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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Mtf1
Z-value: 1.55
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Transcription factors associated with Mtf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mtf1 | mm10_v2_chr4_+_124802543_124802678 | 0.53 | 9.7e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_94172618 Show fit | 25.30 |
ENSMUST00000034214.6
|
metallothionein 2 |
|
| chr8_+_94179089 Show fit | 17.13 |
ENSMUST00000034215.6
|
metallothionein 1 |
|
| chr9_+_98490522 Show fit | 13.23 |
ENSMUST00000035029.2
|
retinol binding protein 2, cellular |
|
| chr6_+_90619241 Show fit | 4.59 |
ENSMUST00000032177.8
|
solute carrier family 41, member 3 |
|
| chr9_-_14381242 Show fit | 4.40 |
ENSMUST00000167549.1
|
endonuclease domain containing 1 |
|
| chr1_-_169531343 Show fit | 4.37 |
ENSMUST00000028000.7
|
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) |
|
| chr9_-_56635624 Show fit | 3.95 |
ENSMUST00000114256.1
|
leucine rich repeat and Ig domain containing 1 |
|
| chr1_+_75400070 Show fit | 3.89 |
ENSMUST00000113589.1
|
SPEG complex locus |
|
| chr1_-_169531447 Show fit | 3.72 |
ENSMUST00000111368.1
|
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) |
|
| chr4_+_103619580 Show fit | 3.32 |
ENSMUST00000106827.1
|
disabled 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Mtf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.1 | 42.4 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
| 1.7 | 13.2 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 1.3 | 9.2 | GO:0051410 | detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458) |
| 0.2 | 8.1 | GO:0008608 | attachment of spindle microtubules to kinetochore(GO:0008608) |
| 0.9 | 5.4 | GO:0042891 | antibiotic transport(GO:0042891) |
| 0.2 | 4.8 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.2 | 4.0 | GO:0048715 | negative regulation of oligodendrocyte differentiation(GO:0048715) |
| 0.0 | 3.9 | GO:0055013 | cardiac muscle cell development(GO:0055013) |
| 0.0 | 3.6 | GO:1902017 | regulation of cilium assembly(GO:1902017) |
| 1.1 | 3.3 | GO:0021577 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.2 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 9.6 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.5 | 9.2 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 1.3 | 8.1 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.0 | 5.4 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.2 | 4.8 | GO:0043218 | compact myelin(GO:0043218) |
| 0.2 | 3.6 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.0 | 3.3 | GO:0005903 | brush border(GO:0005903) |
| 0.2 | 3.0 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 2.7 | GO:0035861 | site of double-strand break(GO:0035861) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.7 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.2 | 15.5 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.9 | 13.2 | GO:0019841 | retinal binding(GO:0016918) retinol binding(GO:0019841) |
| 0.3 | 9.2 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 1.1 | 5.4 | GO:0042895 | antibiotic transporter activity(GO:0042895) |
| 0.0 | 4.4 | GO:0004519 | endonuclease activity(GO:0004519) |
| 0.1 | 4.0 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 3.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 3.3 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.2 | 2.9 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.8 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 4.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 4.0 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 3.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 3.3 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.4 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 1.1 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.0 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.9 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 0.6 | PID SHP2 PATHWAY | SHP2 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.2 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.3 | 12.1 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 8.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 4.0 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.1 | 2.7 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 1.6 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 1.5 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 1.5 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.1 | 1.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 1.4 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |