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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Klf16_Sp8
Z-value: 2.23
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Transcription factors associated with Klf16_Sp8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Klf16 | mm10_v2_chr10_-_80577285_80577327 | -0.82 | 1.1e-09 | Click! |
| Sp8 | mm10_v2_chr12_+_118846329_118846329 | 0.04 | 8.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Klf16_Sp8
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 26.6 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 1.4 | 26.5 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 1.1 | 25.3 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.8 | 23.3 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 3.8 | 22.7 | GO:0006663 | platelet activating factor biosynthetic process(GO:0006663) |
| 0.5 | 20.2 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 6.0 | 18.0 | GO:0048627 | myoblast development(GO:0048627) |
| 1.5 | 17.5 | GO:0034626 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 1.9 | 17.4 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) |
| 5.3 | 16.0 | GO:0019859 | pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 160.5 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.5 | 101.2 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.3 | 81.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 55.9 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.4 | 48.7 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.2 | 48.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 1.7 | 27.2 | GO:0034385 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 1.6 | 25.2 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.3 | 22.6 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.6 | 22.5 | GO:0030673 | axolemma(GO:0030673) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 30.0 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 0.5 | 26.1 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.6 | 24.8 | GO:0016790 | thiolester hydrolase activity(GO:0016790) |
| 0.3 | 24.5 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 4.7 | 23.7 | GO:0004142 | diacylglycerol cholinephosphotransferase activity(GO:0004142) |
| 2.0 | 17.9 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 1.5 | 17.5 | GO:0102336 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.3 | 16.9 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 3.1 | 15.3 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) |
| 2.5 | 15.2 | GO:0016401 | palmitoyl-CoA oxidase activity(GO:0016401) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 40.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 23.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 22.2 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.5 | 19.7 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.3 | 17.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.7 | 16.8 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.2 | 15.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.3 | 13.9 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.3 | 13.4 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.2 | 12.0 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 59.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 1.8 | 45.9 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.5 | 44.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 1.6 | 35.6 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 1.1 | 32.5 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.9 | 32.2 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 1.3 | 29.1 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.8 | 26.3 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.3 | 20.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.9 | 16.3 | REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |