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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Neurog2
Z-value: 1.91
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Transcription factors associated with Neurog2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Neurog2 | mm10_v2_chr3_+_127633134_127633140 | 0.54 | 6.7e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_90490714 Show fit | 18.35 |
ENSMUST00000042755.3
|
alpha fetoprotein |
|
| chr11_-_102365111 Show fit | 14.50 |
ENSMUST00000006749.9
|
solute carrier family 4 (anion exchanger), member 1 |
|
| chr13_+_54701457 Show fit | 8.96 |
ENSMUST00000037145.7
|
cadherin-related family member 2 |
|
| chr4_-_118457450 Show fit | 8.23 |
ENSMUST00000106375.1
ENSMUST00000006556.3 ENSMUST00000168404.1 |
myeloproliferative leukemia virus oncogene |
|
| chr9_-_70421533 Show fit | 8.21 |
ENSMUST00000034742.6
|
cyclin B2 |
|
| chr4_-_118457509 Show fit | 7.83 |
ENSMUST00000102671.3
|
myeloproliferative leukemia virus oncogene |
|
| chr11_-_69602741 Show fit | 7.45 |
ENSMUST00000138694.1
|
ATPase, Na+/K+ transporting, beta 2 polypeptide |
|
| chr8_-_107065632 Show fit | 7.31 |
ENSMUST00000034393.5
|
transmembrane emp24 protein transport domain containing 6 |
|
| chr7_+_30699783 Show fit | 6.40 |
ENSMUST00000013227.7
|
RIKEN cDNA 2200002J24 gene |
|
| chr7_-_126704816 Show fit | 6.38 |
ENSMUST00000032949.7
|
coronin, actin binding protein 1A |
Network of associatons between targets according to the STRING database.
First level regulatory network of Neurog2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 18.4 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 2.9 | 17.3 | GO:0032796 | uropod organization(GO:0032796) |
| 5.4 | 16.1 | GO:0035702 | monocyte homeostasis(GO:0035702) |
| 0.5 | 14.5 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 4.0 | 12.0 | GO:0034224 | cellular response to zinc ion starvation(GO:0034224) |
| 1.8 | 9.0 | GO:1904970 | brush border assembly(GO:1904970) |
| 1.9 | 7.4 | GO:1903288 | positive regulation of potassium ion import(GO:1903288) |
| 1.3 | 6.5 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 0.7 | 6.5 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 1.5 | 5.9 | GO:0002767 | immune response-inhibiting cell surface receptor signaling pathway(GO:0002767) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 17.3 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.2 | 17.3 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.0 | 12.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 9.5 | GO:0009986 | cell surface(GO:0009986) |
| 0.9 | 9.0 | GO:0089717 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 0.0 | 8.5 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.8 | 7.4 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 6.5 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 6.1 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 5.3 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 19.1 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 4.6 | 18.4 | GO:0004566 | beta-glucuronidase activity(GO:0004566) |
| 0.1 | 16.1 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.7 | 14.5 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.3 | 12.0 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.2 | 12.0 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 11.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.7 | 7.4 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 2.2 | 6.5 | GO:0005151 | interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353) |
| 0.0 | 5.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 9.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 8.2 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 6.5 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.3 | 4.4 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 3.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 3.2 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 3.0 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 2.8 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 2.3 | PID S1P S1P4 PATHWAY | S1P4 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.1 | REACTOME PLATELET AGGREGATION PLUG FORMATION | Genes involved in Platelet Aggregation (Plug Formation) |
| 0.1 | 14.5 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.5 | 12.0 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.3 | 11.8 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.5 | 8.2 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 6.5 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 4.5 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.2 | 3.2 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 3.2 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 2.8 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |