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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Max_Mycn
Z-value: 1.26
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Transcription factors associated with Max_Mycn
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mycn | mm10_v2_chr12_-_12940600_12940616 | 0.37 | 2.6e-02 | Click! |
| Max | mm10_v2_chr12_-_76962178_76962248 | 0.31 | 6.3e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Max_Mycn
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.4 | GO:0006414 | translational elongation(GO:0006414) |
| 3.0 | 8.9 | GO:0006226 | dUMP biosynthetic process(GO:0006226) |
| 0.1 | 8.4 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.1 | 6.3 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.1 | 6.0 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.4 | 5.9 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
| 1.8 | 5.5 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 0.4 | 5.4 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 1.0 | 5.2 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.9 | 5.2 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 18.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 14.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 10.0 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.2 | 8.2 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 1.2 | 7.1 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.3 | 6.2 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.7 | 5.9 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.1 | 5.6 | GO:0005844 | polysome(GO:0005844) |
| 0.1 | 5.4 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 5.4 | GO:0005840 | ribosome(GO:0005840) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 25.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.6 | 13.2 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.3 | 12.6 | GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814) |
| 0.3 | 10.6 | GO:0008187 | poly-pyrimidine tract binding(GO:0008187) |
| 0.1 | 8.0 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.1 | 7.0 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 1.1 | 6.9 | GO:0031493 | nucleosomal histone binding(GO:0031493) |
| 1.5 | 5.9 | GO:0031721 | hemoglobin alpha binding(GO:0031721) |
| 0.1 | 5.6 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.8 | 4.9 | GO:1990932 | 5.8S rRNA binding(GO:1990932) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 11.5 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.6 | 9.9 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 8.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 6.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 5.3 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 5.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.2 | 5.0 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 4.9 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 3.2 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 23.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.2 | 15.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 14.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 9.9 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.3 | 8.5 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.2 | 7.9 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 7.5 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.4 | 6.7 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 6.4 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.3 | 6.1 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |