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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Klf12_Klf14_Sp4
Z-value: 1.69
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Transcription factors associated with Klf12_Klf14_Sp4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Klf14 | mm10_v2_chr6_-_30958990_30958990 | -0.67 | 8.0e-06 | Click! |
| Klf12 | mm10_v2_chr14_-_100149764_100149764 | -0.26 | 1.2e-01 | Click! |
| Sp4 | mm10_v2_chr12_-_118301429_118301458 | -0.25 | 1.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_108334341 Show fit | 5.58 |
ENSMUST00000021684.4
|
cytochrome P450, family 46, subfamily a, polypeptide 1 |
|
| chr14_-_61556746 Show fit | 5.40 |
ENSMUST00000100496.4
|
SPRY domain containing 7 |
|
| chr8_+_114133635 Show fit | 4.41 |
ENSMUST00000147605.1
ENSMUST00000134593.1 |
nudix (nucleoside diphosphate linked moiety X)-type motif 7 |
|
| chr14_-_61556881 Show fit | 4.37 |
ENSMUST00000022497.8
|
SPRY domain containing 7 |
|
| chr2_+_155517948 Show fit | 4.27 |
ENSMUST00000029135.8
ENSMUST00000065973.2 ENSMUST00000103142.5 |
acyl-CoA synthetase short-chain family member 2 |
|
| chr19_+_46131888 Show fit | 4.12 |
ENSMUST00000043739.3
|
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 |
|
| chr2_+_31470207 Show fit | 4.04 |
ENSMUST00000102840.4
|
argininosuccinate synthetase 1 |
|
| chr7_+_24611314 Show fit | 3.36 |
ENSMUST00000073325.5
|
pleckstrin homology-like domain, family B, member 3 |
|
| chr7_+_6286573 Show fit | 3.23 |
ENSMUST00000086327.5
|
zinc finger protein 667 |
|
| chr12_-_104044431 Show fit | 3.22 |
ENSMUST00000043915.3
|
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Klf12_Klf14_Sp4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 8.8 | GO:0034031 | coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356) |
| 0.1 | 7.4 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.5 | 5.5 | GO:0006707 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.4 | 5.4 | GO:0034626 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.6 | 5.1 | GO:0045541 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
| 0.3 | 5.0 | GO:0071257 | cellular response to electrical stimulus(GO:0071257) |
| 0.1 | 4.5 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.7 | 4.3 | GO:0051790 | acetate metabolic process(GO:0006083) short-chain fatty acid biosynthetic process(GO:0051790) |
| 0.1 | 4.3 | GO:0050482 | arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963) |
| 0.5 | 4.1 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 46.9 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 23.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 12.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 10.3 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.5 | 7.9 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.1 | 7.8 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 5.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 4.8 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 4.7 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.1 | 4.5 | GO:0005801 | cis-Golgi network(GO:0005801) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 8.8 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 0.1 | 5.9 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.4 | 5.4 | GO:0102336 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 1.6 | 4.9 | GO:0003979 | UDP-glucose 6-dehydrogenase activity(GO:0003979) |
| 0.1 | 4.8 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.9 | 4.7 | GO:0070404 | NADH binding(GO:0070404) |
| 0.3 | 4.7 | GO:0015643 | toxic substance binding(GO:0015643) |
| 1.4 | 4.3 | GO:0003987 | acetate-CoA ligase activity(GO:0003987) |
| 0.1 | 4.2 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 0.8 | 4.0 | GO:0004142 | diacylglycerol cholinephosphotransferase activity(GO:0004142) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.3 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 5.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 4.6 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.1 | 3.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 3.4 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 3.3 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 3.1 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 2.8 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 2.7 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.1 | 2.3 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.9 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 7.9 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.4 | 5.8 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.0 | 5.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.4 | 5.7 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 5.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.3 | 5.1 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 5.1 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 4.9 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.8 | 4.8 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |