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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Nr5a2
Z-value: 1.90
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Transcription factors associated with Nr5a2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr5a2 | mm10_v2_chr1_-_136953600_136953630 | -0.44 | 7.9e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_60582152 Show fit | 14.44 |
ENSMUST00000098047.2
|
major urinary protein 10 |
|
| chr4_-_61674094 Show fit | 13.40 |
ENSMUST00000098040.3
|
major urinary protein 18 |
|
| chr4_-_61303998 Show fit | 12.87 |
ENSMUST00000071005.8
ENSMUST00000075206.5 |
major urinary protein 14 |
|
| chr4_-_60421933 Show fit | 12.69 |
ENSMUST00000107506.2
ENSMUST00000122381.1 ENSMUST00000118759.1 ENSMUST00000122177.1 |
major urinary protein 9 |
|
| chr4_-_60662358 Show fit | 12.66 |
ENSMUST00000084544.4
ENSMUST00000098046.3 |
major urinary protein 11 |
|
| chr4_-_60222580 Show fit | 12.65 |
ENSMUST00000095058.4
ENSMUST00000163931.1 |
major urinary protein 8 |
|
| chr4_-_61303802 Show fit | 12.32 |
ENSMUST00000125461.1
|
major urinary protein 14 |
|
| chr4_-_60139857 Show fit | 11.86 |
ENSMUST00000107490.4
ENSMUST00000074700.2 |
major urinary protein 2 |
|
| chr4_-_62054112 Show fit | 11.62 |
ENSMUST00000074018.3
|
major urinary protein 20 |
|
| chr13_+_21722057 Show fit | 5.54 |
ENSMUST00000110476.3
|
histone cluster 1, H2bm |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nr5a2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 12.2 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
| 1.9 | 11.6 | GO:0008355 | olfactory learning(GO:0008355) |
| 0.1 | 9.9 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.5 | 6.0 | GO:0002536 | respiratory burst involved in inflammatory response(GO:0002536) |
| 0.0 | 5.2 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.9 | 3.8 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 1.2 | 3.5 | GO:0002014 | vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014) |
| 0.0 | 3.3 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.7 | 2.7 | GO:0033367 | protein localization to secretory granule(GO:0033366) protein localization to mast cell secretory granule(GO:0033367) protease localization to mast cell secretory granule(GO:0033368) maintenance of protein location in mast cell secretory granule(GO:0033370) T cell secretory granule organization(GO:0033371) maintenance of protease location in mast cell secretory granule(GO:0033373) protein localization to T cell secretory granule(GO:0033374) protease localization to T cell secretory granule(GO:0033375) maintenance of protein location in T cell secretory granule(GO:0033377) maintenance of protease location in T cell secretory granule(GO:0033379) granzyme B localization to T cell secretory granule(GO:0033380) maintenance of granzyme B location in T cell secretory granule(GO:0033382) |
| 0.4 | 2.6 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.5 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 7.0 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.4 | 5.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 4.3 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.1 | 3.0 | GO:0005753 | mitochondrial proton-transporting ATP synthase complex(GO:0005753) |
| 0.2 | 2.7 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 2.7 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 2.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 2.4 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 2.4 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 11.6 | GO:0005186 | pheromone activity(GO:0005186) |
| 0.7 | 7.1 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.0 | 6.2 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.1 | 5.5 | GO:0009055 | electron carrier activity(GO:0009055) |
| 0.1 | 5.5 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.2 | 4.8 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 3.4 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.1 | 2.9 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
| 0.0 | 2.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.4 | 2.6 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 4.8 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 3.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 2.3 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 1.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.4 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 1.1 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 1.0 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 1.0 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 1.0 | PID FOXO PATHWAY | FoxO family signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.3 | 10.7 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.2 | 5.7 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 2.6 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 2.6 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 2.4 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 2.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.5 | 2.0 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.1 | 2.0 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 1.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |