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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nkx6-2

Z-value: 2.17

Motif logo

Transcription factors associated with Nkx6-2

Gene Symbol Gene ID Gene Info
ENSMUSG00000041309.11 NK6 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx6-2mm10_v2_chr7_-_139582790_139582808-0.115.3e-01Click!

Activity profile of Nkx6-2 motif

Sorted Z-values of Nkx6-2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_142661858 14.32 ENSMUST00000145896.2
insulin-like growth factor 2
chr7_-_142661305 13.80 ENSMUST00000105936.1
insulin-like growth factor 2
chr18_-_74207771 9.83 ENSMUST00000040188.8
ENSMUST00000177604.1
spindle and kinetochore associated complex subunit 1
chr9_-_123678782 9.43 ENSMUST00000170591.1
ENSMUST00000171647.1
solute carrier family 6 (neurotransmitter transporter), member 20A
chr17_-_48432723 8.97 ENSMUST00000046549.3
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr9_-_123678873 8.16 ENSMUST00000040960.6
solute carrier family 6 (neurotransmitter transporter), member 20A
chr18_+_34840575 7.24 ENSMUST00000043484.7
receptor accessory protein 2
chr16_-_22161450 6.98 ENSMUST00000115379.1
insulin-like growth factor 2 mRNA binding protein 2
chr5_+_66676098 6.57 ENSMUST00000031131.9
ubiquitin carboxy-terminal hydrolase L1
chr14_+_27000362 6.50 ENSMUST00000035433.8
homeobox gene expressed in ES cells
chr19_+_58728887 6.42 ENSMUST00000048644.5
pancreatic lipase related protein 1
chr9_+_65890237 6.31 ENSMUST00000045802.6
RIKEN cDNA 2810417H13 gene
chr10_+_115817247 6.05 ENSMUST00000035563.7
ENSMUST00000080630.3
ENSMUST00000179196.1
tetraspanin 8
chr4_-_117182623 6.00 ENSMUST00000065896.2
kinesin family member 2C
chr17_-_29888570 5.92 ENSMUST00000171691.1
MAM domain containing glycosylphosphatidylinositol anchor 1
chr7_-_4397705 5.80 ENSMUST00000108590.2
glycoprotein 6 (platelet)
chr9_+_96258697 5.25 ENSMUST00000179416.1
transcription factor Dp 2
chr10_+_37139558 5.04 ENSMUST00000062667.3
RIKEN cDNA 5930403N24 gene
chr12_+_117843873 4.92 ENSMUST00000176735.1
ENSMUST00000177339.1
cell division cycle associated 7 like
chr6_-_102464667 4.69 ENSMUST00000032159.6
contactin 3
chr1_-_126830632 4.57 ENSMUST00000112583.1
ENSMUST00000094609.3
NCK-associated protein 5
chr9_+_96259246 3.78 ENSMUST00000179065.1
ENSMUST00000165768.2
transcription factor Dp 2
chr4_-_147642496 3.70 ENSMUST00000133006.1
ENSMUST00000037565.7
ENSMUST00000105720.1
RIKEN cDNA 2610305D13 gene
chr4_-_3938354 3.65 ENSMUST00000003369.3
pleiomorphic adenoma gene 1
chr19_-_33787452 3.55 ENSMUST00000178735.1
ENSMUST00000148137.1
predicted gene 5097
chr5_+_110839973 3.54 ENSMUST00000066160.1
checkpoint kinase 2
chr4_+_140701466 3.49 ENSMUST00000038893.5
ENSMUST00000138808.1
regulator of chromosome condensation 2
chrX_-_59568068 3.12 ENSMUST00000119833.1
ENSMUST00000131319.1
fibroblast growth factor 13
chr13_+_109926832 2.98 ENSMUST00000117420.1
phosphodiesterase 4D, cAMP specific
chr8_+_93810832 2.96 ENSMUST00000034198.8
ENSMUST00000125716.1
guanine nucleotide binding protein, alpha O
chr5_+_65863563 2.91 ENSMUST00000031106.4
ras homolog gene family, member H
chr8_+_21025545 2.88 ENSMUST00000076754.2
defensin, alpha, 21
chr19_+_8802486 2.84 ENSMUST00000172175.1
zinc finger and BTB domain containing 3
chr16_+_44394771 2.80 ENSMUST00000099742.2
WD repeat domain 52
chrX_+_153139941 2.79 ENSMUST00000039720.4
ENSMUST00000144175.2
Ras-related GTP binding B
chr4_+_147553277 2.63 ENSMUST00000139784.1
ENSMUST00000143885.1
ENSMUST00000081742.6
predicted gene 13154
chr17_+_35861343 2.60 ENSMUST00000172931.1
nurim (nuclear envelope membrane protein)
chr1_+_63176818 2.59 ENSMUST00000129339.1
eukaryotic translation elongation factor 1 beta 2
chr2_-_125625065 2.48 ENSMUST00000089776.2
centrosomal protein 152
chr17_+_35861318 2.48 ENSMUST00000074259.8
ENSMUST00000174873.1
nurim (nuclear envelope membrane protein)
chr8_-_62123106 2.42 ENSMUST00000034052.6
ENSMUST00000034054.7
annexin A10
chr4_+_127172866 2.35 ENSMUST00000106094.2
discs, large (Drosophila) homolog-associated protein 3
chr1_+_170308802 2.34 ENSMUST00000056991.5
RIKEN cDNA 1700015E13 gene
chr5_-_110839757 2.33 ENSMUST00000056937.5
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr3_-_17230976 2.31 ENSMUST00000177874.1
predicted gene 5283
chr7_+_28788955 2.30 ENSMUST00000059857.7
Ras and Rab interactor-like
chrX_+_75382384 2.25 ENSMUST00000033541.4
FUN14 domain containing 2
chr17_+_82539258 2.23 ENSMUST00000097278.3
predicted pseudogene 6594
chr17_-_78684262 2.22 ENSMUST00000145480.1
striatin, calmodulin binding protein
chr8_+_21162277 2.16 ENSMUST00000098897.1
defensin, alpha, 22
chr9_-_35558522 2.14 ENSMUST00000034612.5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr8_+_21565368 2.14 ENSMUST00000084040.2
predicted gene 14850
chr11_+_20543307 2.08 ENSMUST00000093292.4
SERTA domain containing 2
chr5_-_122821298 2.07 ENSMUST00000086216.4
anaphase-promoting complex subunit 5
chr11_+_23256566 2.07 ENSMUST00000136235.1
exportin 1, CRM1 homolog (yeast)
chr14_+_51129055 2.06 ENSMUST00000095923.3
ribonuclease, RNase A family, 6
chrX_-_59567348 2.04 ENSMUST00000124402.1
fibroblast growth factor 13
chr15_-_81104999 2.02 ENSMUST00000109579.2
MKL (megakaryoblastic leukemia)/myocardin-like 1
chr11_+_46810792 1.93 ENSMUST00000068877.6
T cell immunoglobulin and mucin domain containing 4
chr1_-_126830786 1.88 ENSMUST00000162646.1
NCK-associated protein 5
chr5_-_110839575 1.86 ENSMUST00000145318.1
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr4_+_150927918 1.85 ENSMUST00000139826.1
ENSMUST00000116257.1
tumor necrosis factor receptor superfamily, member 9
chr18_+_68337504 1.83 ENSMUST00000172148.1
melanocortin 5 receptor
chr8_-_105568298 1.81 ENSMUST00000005849.5
agouti related protein
chr11_+_105092194 1.74 ENSMUST00000021029.5
EF-hand calcium binding domain 3
chr5_-_20951769 1.69 ENSMUST00000036489.5
round spermatid basic protein 1-like
chr4_+_146097312 1.67 ENSMUST00000105730.1
ENSMUST00000091878.5
predicted gene 13051
chr4_-_136835843 1.66 ENSMUST00000105846.2
ENSMUST00000059287.7
ENSMUST00000105845.2
Eph receptor B2
chr10_-_37138863 1.65 ENSMUST00000092584.5
myristoylated alanine rich protein kinase C substrate
chr2_-_33087169 1.63 ENSMUST00000102810.3
GTPase activating RANGAP domain-like 3
chr7_+_25228687 1.62 ENSMUST00000169914.1
RIKEN cDNA 9130221H12 gene
chr11_-_17953861 1.54 ENSMUST00000076661.6
Ewing's tumor-associated antigen 1
chr5_+_19907502 1.53 ENSMUST00000101558.3
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr15_+_99006056 1.52 ENSMUST00000079818.3
predicted gene 8973
chr6_+_125552948 1.52 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
Von Willebrand factor homolog
chr8_-_65129317 1.52 ENSMUST00000098713.3
cDNA sequence BC030870
chr5_-_131308076 1.48 ENSMUST00000160609.1
Williams-Beuren syndrome chromosome region 17 homolog (human)
chr12_-_46818749 1.45 ENSMUST00000021438.6
neuro-oncological ventral antigen 1
chr5_+_25246775 1.40 ENSMUST00000144971.1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr2_+_62664279 1.40 ENSMUST00000028257.2
grancalcin
chr8_+_21427456 1.37 ENSMUST00000095424.4
predicted gene, 21498
chr7_+_142831227 1.25 ENSMUST00000097935.2
predicted gene 6471
chr11_-_87826023 1.24 ENSMUST00000103177.3
lactoperoxidase
chr11_-_107348130 1.23 ENSMUST00000134763.1
phosphatidylinositol transfer protein, cytoplasmic 1
chr18_-_43477764 1.20 ENSMUST00000057110.9
eukaryotic translation initiation factor 3, subunit J2
chr1_+_66321708 1.19 ENSMUST00000114013.1
microtubule-associated protein 2
chr6_-_13839916 1.19 ENSMUST00000060442.7
G protein-coupled receptor 85
chr3_+_10088173 1.17 ENSMUST00000061419.7
predicted gene 9833
chr16_+_96467606 1.17 ENSMUST00000061739.8
Purkinje cell protein 4
chr2_+_69861562 1.17 ENSMUST00000090852.4
ENSMUST00000166411.1
Sjogren syndrome antigen B
chr18_-_31911903 1.16 ENSMUST00000054984.6
SFT2 domain containing 3
chr8_+_25720054 1.16 ENSMUST00000068916.8
ENSMUST00000139836.1
phosphatidic acid phosphatase type 2 domain containing 1B
chr6_-_87533219 1.14 ENSMUST00000113637.2
ENSMUST00000071024.6
Rho GTPase activating protein 25
chr1_+_66322102 1.13 ENSMUST00000123647.1
microtubule-associated protein 2
chr4_+_147361303 1.11 ENSMUST00000133078.1
ENSMUST00000154154.1
predicted gene 13145
chr2_-_45117349 1.11 ENSMUST00000176438.2
zinc finger E-box binding homeobox 2
chr8_+_21665797 1.11 ENSMUST00000075268.4
predicted gene 15315
chr4_-_146909590 1.05 ENSMUST00000049821.3
predicted gene, 21411
chr8_-_107439585 1.05 ENSMUST00000077208.4
ribosomal protein S26, pseudogene 1
chr5_+_75152274 1.03 ENSMUST00000000476.8
platelet derived growth factor receptor, alpha polypeptide
chr2_+_3114220 1.02 ENSMUST00000072955.5
family with sequence similarity 171, member A1
chr2_+_157367594 1.01 ENSMUST00000081202.5
mannosidase, beta A, lysosomal-like
chr19_-_14597983 0.97 ENSMUST00000052011.7
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr3_+_83055516 0.97 ENSMUST00000150268.1
ENSMUST00000122128.1
pleiotropic regulator 1, PRL1 homolog (Arabidopsis)
chr4_+_109343029 0.95 ENSMUST00000030281.5
epidermal growth factor receptor pathway substrate 15
chr19_-_14598031 0.95 ENSMUST00000167776.2
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr6_-_119963733 0.95 ENSMUST00000161512.2
WNK lysine deficient protein kinase 1
chrX_+_134059315 0.94 ENSMUST00000144483.1
cleavage stimulation factor, 3' pre-RNA subunit 2
chr2_+_163694015 0.92 ENSMUST00000109400.2
protein kinase inhibitor, gamma
chr4_+_3940747 0.91 ENSMUST00000119403.1
coiled-coil-helix-coiled-coil-helix domain containing 7
chr2_-_33086366 0.90 ENSMUST00000049618.2
GTPase activating RANGAP domain-like 3
chr16_-_76403673 0.89 ENSMUST00000052867.7
predicted gene 9843
chr1_-_135585314 0.86 ENSMUST00000040599.8
ENSMUST00000067414.6
neuron navigator 1
chr3_+_68572245 0.86 ENSMUST00000170788.2
schwannomin interacting protein 1
chr15_+_18818895 0.85 ENSMUST00000166873.2
cadherin 10
chr3_+_107291215 0.84 ENSMUST00000029502.7
solute carrier family 16 (monocarboxylic acid transporters), member 4
chr4_+_147305674 0.82 ENSMUST00000148762.3
predicted gene 13151
chr6_+_127149389 0.81 ENSMUST00000180811.1
RIKEN cDNA 9330179D12 gene
chr9_-_22117123 0.69 ENSMUST00000013966.6
elongation factor 1 homolog (ELF1, S. cerevisiae)
chr18_-_63387124 0.68 ENSMUST00000047480.6
ENSMUST00000046860.5
piezo-type mechanosensitive ion channel component 2
chr12_-_80760541 0.63 ENSMUST00000073251.6
coiled-coil domain containing 177
chr18_+_6332587 0.61 ENSMUST00000097682.2
ribosomal protein L27, pseudogene 3
chr4_+_146502027 0.61 ENSMUST00000105735.2
predicted gene 13247
chr15_+_34453285 0.59 ENSMUST00000060894.7
cDNA sequence BC030476
chr3_+_19894855 0.59 ENSMUST00000059704.4
RIKEN cDNA 4632415L05 gene
chr10_+_26822560 0.52 ENSMUST00000135866.1
Rho GTPase activating protein 18
chr15_-_13173607 0.52 ENSMUST00000036439.4
cadherin 6
chr7_+_39588931 0.50 ENSMUST00000178791.1
ENSMUST00000098511.3
predicted gene 2058
chr3_+_96221111 0.50 ENSMUST00000090781.6
histone cluster 2, H2be
chr1_-_64121456 0.50 ENSMUST00000142009.1
ENSMUST00000114086.1
Kruppel-like factor 7 (ubiquitous)
chr9_-_119719032 0.48 ENSMUST00000084787.5
sodium channel, voltage-gated, type X, alpha
chr11_+_115933282 0.47 ENSMUST00000140991.1
SAP30 binding protein
chr1_-_9944103 0.47 ENSMUST00000182498.1
ENSMUST00000182742.1
ENSMUST00000182580.1
small nucleolar RNA host gene (non-protein coding) 6
chr10_+_19621992 0.46 ENSMUST00000036564.7
interleukin 22 receptor, alpha 2
chr9_-_113708209 0.46 ENSMUST00000111861.3
ENSMUST00000035086.6
programmed cell death 6 interacting protein
chr4_+_148558422 0.45 ENSMUST00000017408.7
ENSMUST00000076022.6
exosome component 10
chr11_+_100859492 0.43 ENSMUST00000107356.1
signal transducer and activator of transcription 5A
chr2_-_174346712 0.43 ENSMUST00000168292.1
predicted gene, 20721
chr11_+_67321638 0.42 ENSMUST00000108684.1
myosin, heavy polypeptide 13, skeletal muscle
chr4_-_133756769 0.40 ENSMUST00000008024.6
AT rich interactive domain 1A (SWI-like)
chr10_+_79910856 0.38 ENSMUST00000181321.1
predicted gene, 26602
chr5_-_131307848 0.38 ENSMUST00000086023.5
Williams-Beuren syndrome chromosome region 17 homolog (human)
chr18_+_4993795 0.33 ENSMUST00000153016.1
supervillin
chr4_-_147702553 0.33 ENSMUST00000117638.1
zinc finger protein 534
chr11_-_115933464 0.32 ENSMUST00000021097.3
RecQ protein-like 5
chr3_+_3634145 0.31 ENSMUST00000108394.1
hepatocyte nuclear factor 4, gamma
chr2_+_69219971 0.31 ENSMUST00000005364.5
ENSMUST00000112317.2
glucose-6-phosphatase, catalytic, 2
chr3_+_69222412 0.28 ENSMUST00000183126.1
ADP-ribosylation factor-like 14
chr1_+_34005872 0.28 ENSMUST00000182296.1
dystonin
chr3_+_106113229 0.27 ENSMUST00000079132.5
ENSMUST00000139086.1
chitinase, acidic
chr13_-_27513206 0.25 ENSMUST00000018389.3
ENSMUST00000110350.1
prolactin family 8, subfamily a, member 81
chr19_-_33517776 0.24 ENSMUST00000112511.3
ENSMUST00000143522.1
lipase, member O4
chr1_-_185329331 0.23 ENSMUST00000027921.4
ENSMUST00000110975.1
ENSMUST00000110974.3
isoleucine-tRNA synthetase 2, mitochondrial
chr5_+_140419248 0.22 ENSMUST00000100507.3
eukaryotic translation initiation factor 3, subunit B
chr13_+_44121167 0.21 ENSMUST00000163056.1
ENSMUST00000159595.1
predicted gene 5083
chrX_-_75382615 0.21 ENSMUST00000147349.1
coagulation factor VIII
chr11_-_4440745 0.20 ENSMUST00000109948.1
HORMA domain containing 2
chr16_-_16829276 0.18 ENSMUST00000023468.5
sperm associated antigen 6
chr5_+_123142187 0.18 ENSMUST00000174836.1
ENSMUST00000163030.2
SET domain containing 1B
chr11_+_100859351 0.18 ENSMUST00000004145.7
ENSMUST00000133036.1
signal transducer and activator of transcription 5A
chr7_+_45062429 0.17 ENSMUST00000107830.1
ENSMUST00000003513.3
ENSMUST00000107829.1
ENSMUST00000150609.1
nitric oxide synthase interacting protein
chr5_+_20702129 0.16 ENSMUST00000101556.4
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr5_+_43515513 0.16 ENSMUST00000167522.1
ENSMUST00000144558.1
ENSMUST00000076939.6
C1q and tumor necrosis factor related protein 7
chr11_-_109995743 0.16 ENSMUST00000106669.2
ATP-binding cassette, sub-family A (ABC1), member 8b
chr5_-_137142413 0.14 ENSMUST00000160533.1
mucin 3, intestinal
chr4_+_146971976 0.13 ENSMUST00000146688.2
predicted gene 13150
chr18_-_42899294 0.13 ENSMUST00000117687.1
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr11_-_109995775 0.13 ENSMUST00000020948.8
ATP-binding cassette, sub-family A (ABC1), member 8b
chr2_-_177267036 0.11 ENSMUST00000108963.1
predicted gene 14409
chr11_+_98863610 0.11 ENSMUST00000142414.1
ENSMUST00000037480.8
WAS/WASL interacting protein family, member 2
chrX_-_43274786 0.10 ENSMUST00000016294.7
teneurin transmembrane protein 1
chr10_-_127311740 0.08 ENSMUST00000037290.5
ENSMUST00000171564.1
methionine-tRNA synthetase
chrX_-_112405822 0.01 ENSMUST00000124335.1
spermidine/spermine N1-acetyl transferase-like 1
chr13_+_41148796 0.01 ENSMUST00000141292.1
synaptonemal complex protein 2-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx6-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 17.6 GO:0035524 proline transmembrane transport(GO:0035524)
3.5 28.1 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
1.2 7.2 GO:0050916 sensory perception of sweet taste(GO:0050916)
1.2 6.0 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.2 3.5 GO:0098763 mitotic cell cycle phase(GO:0098763)
1.1 6.6 GO:0007412 axon target recognition(GO:0007412)
0.8 5.9 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.7 5.2 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.7 6.5 GO:0030916 otic vesicle formation(GO:0030916)
0.6 6.4 GO:0016554 cytidine to uridine editing(GO:0016554)
0.6 4.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.6 3.5 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.5 1.9 GO:2001183 negative regulation of interleukin-12 secretion(GO:2001183)
0.4 2.5 GO:0098535 de novo centriole assembly(GO:0098535)
0.3 1.0 GO:0072276 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.3 2.0 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.3 1.2 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.3 5.8 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.3 2.8 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.3 2.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.2 0.9 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.2 3.0 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 1.7 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
0.2 1.0 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.2 1.1 GO:0061373 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748)
0.2 1.4 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.2 1.6 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.2 3.6 GO:0060736 prostate gland growth(GO:0060736)
0.2 1.4 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.2 0.5 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.2 0.6 GO:0060376 positive regulation of mast cell differentiation(GO:0060376)
0.1 0.5 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.1 12.4 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.1 6.1 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 0.4 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.1 0.3 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 0.9 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 0.2 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.1 1.5 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 1.2 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.1 9.1 GO:0051028 mRNA transport(GO:0051028)
0.1 2.6 GO:0019731 antibacterial humoral response(GO:0019731)
0.1 3.0 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 0.5 GO:0086028 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043)
0.1 1.6 GO:0051764 actin crosslink formation(GO:0051764)
0.1 2.1 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 0.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 2.6 GO:0006414 translational elongation(GO:0006414)
0.0 0.2 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.9 GO:0001553 luteinization(GO:0001553)
0.0 0.7 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 2.9 GO:0045576 mast cell activation(GO:0045576)
0.0 6.0 GO:0042742 defense response to bacterium(GO:0042742)
0.0 1.8 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 0.2 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0 0.1 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.7 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 1.5 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 1.5 GO:0001889 liver development(GO:0001889)
0.0 1.4 GO:0050684 regulation of mRNA processing(GO:0050684)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 9.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.6 2.8 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.5 1.6 GO:0042585 germinal vesicle(GO:0042585)
0.5 5.8 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.4 2.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.4 2.5 GO:0098536 deuterosome(GO:0098536)
0.3 0.9 GO:0071920 cleavage body(GO:0071920)
0.3 3.5 GO:1990023 mitotic spindle midzone(GO:1990023)
0.3 5.1 GO:0005652 nuclear lamina(GO:0005652)
0.3 1.8 GO:0005796 Golgi lumen(GO:0005796)
0.3 2.3 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 2.1 GO:0005642 annulate lamellae(GO:0005642)
0.2 6.0 GO:0035371 microtubule plus-end(GO:0035371)
0.1 1.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.2 GO:0005883 neurofilament(GO:0005883)
0.1 2.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.5 GO:0044299 C-fiber(GO:0044299)
0.1 2.1 GO:0033391 chromatoid body(GO:0033391)
0.1 7.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 2.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 5.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 1.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 2.1 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 1.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 1.0 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 1.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 5.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 3.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 3.4 GO:0001772 immunological synapse(GO:0001772)
0.1 1.5 GO:0043596 nuclear replication fork(GO:0043596)
0.0 9.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.3 GO:0031673 H zone(GO:0031673)
0.0 0.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.9 GO:0043194 axon initial segment(GO:0043194)
0.0 3.5 GO:0016605 PML body(GO:0016605)
0.0 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 6.6 GO:0044306 neuron projection terminus(GO:0044306)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 2.6 GO:0001650 fibrillar center(GO:0001650)
0.0 1.0 GO:0005902 microvillus(GO:0005902)
0.0 5.7 GO:0016324 apical plasma membrane(GO:0016324)
0.0 22.8 GO:0005615 extracellular space(GO:0005615)
0.0 0.3 GO:0043034 costamere(GO:0043034)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.6 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
1.6 17.6 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.5 9.0 GO:0004126 cytidine deaminase activity(GO:0004126)
0.8 29.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.5 5.8 GO:0038064 collagen receptor activity(GO:0038064)
0.4 3.0 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.4 6.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.4 6.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 1.8 GO:0004977 melanocortin receptor activity(GO:0004977)
0.3 2.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 7.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 1.7 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 2.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.2 1.0 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.2 1.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 0.5 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.1 2.0 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 6.1 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 2.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 2.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 4.2 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.3 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 1.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 1.5 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 1.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.2 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.1 1.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.7 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 2.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.9 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.9 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 1.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.3 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 13.6 GO:0008017 microtubule binding(GO:0008017)
0.0 2.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 6.5 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 1.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 2.9 GO:0019210 kinase inhibitor activity(GO:0019210)
0.0 2.1 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 1.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.9 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.7 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 1.6 GO:0005080 protein kinase C binding(GO:0005080)
0.0 2.5 GO:0004540 ribonuclease activity(GO:0004540)
0.0 1.2 GO:0004601 peroxidase activity(GO:0004601)
0.0 11.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 6.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.4 GO:0005178 integrin binding(GO:0005178)
0.0 4.3 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 0.5 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.0 0.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 2.4 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 21.7 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 3.0 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 6.6 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 1.8 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 6.0 PID AURORA B PATHWAY Aurora B signaling
0.1 2.1 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 8.3 PID E2F PATHWAY E2F transcription factor network
0.1 3.5 PID ATM PATHWAY ATM pathway
0.1 1.7 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 2.2 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.0 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.6 PID IL5 PATHWAY IL5-mediated signaling events
0.0 2.3 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.9 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.0 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.9 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.8 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.3 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 28.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4 3.5 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 6.0 REACTOME KINESINS Genes involved in Kinesins
0.2 2.1 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.6 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 13.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.1 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.1 1.0 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.1 1.5 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 3.0 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 3.0 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 3.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 0.9 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 3.3 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 7.0 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.0 1.2 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.0 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 4.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.8 REACTOME TRANSLATION Genes involved in Translation
0.0 1.4 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 0.2 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation