
chr4_+_136357423 0.43 ENSMUST00000182167.1
predicted gene, 17388
chr17_-_23645264 0.42 ENSMUST00000024696.7
matrix metallopeptidase 25
chr19_-_6015769 0.40 ENSMUST00000164843.1
calpain 1
chr4_+_147132038 0.39 ENSMUST00000084149.3
predicted gene 13139
chr7_+_81114799 0.36 ENSMUST00000026820.4
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chr14_+_53704007 0.36 ENSMUST00000103664.4
T cell receptor alpha variable 5-4
chr12_-_84218835 0.35 ENSMUST00000046266.6
ELM2 and Myb/SANT-like domain containing 1
chr11_+_98907801 0.34 ENSMUST00000092706.6
cell division cycle 6
chrX_-_53209724 0.33 ENSMUST00000174390.1
placental specific protein 1
chrX_+_9199865 0.31 ENSMUST00000069763.2
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr10_+_119992916 0.31 ENSMUST00000105261.2
glutamate receptor interacting protein 1
chr19_+_3972322 0.28 ENSMUST00000143380.1
aldehyde dehydrogenase 3 family, member B2
chr12_+_71048338 0.27 ENSMUST00000135709.1
AT rich interactive domain 4A (RBP1-like)
chr15_-_79164477 0.26 ENSMUST00000040019.4
SRY-box containing gene 10
chr16_-_88774201 0.26 ENSMUST00000054223.2
RIKEN cDNA 2310057N15 gene
chr4_+_136284708 0.25 ENSMUST00000130223.1
zinc finger protein 46
chr11_+_62574523 0.25 ENSMUST00000018651.7
transient receptor potential cation channel, subfamily V, member 2
chr10_-_62792243 0.25 ENSMUST00000020268.5
cell division cycle and apoptosis regulator 1
chr5_+_66676098 0.25 ENSMUST00000031131.9
ubiquitin carboxy-terminal hydrolase L1
chr10_+_26822560 0.25 ENSMUST00000135866.1
Rho GTPase activating protein 18
chr8_+_8689666 0.25 ENSMUST00000179702.1
RIKEN cDNA B930078G14 gene
chr7_+_58658181 0.25 ENSMUST00000168747.1
ATPase, class V, type 10A
chr11_+_87127052 0.24 ENSMUST00000041282.6
tripartite motif-containing 37
chr8_-_4217261 0.23 ENSMUST00000168386.2
cDNA sequence BC068157
chrM_+_11734 0.22 ENSMUST00000082418.1
mitochondrially encoded NADH dehydrogenase 5
chr17_+_69383024 0.22 ENSMUST00000112674.1
zinc finger and BTB domain containing 14
chr17_+_17402672 0.21 ENSMUST00000115576.2
limb expression 1 homolog (chicken)
chr13_-_66851513 0.21 ENSMUST00000169322.1
predicted gene, 17404
chr17_+_35108279 0.21 ENSMUST00000037849.2
lymphocyte antigen 6 complex, locus G5C
chr16_-_36666067 0.20 ENSMUST00000089620.4
CD86 antigen
chr4_+_6365650 0.20 ENSMUST00000029912.4
ENSMUST00000103008.5
ENSMUST00000175769.1
ENSMUST00000108374.1
ENSMUST00000140830.1
syndecan binding protein
chr5_-_121502980 0.20 ENSMUST00000079368.3
a disintegrin and metallopeptidase domain 1b
chr16_-_13730970 0.20 ENSMUST00000023364.6
phospholipase A2, group X
chr4_-_58987095 0.19 ENSMUST00000030069.6
prostaglandin reductase 1
chr4_+_136284658 0.19 ENSMUST00000144217.1
zinc finger protein 46
chr6_+_48613180 0.19 ENSMUST00000061720.4
zinc finger protein 775
chr19_+_53140430 0.19 ENSMUST00000111741.2
adducin 3 (gamma)
chr2_+_22895583 0.18 ENSMUST00000152170.1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr19_-_10482874 0.18 ENSMUST00000038842.3
protein phosphatase 1, regulatory subunit 32
chr7_-_45366714 0.18 ENSMUST00000107779.1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr2_-_114654943 0.18 ENSMUST00000028640.7
ENSMUST00000102542.3
diphthamine biosynthesis 6
chr7_+_24862193 0.17 ENSMUST00000052897.4
ENSMUST00000170837.2
predicted pseudogene 9844
predicted pseudogene 9844
chr2_+_22895482 0.17 ENSMUST00000053729.7
prenyl (solanesyl) diphosphate synthase, subunit 1
chr5_+_124552845 0.17 ENSMUST00000071057.7
DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
chr10_-_95673451 0.17 ENSMUST00000099328.1
anaphase prompoting complex C subunit 15, pseudogene
chr16_-_13730443 0.16 ENSMUST00000115807.2
phospholipase A2, group X
chr9_-_101198999 0.16 ENSMUST00000066773.7
protein phosphatase 2, regulatory subunit B'', alpha
chr2_-_114654861 0.15 ENSMUST00000055144.7
diphthamine biosynthesis 6
chr17_+_35059035 0.15 ENSMUST00000007255.6
ENSMUST00000174493.1
dimethylarginine dimethylaminohydrolase 2
chr15_+_78597047 0.15 ENSMUST00000043069.5
cytohesin 4
chr2_-_33086366 0.15 ENSMUST00000049618.2
GTPase activating RANGAP domain-like 3
chr16_+_15637844 0.14 ENSMUST00000023352.8
protein kinase, DNA activated, catalytic polypeptide
chr8_-_70700070 0.14 ENSMUST00000116172.1
predicted gene 11175
chr7_-_104279732 0.14 ENSMUST00000051795.9
tripartite motif-containing 5
chr4_+_146610961 0.13 ENSMUST00000130825.1
predicted gene 13248
chr13_-_66852017 0.13 ENSMUST00000059329.6
predicted gene, 17449
chrX_+_73192222 0.12 ENSMUST00000101486.4
X-linked lymphocyte-regulated 3B
chr6_+_136518820 0.12 ENSMUST00000032335.6
activating transcription factor 7 interacting protein
chrX_-_48877711 0.12 ENSMUST00000114928.1
predicted gene 595
chr5_+_76951382 0.12 ENSMUST00000141687.1
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
chr3_+_20057802 0.11 ENSMUST00000002502.5
helicase-like transcription factor
chr4_+_156235999 0.11 ENSMUST00000179543.1
ENSMUST00000179886.1
nucleolar complex associated 2 homolog (S. cerevisiae)
chr1_-_65032738 0.11 ENSMUST00000162800.1
ENSMUST00000069142.5
aldo-keto reductase family 1, member C-like
chr16_-_14291355 0.10 ENSMUST00000090287.3
myosin, heavy polypeptide 11, smooth muscle
chr4_+_150281573 0.10 ENSMUST00000105682.2
arginine glutamic acid dipeptide (RE) repeats
chr10_+_127421208 0.10 ENSMUST00000168780.1
R3H domain containing 2
chr6_-_130337502 0.10 ENSMUST00000088017.4
ENSMUST00000111998.2
killer cell lectin-like receptor, subfamily A, member 3
chr11_+_43587040 0.10 ENSMUST00000056256.2
RIKEN cDNA 4933415A04 gene
chr13_+_38204928 0.07 ENSMUST00000091641.5
ENSMUST00000178564.1
small nuclear ribonucleoprotein 48 (U11/U12)
chr4_+_125066672 0.07 ENSMUST00000052183.6
Smad nuclear interacting protein 1
chrX_-_9662950 0.07 ENSMUST00000033519.2
dynein light chain Tctex-type 3
chr13_-_55528511 0.07 ENSMUST00000047877.4
docking protein 3
chr15_-_88978958 0.07 ENSMUST00000042594.6
ENSMUST00000109368.1
megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)
chrX_-_155128409 0.06 ENSMUST00000076671.3
RIKEN cDNA 1700042B14 gene
chr12_-_90738438 0.06 ENSMUST00000082432.3
deiodinase, iodothyronine, type II
chr10_+_90071095 0.06 ENSMUST00000183109.1
ankyrin repeat and sterile alpha motif domain containing 1B
chr2_-_125506385 0.06 ENSMUST00000028633.6
fibrillin 1
chr4_+_155831272 0.05 ENSMUST00000139651.1
ENSMUST00000084097.5
aurora kinase A interacting protein 1
chr13_-_101768154 0.05 ENSMUST00000055518.6
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr5_-_116288944 0.05 ENSMUST00000086483.3
coiled-coil domain containing 60
chr16_-_45844228 0.05 ENSMUST00000076333.5
pleckstrin homology-like domain, family B, member 2
chr3_+_95624971 0.05 ENSMUST00000058230.6
ENSMUST00000037983.4
endosulfine alpha
chr10_-_64090241 0.04 ENSMUST00000133588.1
leucine rich repeat transmembrane neuronal 3
chr14_-_56159579 0.04 ENSMUST00000015578.4
granzyme G
chr11_+_117484368 0.04 ENSMUST00000092394.3
predicted gene 11733
chr6_+_65590382 0.03 ENSMUST00000114236.1
TNFAIP3 interacting protein 3
chr1_-_4360256 0.03 ENSMUST00000027032.4
retinitis pigmentosa 1 (human)
chr2_-_105904484 0.03 ENSMUST00000122965.1
elongation protein 4 homolog (S. cerevisiae)
chr9_+_36832684 0.02 ENSMUST00000034630.8
fasciculation and elongation protein zeta 1 (zygin I)
chr15_-_59374149 0.02 ENSMUST00000022976.4
RIKEN cDNA E430025E21 gene
chr9_+_32696005 0.02 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
E26 avian leukemia oncogene 1, 5' domain
chr14_-_12823031 0.02 ENSMUST00000067491.6
ENSMUST00000177814.1
ENSMUST00000112658.1
ENSMUST00000112657.2
Ca2+-dependent secretion activator
chrX_+_142227923 0.02 ENSMUST00000042329.5
nuclear transport factor 2-like export factor 2
chr15_-_50890041 0.02 ENSMUST00000077935.5
trichorhinophalangeal syndrome I (human)
chr16_-_45844303 0.02 ENSMUST00000036355.6
pleckstrin homology-like domain, family B, member 2
chr1_-_74935549 0.01 ENSMUST00000094844.3
coiled-coil domain containing 108
chr15_-_50889691 0.01 ENSMUST00000165201.2
ENSMUST00000184458.1
trichorhinophalangeal syndrome I (human)
chr6_+_67115671 0.01 ENSMUST00000181304.1
RIKEN cDNA A430010J10 gene
chr5_+_76951307 0.00 ENSMUST00000031160.9
ENSMUST00000120912.1
ENSMUST00000117536.1
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.4 GO:0051977 lysophospholipid transport(GO:0051977)
0.1 0.4 GO:0015851 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.1 0.2 GO:0002644 negative regulation of tolerance induction(GO:0002644)
0.1 0.8 GO:0097264 self proteolysis(GO:0097264)
0.1 0.3 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.1 0.9 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.4 GO:0060022 hard palate development(GO:0060022)
0.0 0.2 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 0.3 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.3 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.0 0.2 GO:0007412 axon target recognition(GO:0007412)
0.0 0.2 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.0 0.2 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.5 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 0.1 GO:0002326 B cell lineage commitment(GO:0002326) somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.0 0.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.3 GO:0051984 positive regulation of chromosome segregation(GO:0051984)
0.0 0.1 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
0.0 0.1 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.0 0.1 GO:0006527 arginine catabolic process(GO:0006527)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.0 1.7 GO:0015030 Cajal body(GO:0015030)
0.0 0.5 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.2 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.3 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.1 GO:1990462 omegasome(GO:1990462)
0.0 0.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.3 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0008859 exoribonuclease II activity(GO:0008859)
0.1 0.4 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.1 0.4 GO:0000010 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.1 0.2 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1 0.2 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.3 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.1 GO:0031493 nucleosomal histone binding(GO:0031493)
0.0 0.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.6 GO:0031492 nucleosomal DNA binding(GO:0031492)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.9 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.5 PID RAS PATHWAY Regulation of Ras family activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 1.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 0.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening