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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Mef2d_Mef2a
Z-value: 1.49
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Transcription factors associated with Mef2d_Mef2a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mef2d | mm10_v2_chr3_+_88142328_88142483 | 0.21 | 2.1e-01 | Click! |
| Mef2a | mm10_v2_chr7_-_67372846_67372858 | 0.10 | 5.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Mef2d_Mef2a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 56.9 | GO:0006941 | striated muscle contraction(GO:0006941) |
| 0.9 | 41.8 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.5 | 34.0 | GO:0030239 | myofibril assembly(GO:0030239) |
| 2.4 | 23.9 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 3.2 | 19.2 | GO:0030241 | skeletal muscle myosin thick filament assembly(GO:0030241) |
| 1.8 | 15.8 | GO:0032264 | IMP salvage(GO:0032264) |
| 2.1 | 14.9 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
| 0.1 | 10.8 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.1 | 9.5 | GO:0032233 | positive regulation of actin filament bundle assembly(GO:0032233) |
| 1.8 | 8.8 | GO:0071313 | cellular response to caffeine(GO:0071313) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 65.9 | GO:0030018 | Z disc(GO:0030018) |
| 1.5 | 39.4 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.5 | 33.6 | GO:0016459 | myosin complex(GO:0016459) |
| 1.9 | 33.3 | GO:0005861 | troponin complex(GO:0005861) |
| 2.5 | 22.7 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 2.8 | 19.4 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 5.0 | 14.9 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 1.3 | 13.4 | GO:0032982 | myosin filament(GO:0032982) |
| 0.5 | 10.4 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 2.8 | 8.4 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 56.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 1.9 | 50.7 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 5.6 | 27.8 | GO:0051373 | FATZ binding(GO:0051373) |
| 2.2 | 22.3 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.4 | 18.0 | GO:0003785 | actin monomer binding(GO:0003785) |
| 1.8 | 15.8 | GO:0047623 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.1 | 15.3 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 12.0 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 1.6 | 9.3 | GO:0030899 | calcium-dependent ATPase activity(GO:0030899) |
| 0.1 | 8.2 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 14.9 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 3.1 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 3.0 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.2 | 2.5 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 2.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.5 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 1.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 1.0 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.9 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 119.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.8 | 15.8 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.1 | 12.4 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.4 | 8.0 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.2 | 7.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.2 | 5.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.5 | 5.0 | REACTOME DEFENSINS | Genes involved in Defensins |
| 0.1 | 4.2 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.1 | 4.1 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.1 | 3.3 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |