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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Jun
Z-value: 2.12
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Transcription factors associated with Jun
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Jun | mm10_v2_chr4_-_95052188_95052222 | 0.09 | 5.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_65968483 Show fit | 14.77 |
ENSMUST00000022616.6
|
clusterin |
|
| chr9_-_86695897 Show fit | 9.71 |
ENSMUST00000034989.8
|
malic enzyme 1, NADP(+)-dependent, cytosolic |
|
| chr1_+_182564994 Show fit | 9.64 |
ENSMUST00000048941.7
ENSMUST00000168514.1 |
calpain 8 |
|
| chr7_-_141276729 Show fit | 9.58 |
ENSMUST00000167263.1
ENSMUST00000080654.5 |
cadherin-related family member 5 |
|
| chr4_+_63356152 Show fit | 7.97 |
ENSMUST00000006687.4
|
orosomucoid 3 |
|
| chr8_-_5105232 Show fit | 7.60 |
ENSMUST00000023835.1
|
solute carrier family 10, member 2 |
|
| chr5_-_87254804 Show fit | 7.40 |
ENSMUST00000075858.3
|
UDP glucuronosyltransferase 2 family, polypeptide B37 |
|
| chr9_+_86695542 Show fit | 6.67 |
ENSMUST00000150367.2
|
RIKEN cDNA A330041J22 gene |
|
| chr10_+_128933782 Show fit | 6.57 |
ENSMUST00000099112.2
|
integrin alpha 7 |
|
| chr1_-_180193475 Show fit | 6.44 |
ENSMUST00000160482.1
ENSMUST00000170472.1 |
aarF domain containing kinase 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Jun
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.0 | GO:0043434 | response to peptide hormone(GO:0043434) |
| 2.5 | 14.8 | GO:1902998 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.5 | 14.0 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 1.8 | 12.7 | GO:0070495 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 1.4 | 9.7 | GO:0006108 | malate metabolic process(GO:0006108) regulation of NADP metabolic process(GO:1902031) |
| 1.9 | 9.6 | GO:1904970 | brush border assembly(GO:1904970) |
| 1.1 | 7.6 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.3 | 7.6 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 2.1 | 6.4 | GO:1990166 | protein localization to site of double-strand break(GO:1990166) |
| 2.1 | 6.4 | GO:0001983 | baroreceptor response to increased systemic arterial blood pressure(GO:0001983) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 14.8 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.0 | 12.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 11.0 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 10.8 | GO:0000502 | proteasome complex(GO:0000502) |
| 1.0 | 9.6 | GO:0089717 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 0.5 | 8.5 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.1 | 8.0 | GO:0005811 | lipid particle(GO:0005811) |
| 0.9 | 6.6 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.1 | 6.4 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 6.4 | GO:0030315 | T-tubule(GO:0030315) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 38.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.6 | 14.8 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 3.2 | 12.7 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 0.1 | 11.4 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.4 | 10.9 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 3.2 | 9.7 | GO:0004471 | malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) |
| 0.0 | 9.4 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 8.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.3 | 7.7 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 1.1 | 7.6 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.8 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.3 | 14.7 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.2 | 13.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 11.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 7.5 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 4.6 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.2 | 4.5 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 4.5 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.2 | 4.1 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 2.9 | PID CONE PATHWAY | Visual signal transduction: Cones |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.4 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.1 | 9.5 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 9.1 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.6 | 8.4 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.8 | 7.6 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.2 | 6.8 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.1 | 6.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 1.1 | 6.3 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.2 | 5.8 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.5 | 5.3 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |