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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nr6a1

Z-value: 1.10

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Transcription factors associated with Nr6a1

Gene Symbol Gene ID Gene Info
Nr6a1
ENSMUSG00000063972.7 nuclear receptor subfamily 6, group A, member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr6a1mm10_v2_chr2_-_38926217_389264540.134.4e-01Click!

Activity profile of Nr6a1 motif

Sorted Z-values of Nr6a1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_107230608 4.46 ENSMUST00000179399.1
A630076J17Rik
RIKEN cDNA A630076J17 gene
chr16_+_22951072 3.26 ENSMUST00000023590.8
Hrg
histidine-rich glycoprotein
chr17_-_57228003 3.00 ENSMUST00000177046.1
ENSMUST00000024988.8
C3
complement component 3
chr6_+_42245907 2.54 ENSMUST00000031897.5
Gstk1
glutathione S-transferase kappa 1
chr7_-_105600103 2.39 ENSMUST00000033185.8
Hpx
hemopexin
chr9_+_73101836 2.12 ENSMUST00000172578.1
Khdc3
KH domain containing 3, subcortical maternal complex member
chr1_+_160978576 2.06 ENSMUST00000064725.5
Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
chr6_-_124636085 1.85 ENSMUST00000068797.2
Gm5077
predicted gene 5077
chr9_-_119157055 1.85 ENSMUST00000010795.4
Acaa1b
acetyl-Coenzyme A acyltransferase 1B
chr5_+_92376954 1.66 ENSMUST00000120781.1
Art3
ADP-ribosyltransferase 3
chr6_+_90333270 1.42 ENSMUST00000164761.1
ENSMUST00000046128.9
Uroc1
urocanase domain containing 1
chr15_+_31572179 1.42 ENSMUST00000161088.1
Cmbl
carboxymethylenebutenolidase-like (Pseudomonas)
chr4_-_82505274 1.40 ENSMUST00000050872.8
ENSMUST00000064770.2
Nfib
nuclear factor I/B
chrX_-_8018492 1.37 ENSMUST00000033503.2
Glod5
glyoxalase domain containing 5
chr2_+_25054396 1.36 ENSMUST00000102931.4
ENSMUST00000074422.7
ENSMUST00000132172.1
ENSMUST00000114388.1
ENSMUST00000114386.1
Nsmf
NMDA receptor synaptonuclear signaling and neuronal migration factor
chr9_+_122805524 1.32 ENSMUST00000052740.7
Tcaim
T cell activation inhibitor, mitochondrial
chr9_+_53301571 1.32 ENSMUST00000051014.1
Exph5
exophilin 5
chr4_-_82505707 1.28 ENSMUST00000107248.1
ENSMUST00000107247.1
Nfib
nuclear factor I/B
chr14_+_78849171 1.27 ENSMUST00000040990.5
Vwa8
von Willebrand factor A domain containing 8
chr11_-_60811228 1.25 ENSMUST00000018744.8
Shmt1
serine hydroxymethyltransferase 1 (soluble)
chr7_-_140881811 1.24 ENSMUST00000106048.3
ENSMUST00000147331.2
ENSMUST00000137710.1
Sirt3
sirtuin 3
chr12_-_28623282 1.18 ENSMUST00000036136.7
Colec11
collectin sub-family member 11
chr1_+_131970589 1.11 ENSMUST00000027695.6
Slc45a3
solute carrier family 45, member 3
chr2_+_127425155 1.08 ENSMUST00000062211.3
ENSMUST00000110373.1
Gpat2
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr10_+_21978643 1.06 ENSMUST00000142174.1
ENSMUST00000164659.1
Sgk1
serum/glucocorticoid regulated kinase 1
chr5_-_108674753 1.04 ENSMUST00000119270.1
ENSMUST00000163328.1
ENSMUST00000136227.1
Slc26a1
solute carrier family 26 (sulfate transporter), member 1
chr13_+_25056004 0.97 ENSMUST00000036932.8
Dcdc2a
doublecortin domain containing 2a
chr4_+_138434647 0.95 ENSMUST00000044058.4
ENSMUST00000105813.1
ENSMUST00000105815.1
Mul1
mitochondrial ubiquitin ligase activator of NFKB 1
chr10_-_68541842 0.93 ENSMUST00000020103.2
1700040L02Rik
RIKEN cDNA 1700040L02 gene
chr14_+_12189943 0.91 ENSMUST00000119888.1
Ptprg
protein tyrosine phosphatase, receptor type, G
chr11_-_100770926 0.91 ENSMUST00000139341.1
ENSMUST00000017891.7
Ghdc
GH3 domain containing
chr4_-_82505749 0.88 ENSMUST00000107245.2
ENSMUST00000107246.1
Nfib
nuclear factor I/B
chr4_-_45530330 0.87 ENSMUST00000061986.5
Shb
src homology 2 domain-containing transforming protein B
chr4_+_155562348 0.84 ENSMUST00000030939.7
Nadk
NAD kinase
chr9_-_50603792 0.83 ENSMUST00000000175.4
Sdhd
succinate dehydrogenase complex, subunit D, integral membrane protein
chr2_+_32606946 0.79 ENSMUST00000113290.1
St6galnac6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr2_+_32606979 0.75 ENSMUST00000113289.1
ENSMUST00000095044.3
St6galnac6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr6_-_57535422 0.68 ENSMUST00000042766.3
Ppm1k
protein phosphatase 1K (PP2C domain containing)
chr2_+_180071793 0.63 ENSMUST00000108901.1
Mtg2
mitochondrial ribosome associated GTPase 2
chr17_-_46645128 0.62 ENSMUST00000003642.6
Klc4
kinesin light chain 4
chr17_-_34804546 0.59 ENSMUST00000025223.8
Cyp21a1
cytochrome P450, family 21, subfamily a, polypeptide 1
chr6_-_113434529 0.59 ENSMUST00000133348.1
Cidec
cell death-inducing DFFA-like effector c
chr18_+_64887690 0.54 ENSMUST00000163516.1
Nedd4l
neural precursor cell expressed, developmentally down-regulated gene 4-like
chr11_-_99244058 0.53 ENSMUST00000103132.3
ENSMUST00000038214.6
Krt222
keratin 222
chr5_-_137611429 0.52 ENSMUST00000031731.7
Pcolce
procollagen C-endopeptidase enhancer protein
chr5_-_137610626 0.52 ENSMUST00000142675.1
Pcolce
procollagen C-endopeptidase enhancer protein
chr6_+_48593927 0.47 ENSMUST00000135151.1
Repin1
replication initiator 1
chr9_+_73102398 0.46 ENSMUST00000034737.6
ENSMUST00000173734.2
ENSMUST00000167514.1
ENSMUST00000174203.2
Khdc3
Gm20509
KH domain containing 3, subcortical maternal complex member
predicted gene 20509
chr2_+_177768044 0.45 ENSMUST00000108942.3
Gm14322
predicted gene 14322
chr5_-_137611372 0.42 ENSMUST00000054564.6
Pcolce
procollagen C-endopeptidase enhancer protein
chr15_-_58364148 0.39 ENSMUST00000068515.7
Anxa13
annexin A13
chr8_-_109693235 0.39 ENSMUST00000034164.4
Ist1
increased sodium tolerance 1 homolog (yeast)
chr12_-_115790884 0.39 ENSMUST00000081809.5
Ighv1-73
immunoglobulin heavy variable 1-73
chr19_+_46707443 0.37 ENSMUST00000003655.7
As3mt
arsenic (+3 oxidation state) methyltransferase
chr4_-_123904826 0.36 ENSMUST00000181292.1
Gm26606
predicted gene, 26606
chr11_-_76763550 0.35 ENSMUST00000010536.8
Gosr1
golgi SNAP receptor complex member 1
chrX_+_140381971 0.34 ENSMUST00000044702.6
Frmpd3
FERM and PDZ domain containing 3
chr6_-_129622685 0.34 ENSMUST00000032252.5
Klrk1
killer cell lectin-like receptor subfamily K, member 1
chr4_+_43632185 0.32 ENSMUST00000107874.2
Npr2
natriuretic peptide receptor 2
chr17_+_72918298 0.32 ENSMUST00000024857.6
Lbh
limb-bud and heart
chr10_-_43540945 0.26 ENSMUST00000147196.1
ENSMUST00000019932.3
1700021F05Rik
RIKEN cDNA 1700021F05 gene
chr11_+_120677226 0.26 ENSMUST00000129644.2
ENSMUST00000151160.1
Aspscr1
alveolar soft part sarcoma chromosome region, candidate 1 (human)
chr12_-_71136611 0.24 ENSMUST00000021486.8
ENSMUST00000166120.1
Timm9
translocase of inner mitochondrial membrane 9
chr9_-_121839460 0.24 ENSMUST00000135986.2
Ccdc13
coiled-coil domain containing 13
chr13_+_113794505 0.20 ENSMUST00000091201.6
Arl15
ADP-ribosylation factor-like 15
chr10_+_23970661 0.20 ENSMUST00000092659.2
Taar5
trace amine-associated receptor 5
chr2_+_172472512 0.20 ENSMUST00000029007.2
Fam209
family with sequence similarity 209
chr2_+_176431829 0.19 ENSMUST00000172025.1
Gm14435
predicted gene 14435
chr1_+_151428612 0.18 ENSMUST00000065625.5
Trmt1l
tRNA methyltransferase 1 like
chr9_+_87144285 0.17 ENSMUST00000113149.1
ENSMUST00000143779.1
ENSMUST00000179313.1
ENSMUST00000049457.7
ENSMUST00000153444.1
Mrap2
melanocortin 2 receptor accessory protein 2
chr9_+_50603892 0.14 ENSMUST00000044051.4
Timm8b
translocase of inner mitochondrial membrane 8B
chr10_+_128083273 0.14 ENSMUST00000026459.5
Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr5_-_136986829 0.13 ENSMUST00000034953.7
ENSMUST00000085941.5
Znhit1
zinc finger, HIT domain containing 1
chr15_-_98165613 0.12 ENSMUST00000143400.1
Asb8
ankyrin repeat and SOCS box-containing 8
chr5_-_123572976 0.10 ENSMUST00000031388.8
Vps33a
vacuolar protein sorting 33A (yeast)
chr7_+_16944645 0.09 ENSMUST00000094807.5
Pnmal2
PNMA-like 2
chr5_+_30232581 0.09 ENSMUST00000145167.1
Ept1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr3_-_96402010 0.06 ENSMUST00000181412.1
4930477E14Rik
RIKEN cDNA 4930477E14 gene
chr11_-_69822144 0.06 ENSMUST00000045771.6
Spem1
sperm maturation 1
chr14_+_76488436 0.05 ENSMUST00000101618.2
Tsc22d1
TSC22 domain family, member 1
chr5_+_136987019 0.05 ENSMUST00000004968.4
Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr1_+_171329015 0.04 ENSMUST00000111300.1
Dedd
death effector domain-containing
chr15_-_98165560 0.04 ENSMUST00000123922.1
Asb8
ankyrin repeat and SOCS box-containing 8
chr1_+_171329376 0.02 ENSMUST00000111299.1
ENSMUST00000064950.4
Dedd
death effector domain-containing

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr6a1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.6 GO:0015886 heme transport(GO:0015886)
0.9 3.6 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.6 3.0 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.3 1.4 GO:0099527 postsynapse to nucleus signaling pathway(GO:0099527)
0.3 2.1 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.3 1.4 GO:0006548 histidine catabolic process(GO:0006548)
0.3 1.1 GO:0015770 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.2 0.9 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production(GO:0071649)
0.2 1.3 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.2 0.8 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.2 1.2 GO:0006545 glycine biosynthetic process(GO:0006545)
0.1 1.0 GO:0019532 oxalate transport(GO:0019532)
0.1 0.8 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 1.5 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 1.2 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.1 1.2 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.3 GO:0048209 regulation of vesicle targeting, to, from or within Golgi(GO:0048209)
0.1 0.3 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.1 1.1 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.1 0.4 GO:0009838 abscission(GO:0009838)
0.1 1.1 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 2.6 GO:0071173 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.1 0.5 GO:2001286 regulation of caveolin-mediated endocytosis(GO:2001286)
0.0 0.2 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 1.7 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.6 GO:0006705 mineralocorticoid biosynthetic process(GO:0006705)
0.0 2.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.6 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.0 0.3 GO:1904672 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147) regulation of somatic stem cell population maintenance(GO:1904672)
0.0 0.6 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.4 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.1 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.5 GO:2001273 regulation of glucose import in response to insulin stimulus(GO:2001273)
0.0 0.9 GO:1901998 toxin transport(GO:1901998)
0.0 0.1 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.7 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.0 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0032010 phagolysosome(GO:0032010)
0.2 0.8 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.2 2.6 GO:0045179 apical cortex(GO:0045179)
0.2 3.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 1.0 GO:0060091 kinocilium(GO:0060091)
0.0 0.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 1.4 GO:0097440 apical dendrite(GO:0097440)
0.0 0.9 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.4 GO:0090543 Flemming body(GO:0090543)
0.0 3.7 GO:0072562 blood microparticle(GO:0072562)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.3 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.1 GO:0033263 CORVET complex(GO:0033263)
0.0 3.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.2 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:0000812 Swr1 complex(GO:0000812)
0.0 1.1 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0015232 heme transporter activity(GO:0015232)
0.4 1.2 GO:0004793 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) serine binding(GO:0070905)
0.3 1.1 GO:0015157 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.3 0.8 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.1 1.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 1.9 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.1 1.7 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1 2.5 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 3.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 1.2 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.3 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.2 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.1 0.5 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.4 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 1.2 GO:0005537 mannose binding(GO:0005537)
0.0 0.8 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 0.4 GO:1901611 phosphatidylglycerol binding(GO:1901611)
0.0 3.3 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.2 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 0.9 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 1.5 GO:0016504 peptidase activator activity(GO:0016504)
0.0 4.4 GO:0004866 endopeptidase inhibitor activity(GO:0004866) endopeptidase regulator activity(GO:0061135)
0.0 0.1 GO:0043532 angiostatin binding(GO:0043532)
0.0 1.4 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.2 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 1.1 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 0.3 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.0 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 1.0 GO:0019894 kinesin binding(GO:0019894)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.0 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 3.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 2.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 1.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.9 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 4.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 PID FOXO PATHWAY FoxO family signaling
0.0 2.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.0 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 2.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 3.6 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.8 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 3.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.6 REACTOME KINESINS Genes involved in Kinesins
0.0 1.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.7 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import