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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 1.87

Motif logo

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7

Gene Symbol Gene ID Gene Info
ENSMUSG00000031627.7 interferon regulatory factor 2
ENSMUSG00000018899.10 interferon regulatory factor 1
ENSMUSG00000041515.3 interferon regulatory factor 8
ENSMUSG00000002325.8 interferon regulatory factor 9
ENSMUSG00000025498.8 interferon regulatory factor 7

Activity-expression correlation:

Activity profile of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Sorted Z-values of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_77729091 33.28 ENSMUST00000109775.2
apolipoprotein L 9b
chr1_+_130826676 19.85 ENSMUST00000027675.7
polymeric immunoglobulin receptor
chr1_+_130826762 18.74 ENSMUST00000133792.1
polymeric immunoglobulin receptor
chr15_-_77411034 17.58 ENSMUST00000089452.5
ENSMUST00000081776.3
apolipoprotein L 9a
chr2_-_173218879 16.47 ENSMUST00000109116.2
ENSMUST00000029018.7
Z-DNA binding protein 1
chr4_+_42629719 14.27 ENSMUST00000166898.2
predicted gene 2564
chr8_-_71537402 13.78 ENSMUST00000051672.7
bone marrow stromal cell antigen 2
chr19_+_34607927 13.35 ENSMUST00000076249.5
RIKEN cDNA I830012O16 gene
chr8_-_45333189 12.55 ENSMUST00000095328.4
cytochrome P450, family 4, subfamily v, polypeptide 3
chr19_+_34640871 12.19 ENSMUST00000102824.3
interferon-induced protein with tetratricopeptide repeats 1
chr18_+_60212080 12.06 ENSMUST00000031549.5
predicted gene 4951
chr2_+_122147680 11.55 ENSMUST00000102476.4
beta-2 microglobulin
chr19_-_11050500 11.53 ENSMUST00000099676.4
expressed sequence AW112010
chr5_-_105239533 11.52 ENSMUST00000065588.6
guanylate-binding protein 10
chr11_+_70459940 10.96 ENSMUST00000147289.1
ENSMUST00000126105.1
zinc finger, MYND-type containing 15
chr11_+_70459611 10.76 ENSMUST00000039093.3
zinc finger, MYND-type containing 15
chr7_-_141010759 10.64 ENSMUST00000026565.6
interferon induced transmembrane protein 3
chr11_+_49087022 10.50 ENSMUST00000046704.6
interferon gamma inducible protein 47
chr1_-_162984519 10.16 ENSMUST00000028010.7
flavin containing monooxygenase 3
chr3_-_151749877 9.57 ENSMUST00000029671.7
interferon-induced protein 44
chr19_+_34583528 9.53 ENSMUST00000102825.3
interferon-induced protein with tetratricopeptide repeats 3
chr16_+_43363855 9.38 ENSMUST00000156367.1
zinc finger and BTB domain containing 20
chr10_+_40629987 9.22 ENSMUST00000019977.7
D-aspartate oxidase
chr16_+_23609895 8.61 ENSMUST00000038423.5
receptor transporter protein 4
chr8_-_84773381 8.45 ENSMUST00000109764.1
nuclear factor I/X
chr3_-_113574758 8.44 ENSMUST00000106540.1
amylase 1, salivary
chr3_-_113574242 8.28 ENSMUST00000142505.2
amylase 1, salivary
chr7_-_141266415 8.27 ENSMUST00000106023.1
ENSMUST00000097952.2
ENSMUST00000026571.4
interferon regulatory factor 7
chr12_+_103434211 8.11 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
interferon, alpha-inducible protein 27
chr11_-_53859187 8.09 ENSMUST00000117316.1
ENSMUST00000120776.1
ENSMUST00000121435.1
predicted gene 12216
chr11_-_49064202 8.00 ENSMUST00000046745.6
T cell specific GTPase 2
chr11_-_48992226 7.97 ENSMUST00000059930.2
ENSMUST00000068063.3
predicted gene 12185
T cell specific GTPase 1
chr2_+_102706356 7.86 ENSMUST00000123759.1
ENSMUST00000111212.1
ENSMUST00000005220.4
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr7_-_14446570 7.85 ENSMUST00000063509.4
RIKEN cDNA 2810007J24 gene
chr15_-_77596110 7.77 ENSMUST00000089465.4
apolipoprotein L 10B
chr15_-_77533312 7.74 ENSMUST00000062562.5
apolipoprotein L 7c
chr9_+_20868628 7.64 ENSMUST00000043911.7
RIKEN cDNA A230050P20 gene
chr7_-_14446651 7.58 ENSMUST00000125941.1
RIKEN cDNA 2810007J24 gene
chr1_+_52119438 7.54 ENSMUST00000070968.7
signal transducer and activator of transcription 1
chr17_-_36042690 7.44 ENSMUST00000058801.8
ENSMUST00000080015.5
ENSMUST00000077960.6
histocompatibility 2, T region locus 22
chr9_-_106476104 7.43 ENSMUST00000156426.1
poly (ADP-ribose) polymerase family, member 3
chr9_-_106476372 7.40 ENSMUST00000123555.1
ENSMUST00000125850.1
poly (ADP-ribose) polymerase family, member 3
chr17_-_34187219 7.36 ENSMUST00000173831.1
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr3_+_142620596 7.28 ENSMUST00000165774.1
guanylate binding protein 2
chr18_+_60376029 7.18 ENSMUST00000066912.5
ENSMUST00000032473.6
interferon inducible GTPase 1
chr9_-_106476590 7.15 ENSMUST00000112479.2
poly (ADP-ribose) polymerase family, member 3
chr1_-_173599074 7.13 ENSMUST00000150649.1
ENSMUST00000180215.1
ENSMUST00000097462.2
pyrin domain containing 4
chr1_+_167618246 7.03 ENSMUST00000111380.1
retinoid X receptor gamma
chr4_-_42756543 6.88 ENSMUST00000102957.3
chemokine (C-C motif) ligand 19
chr9_+_77921908 6.45 ENSMUST00000133757.1
ELOVL family member 5, elongation of long chain fatty acids (yeast)
chr16_+_97536079 6.44 ENSMUST00000024112.7
myxovirus (influenza virus) resistance 2
chr17_-_34862122 6.41 ENSMUST00000154526.1
complement factor B
chr11_-_48871408 6.36 ENSMUST00000097271.2
immunity-related GTPase family M member 1
chr5_+_114923234 6.34 ENSMUST00000031540.4
ENSMUST00000112143.3
2'-5' oligoadenylate synthetase-like 1
chr6_-_23839137 6.32 ENSMUST00000166458.2
ENSMUST00000142913.2
ENSMUST00000115357.1
ENSMUST00000069074.7
ENSMUST00000115361.2
ENSMUST00000018122.7
ENSMUST00000115355.1
ENSMUST00000115356.2
Ca2+-dependent activator protein for secretion 2
chr11_-_48871344 6.30 ENSMUST00000049519.3
immunity-related GTPase family M member 1
chr6_-_39118211 6.22 ENSMUST00000038398.6
poly (ADP-ribose) polymerase family, member 12
chr4_-_42773993 6.19 ENSMUST00000095114.4
chemokine (C-C motif) ligand 21A (serine)
chr11_-_70459957 6.16 ENSMUST00000019064.2
chemokine (C-X-C motif) ligand 16
chr1_+_175631996 6.00 ENSMUST00000040250.8
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chrX_+_59999436 6.00 ENSMUST00000033477.4
coagulation factor IX
chr11_+_72301613 5.99 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
XIAP associated factor 1
chr1_-_150466165 5.99 ENSMUST00000162367.1
ENSMUST00000161611.1
ENSMUST00000161320.1
ENSMUST00000159035.1
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
chr11_+_119393060 5.94 ENSMUST00000131035.2
ENSMUST00000093902.5
ring finger protein 213
chr3_+_142560052 5.90 ENSMUST00000106222.2
guanylate binding protein 3
chr1_+_175632169 5.89 ENSMUST00000097458.3
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr1_+_173673651 5.86 ENSMUST00000085876.4
pyrin domain containing 3
chr17_+_36121666 5.67 ENSMUST00000173128.1
predicted gene, 19684
chr4_+_42255767 5.66 ENSMUST00000178864.1
chemokine (C-C motif) ligand 21B (leucine)
chr6_-_23839420 5.58 ENSMUST00000115358.2
ENSMUST00000163871.2
Ca2+-dependent activator protein for secretion 2
chr17_-_34862473 5.57 ENSMUST00000025229.4
ENSMUST00000176203.2
ENSMUST00000128767.1
complement factor B
chr4_-_40239779 5.51 ENSMUST00000037907.6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_-_51972990 5.48 ENSMUST00000145481.1
ENSMUST00000112705.2
N-myc (and STAT) interactor
chr3_+_142560351 5.44 ENSMUST00000106221.1
guanylate binding protein 3
chr5_-_105293699 5.41 ENSMUST00000050011.8
guanylate binding protein 6
chr3_+_142560108 5.41 ENSMUST00000128609.1
ENSMUST00000029935.7
guanylate binding protein 3
chr6_+_121245903 5.39 ENSMUST00000032198.9
ubiquitin specific peptidase 18
chr7_+_51878967 5.34 ENSMUST00000051912.6
growth arrest specific 2
chr17_+_34187545 5.31 ENSMUST00000170086.1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr2_-_126933229 5.25 ENSMUST00000028844.4
signal peptide peptidase like 2A
chr8_+_61928081 5.22 ENSMUST00000154398.1
ENSMUST00000093485.2
ENSMUST00000156980.1
ENSMUST00000070631.7
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr11_+_58199556 5.09 ENSMUST00000035266.4
ENSMUST00000094169.4
ENSMUST00000168280.1
ENSMUST00000058704.8
interferon gamma induced GTPase
immunity-related GTPase family M member 2
chr17_+_34187789 5.09 ENSMUST00000041633.8
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr7_+_51879041 4.91 ENSMUST00000107591.2
growth arrest specific 2
chr1_+_156035705 4.87 ENSMUST00000111754.2
ENSMUST00000133152.1
torsin A interacting protein 2
chr19_+_56397100 4.85 ENSMUST00000026062.9
caspase 7
chr2_-_77170534 4.81 ENSMUST00000111833.2
coiled-coil domain containing 141
chr11_-_100704217 4.76 ENSMUST00000017974.6
DEXH (Asp-Glu-X-His) box polypeptide 58
chr2_-_62646146 4.75 ENSMUST00000112459.3
ENSMUST00000028259.5
interferon induced with helicase C domain 1
chr16_+_43364145 4.73 ENSMUST00000148775.1
zinc finger and BTB domain containing 20
chr6_+_128662379 4.61 ENSMUST00000032518.4
C-type lectin domain family 2, member h
chr3_+_60081861 4.60 ENSMUST00000029326.5
succinate receptor 1
chr6_+_57580992 4.60 ENSMUST00000031817.8
hect domain and RLD 6
chr4_+_41903610 4.58 ENSMUST00000098128.3
predicted gene, 21541
chr4_+_42114817 4.57 ENSMUST00000098123.3
predicted gene 13304
chr16_+_35938470 4.56 ENSMUST00000114878.1
poly (ADP-ribose) polymerase family, member 9
chr15_+_99392882 4.56 ENSMUST00000023749.8
transmembrane BAX inhibitor motif containing 6
chr15_-_76243401 4.52 ENSMUST00000165738.1
ENSMUST00000075689.6
poly (ADP-ribose) polymerase family, member 10
chr7_+_119526269 4.51 ENSMUST00000066465.1
acyl-CoA synthetase medium-chain family member 5
chr6_-_85869128 4.45 ENSMUST00000045008.7
camello-like 2
chr18_-_60273267 4.44 ENSMUST00000090260.4
predicted gene 4841
chr18_-_61536522 4.43 ENSMUST00000171629.1
Rho guanine nucleotide exchange factor (GEF) 37
chr2_+_58755177 4.34 ENSMUST00000102755.3
uridine phosphorylase 2
chr13_+_4434306 4.29 ENSMUST00000021630.8
aldo-keto reductase family 1, member C6
chr17_-_34000257 4.29 ENSMUST00000087189.6
ENSMUST00000173075.1
ENSMUST00000172760.1
ENSMUST00000172912.1
ENSMUST00000025181.10
histocompatibility 2, K1, K region
chr13_+_4059565 4.26 ENSMUST00000041768.6
aldo-keto reductase family 1, member C14
chr16_-_24393588 4.21 ENSMUST00000181640.1
RIKEN cDNA 1110054M08 gene
chr2_+_58754910 4.21 ENSMUST00000059102.6
uridine phosphorylase 2
chr16_+_35938972 4.19 ENSMUST00000023622.6
ENSMUST00000114877.1
poly (ADP-ribose) polymerase family, member 9
chr3_+_142594847 4.10 ENSMUST00000029936.4
guanylate binding protein 2b
chr11_-_78984946 4.09 ENSMUST00000108268.3
lectin, galactose binding, soluble 9
chr3_-_98630309 4.02 ENSMUST00000044094.4
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
chr5_-_92348871 4.01 ENSMUST00000038816.6
ENSMUST00000118006.1
chemokine (C-X-C motif) ligand 10
chr17_+_33919332 3.99 ENSMUST00000025161.7
TAP binding protein
chr9_+_5345450 3.96 ENSMUST00000151332.1
caspase 12
chr1_-_153851189 3.94 ENSMUST00000059607.6
RIKEN cDNA 5830403L16 gene
chr4_-_46536096 3.94 ENSMUST00000102924.2
tripartite motif-containing 14
chr4_-_46536134 3.91 ENSMUST00000046897.6
tripartite motif-containing 14
chr1_-_173490933 3.90 ENSMUST00000160565.2
predicted gene 4955
chr9_+_5345414 3.88 ENSMUST00000027009.4
caspase 12
chr11_+_58215028 3.87 ENSMUST00000108836.1
immunity-related GTPase family M member 2
chr8_-_105938384 3.84 ENSMUST00000034369.8
proteasome (prosome, macropain) subunit, beta type 10
chr8_-_93279717 3.82 ENSMUST00000034178.8
carboxylesterase 1F
chr14_-_7994563 3.81 ENSMUST00000026315.7
deoxyribonuclease 1-like 3
chr18_-_3299537 3.75 ENSMUST00000129435.1
ENSMUST00000122958.1
cAMP responsive element modulator
chr10_-_34127955 3.69 ENSMUST00000062784.6
family with sequence similarity 26, member F
chr1_+_13668739 3.66 ENSMUST00000088542.3
X Kell blood group precursor related family member 9 homolog
chr17_+_37193889 3.64 ENSMUST00000038844.6
ubiquitin D
chr2_+_72054598 3.58 ENSMUST00000028525.5
Rap guanine nucleotide exchange factor (GEF) 4
chr6_-_31218421 3.58 ENSMUST00000115107.1
cDNA sequence AB041803
chr11_-_78984831 3.50 ENSMUST00000073001.4
ENSMUST00000108269.3
lectin, galactose binding, soluble 9
chr6_-_125231772 3.48 ENSMUST00000043422.7
TAP binding protein-like
chr13_-_23710714 3.46 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
hemochromatosis
chr1_-_172590463 3.44 ENSMUST00000065679.6
SLAM family member 8
chr6_+_34745952 3.41 ENSMUST00000123823.1
ENSMUST00000136907.1
ENSMUST00000126181.1
caldesmon 1
chr2_+_68117713 3.40 ENSMUST00000112346.2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr2_-_24049389 3.38 ENSMUST00000051416.5
histamine N-methyltransferase
chr7_+_104244449 3.38 ENSMUST00000106849.2
ENSMUST00000060315.5
tripartite motif-containing 34A
chr17_+_35439155 3.37 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
histocompatibility 2, Q region locus 7
chr5_+_67260794 3.29 ENSMUST00000161369.1
transmembrane protein 33
chr8_+_70083509 3.24 ENSMUST00000007738.9
hyaluronan and proteoglycan link protein 4
chr1_+_156035392 3.21 ENSMUST00000111757.3
torsin A interacting protein 2
chr7_+_104244465 3.21 ENSMUST00000106848.1
tripartite motif-containing 34A
chr2_-_51973219 3.19 ENSMUST00000028314.2
N-myc (and STAT) interactor
chr15_+_75862310 3.18 ENSMUST00000023238.4
gasdermin D
chr16_-_35939082 3.18 ENSMUST00000081933.7
ENSMUST00000114885.1
deltex 3-like (Drosophila)
chr13_+_51846673 3.11 ENSMUST00000021903.2
growth arrest and DNA-damage-inducible 45 gamma
chr7_+_107567445 3.11 ENSMUST00000120990.1
olfactomedin-like 1
chr7_+_104244496 3.05 ENSMUST00000106854.1
ENSMUST00000143414.1
tripartite motif-containing 34A
chr3_+_27317028 2.96 ENSMUST00000046383.5
ENSMUST00000174840.1
tumor necrosis factor (ligand) superfamily, member 10
chr3_+_142530329 2.94 ENSMUST00000171263.1
ENSMUST00000045097.9
guanylate binding protein 7
chr15_-_76014318 2.91 ENSMUST00000060807.5
family with sequence similarity 83, member H
chr6_+_124512615 2.90 ENSMUST00000068593.7
complement component 1, r subcomponent A
chr13_+_33004528 2.90 ENSMUST00000006391.4
serine (or cysteine) peptidase inhibitor, clade B, member 9
chr3_+_81932601 2.83 ENSMUST00000029649.2
cathepsin O
chr4_+_135728116 2.83 ENSMUST00000102546.3
interleukin 22 receptor, alpha 1
chr5_-_105139539 2.81 ENSMUST00000100961.4
ENSMUST00000031235.6
ENSMUST00000100962.3
guanylate-binding protein 9
guanylate-binding protein 8
guanylate binding protein 4
chr18_-_3299452 2.81 ENSMUST00000126578.1
cAMP responsive element modulator
chr1_-_155146755 2.80 ENSMUST00000027744.8
major histocompatibility complex, class I-related
chr13_+_74639866 2.76 ENSMUST00000169114.1
endoplasmic reticulum aminopeptidase 1
chr12_+_37241633 2.75 ENSMUST00000049874.7
alkylglycerol monooxygenase
chr5_-_105110292 2.74 ENSMUST00000031238.6
guanylate-binding protein 9
chr2_+_43555321 2.70 ENSMUST00000028223.2
kynureninase (L-kynurenine hydrolase)
chr4_-_40239700 2.69 ENSMUST00000142055.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr6_-_38354243 2.68 ENSMUST00000114900.1
zinc finger CCCH type, antiviral 1
chr19_-_7966000 2.68 ENSMUST00000182102.1
ENSMUST00000075619.4
solute carrier family 22, member 27
chr12_+_37241729 2.67 ENSMUST00000160768.1
alkylglycerol monooxygenase
chr18_+_60293372 2.66 ENSMUST00000171297.1
RIKEN cDNA F830016B08 gene
chr15_-_76307101 2.66 ENSMUST00000171340.1
5-oxoprolinase (ATP-hydrolysing)
chr5_-_91402905 2.64 ENSMUST00000121044.2
betacellulin, epidermal growth factor family member
chr3_-_86999284 2.64 ENSMUST00000063869.5
ENSMUST00000029717.2
CD1d1 antigen
chr16_+_26581704 2.63 ENSMUST00000096129.2
ENSMUST00000166294.2
ENSMUST00000174202.1
ENSMUST00000023156.6
interleukin 1 receptor accessory protein
chr3_+_142496924 2.61 ENSMUST00000090127.2
guanylate binding protein 5
chr9_-_50555170 2.60 ENSMUST00000119103.1
beta-carotene oxygenase 2
chr10_+_39612934 2.59 ENSMUST00000019987.6
TRAF3 interacting protein 2
chr8_-_3748941 2.58 ENSMUST00000012847.1
CD209a antigen
chr2_+_43555342 2.57 ENSMUST00000112826.1
ENSMUST00000050511.6
kynureninase (L-kynurenine hydrolase)
chr1_+_130865669 2.57 ENSMUST00000038829.5
Fas apoptotic inhibitory molecule 3
chr2_-_126783416 2.57 ENSMUST00000130356.1
ENSMUST00000028842.2
ubiquitin specific peptidase 50
chr2_+_27676440 2.55 ENSMUST00000129514.1
retinoid X receptor alpha
chr17_+_35262730 2.55 ENSMUST00000172785.1
histocompatibility 2, D region locus 1
chr17_+_35470083 2.51 ENSMUST00000174525.1
ENSMUST00000068291.6
histocompatibility 2, Q region locus 10
chr12_+_37242030 2.50 ENSMUST00000160390.1
alkylglycerol monooxygenase
chr6_-_54972603 2.49 ENSMUST00000060655.8
nucleotide-binding oligomerization domain containing 1
chr8_-_111338152 2.46 ENSMUST00000056157.7
ENSMUST00000120432.1
mixed lineage kinase domain-like
chr14_+_41105359 2.46 ENSMUST00000047286.6
methionine adenosyltransferase I, alpha
chr10_-_92375367 2.40 ENSMUST00000182870.1
predicted gene, 20757
chr19_+_8898090 2.39 ENSMUST00000096246.3
alpha glucosidase 2 alpha neutral subunit
chr17_+_31433054 2.37 ENSMUST00000136384.1
phosphodiesterase 9A
chr8_-_3878549 2.36 ENSMUST00000011445.6
CD209d antigen
chr10_+_128270546 2.34 ENSMUST00000105238.3
ENSMUST00000085708.2
signal transducer and activator of transcription 2
chr8_-_84800024 2.34 ENSMUST00000126806.1
ENSMUST00000076715.6
nuclear factor I/X
chr19_-_24861828 2.34 ENSMUST00000047666.4
phosphoglucomutase 5
chr8_-_84800344 2.33 ENSMUST00000099070.3
nuclear factor I/X
chr4_+_155582476 2.32 ENSMUST00000105612.1
NAD kinase
chr2_-_77170592 2.32 ENSMUST00000164114.2
ENSMUST00000049544.7
coiled-coil domain containing 141
chr3_+_138313279 2.30 ENSMUST00000013455.6
ENSMUST00000106247.1
alcohol dehydrogenase 6A (class V)
chr10_+_4611971 2.29 ENSMUST00000105590.1
ENSMUST00000067086.7
estrogen receptor 1 (alpha)
chr19_-_21472552 2.28 ENSMUST00000087600.3
guanine deaminase
chr2_+_19371636 2.28 ENSMUST00000023856.8
methionine sulfoxide reductase B2

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.6 38.6 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
7.3 22.0 GO:1990166 protein localization to site of double-strand break(GO:1990166)
4.4 13.1 GO:2000547 regulation of dendritic cell dendrite assembly(GO:2000547)
3.5 3.5 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
3.5 41.6 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
3.3 10.0 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
3.1 176.4 GO:0035456 response to interferon-beta(GO:0035456)
3.1 9.2 GO:0006533 aspartate catabolic process(GO:0006533)
2.9 8.7 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
2.9 17.2 GO:0019805 quinolinate biosynthetic process(GO:0019805)
2.8 8.3 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
2.1 2.1 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
2.0 12.2 GO:0035549 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
2.0 10.0 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
1.9 17.1 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
1.8 9.0 GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
1.6 4.9 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
1.6 6.4 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
1.5 4.5 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
1.5 11.9 GO:1990504 dense core granule exocytosis(GO:1990504)
1.5 1.5 GO:0002488 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489)
1.4 4.3 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
1.3 5.3 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
1.3 3.8 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
1.1 3.4 GO:0019883 antigen processing and presentation of endogenous antigen(GO:0019883)
1.1 7.9 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.0 2.9 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.9 3.6 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.9 3.5 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.9 70.7 GO:0034341 response to interferon-gamma(GO:0034341)
0.8 2.5 GO:0018900 dichloromethane metabolic process(GO:0018900)
0.8 13.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.8 14.5 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.8 2.3 GO:0046098 guanine metabolic process(GO:0046098)
0.7 6.0 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.7 8.1 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.7 4.4 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.7 9.5 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.7 3.4 GO:1902623 leukocyte chemotaxis involved in inflammatory response(GO:0002232) negative regulation of neutrophil migration(GO:1902623)
0.7 2.0 GO:0071211 protein targeting to vacuole involved in autophagy(GO:0071211)
0.7 5.2 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.7 2.0 GO:0060809 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) mesodermal to mesenchymal transition involved in gastrulation(GO:0060809)
0.6 8.0 GO:0097264 self proteolysis(GO:0097264)
0.6 2.5 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.6 1.8 GO:0045013 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.6 1.1 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.6 2.3 GO:0030091 protein repair(GO:0030091)
0.6 1.7 GO:1903538 meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.6 1.7 GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.5 1.6 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.5 6.5 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.5 2.1 GO:0046351 disaccharide biosynthetic process(GO:0046351)
0.5 1.0 GO:0006714 sesquiterpenoid metabolic process(GO:0006714)
0.5 2.1 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.5 2.6 GO:0006447 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.5 8.0 GO:0046485 ether lipid metabolic process(GO:0046485)
0.5 1.5 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.5 3.4 GO:0052805 imidazole-containing compound catabolic process(GO:0052805)
0.5 9.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.5 1.4 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.4 0.4 GO:1990009 retinal cell apoptotic process(GO:1990009)
0.4 17.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.4 3.5 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.4 2.2 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.4 2.2 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.4 2.5 GO:0003383 apical constriction(GO:0003383)
0.4 11.5 GO:0035634 response to stilbenoid(GO:0035634)
0.4 1.2 GO:0032474 otolith morphogenesis(GO:0032474) otolith development(GO:0048840)
0.4 0.8 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production(GO:0071649)
0.4 2.3 GO:0006741 NADP biosynthetic process(GO:0006741)
0.4 0.8 GO:0071332 cellular response to fructose stimulus(GO:0071332)
0.4 1.1 GO:0048239 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.4 12.2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.4 2.3 GO:0060751 Sertoli cell proliferation(GO:0060011) prostate epithelial cord elongation(GO:0060523) epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) branch elongation involved in mammary gland duct branching(GO:0060751)
0.4 1.5 GO:0010901 negative regulation of cytokine secretion involved in immune response(GO:0002740) regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
0.4 1.5 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.4 3.8 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.4 10.2 GO:0017144 drug metabolic process(GO:0017144)
0.4 1.1 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.4 0.7 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.4 0.7 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.3 1.0 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.3 1.4 GO:0032385 positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373)
0.3 1.7 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.3 1.0 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.3 7.9 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.3 2.6 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.3 0.9 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.3 2.8 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.3 1.8 GO:0044375 regulation of peroxisome size(GO:0044375)
0.3 0.9 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.3 0.3 GO:2000836 positive regulation of androgen secretion(GO:2000836)
0.3 2.1 GO:0072086 specification of loop of Henle identity(GO:0072086)
0.3 2.6 GO:0072602 interleukin-4 secretion(GO:0072602)
0.3 2.0 GO:0051138 positive regulation of NK T cell differentiation(GO:0051138)
0.3 1.4 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.3 1.7 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.3 1.1 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.3 0.5 GO:0038086 VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091)
0.3 1.6 GO:0051204 protein insertion into mitochondrial membrane(GO:0051204)
0.3 1.3 GO:0045351 type I interferon biosynthetic process(GO:0045351)
0.3 1.6 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.3 2.6 GO:0035810 positive regulation of urine volume(GO:0035810)
0.3 1.6 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.3 0.8 GO:1905051 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.3 4.3 GO:0010623 programmed cell death involved in cell development(GO:0010623)
0.3 13.2 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.3 1.8 GO:0010990 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.3 7.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.2 2.2 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.2 2.2 GO:0032494 response to peptidoglycan(GO:0032494)
0.2 1.0 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.2 0.7 GO:0006553 lysine metabolic process(GO:0006553)
0.2 1.7 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.2 1.2 GO:0019348 dolichol metabolic process(GO:0019348)
0.2 0.7 GO:0060220 camera-type eye photoreceptor cell fate commitment(GO:0060220) negative regulation of neural retina development(GO:0061076) negative regulation of retina development in camera-type eye(GO:1902867) negative regulation of amacrine cell differentiation(GO:1902870)
0.2 0.2 GO:0018307 enzyme active site formation(GO:0018307)
0.2 0.7 GO:1901026 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.2 1.4 GO:0036112 medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.2 2.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 0.2 GO:2000793 cell proliferation involved in heart valve development(GO:2000793)
0.2 0.4 GO:0071316 cellular response to nicotine(GO:0071316)
0.2 1.2 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.2 1.2 GO:0015889 cobalamin transport(GO:0015889)
0.2 0.4 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.2 1.5 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.2 0.2 GO:2000911 positive regulation of cholesterol import(GO:1904109) positive regulation of sterol import(GO:2000911)
0.2 0.9 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.2 0.4 GO:0070933 histone H4 deacetylation(GO:0070933)
0.2 1.7 GO:0071763 nuclear membrane organization(GO:0071763)
0.2 1.8 GO:0014029 neural crest formation(GO:0014029)
0.2 1.8 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.2 1.4 GO:0097475 motor neuron migration(GO:0097475)
0.2 1.8 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.2 1.1 GO:0033227 dsRNA transport(GO:0033227)
0.2 0.5 GO:0045348 positive regulation of MHC class II biosynthetic process(GO:0045348)
0.2 0.7 GO:0006624 vacuolar protein processing(GO:0006624)
0.2 0.9 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.2 0.7 GO:0034769 basement membrane disassembly(GO:0034769)
0.2 0.7 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.2 0.8 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.2 3.0 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.2 2.5 GO:2000778 positive regulation of interleukin-6 secretion(GO:2000778)
0.2 0.8 GO:0098886 modification of dendritic spine(GO:0098886)
0.2 0.3 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.2 0.5 GO:0051030 RNA import into nucleus(GO:0006404) snRNA transport(GO:0051030)
0.2 7.8 GO:0019882 antigen processing and presentation(GO:0019882)
0.2 0.5 GO:1902966 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.2 2.4 GO:0033327 Leydig cell differentiation(GO:0033327)
0.2 0.5 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.2 0.5 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.2 0.6 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853)
0.2 0.8 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.2 2.1 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.1 1.9 GO:0032836 glomerular basement membrane development(GO:0032836)
0.1 1.5 GO:0021678 third ventricle development(GO:0021678)
0.1 0.9 GO:1901317 regulation of sperm motility(GO:1901317)
0.1 1.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 1.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 2.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 5.5 GO:0051642 centrosome localization(GO:0051642)
0.1 1.1 GO:0035902 response to immobilization stress(GO:0035902)
0.1 1.9 GO:0019321 pentose metabolic process(GO:0019321)
0.1 4.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 1.6 GO:0070932 histone H3 deacetylation(GO:0070932)
0.1 1.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 0.4 GO:0071288 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) cellular response to mercury ion(GO:0071288)
0.1 2.4 GO:0006491 N-glycan processing(GO:0006491)
0.1 1.3 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 1.6 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 0.4 GO:0003360 brainstem development(GO:0003360)
0.1 0.5 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.1 1.9 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 3.0 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 1.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 1.0 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 15.3 GO:0019395 fatty acid oxidation(GO:0019395)
0.1 0.5 GO:1900019 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.1 2.6 GO:0061462 protein localization to lysosome(GO:0061462)
0.1 1.5 GO:0009143 nucleoside triphosphate catabolic process(GO:0009143)
0.1 4.3 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1 0.8 GO:0060613 fat pad development(GO:0060613)
0.1 2.2 GO:0046931 pore complex assembly(GO:0046931)
0.1 1.3 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.1 4.5 GO:0070207 protein homotrimerization(GO:0070207)
0.1 1.4 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 19.0 GO:0007286 spermatid development(GO:0007286)
0.1 1.0 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.3 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 1.2 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.1 0.7 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 0.7 GO:0039019 pronephric nephron development(GO:0039019)
0.1 0.3 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.1 1.5 GO:0015747 urate transport(GO:0015747)
0.1 0.7 GO:0007296 vitellogenesis(GO:0007296)
0.1 0.7 GO:0016266 O-glycan processing(GO:0016266)
0.1 0.7 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1 0.4 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 1.7 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.8 GO:0048245 mast cell chemotaxis(GO:0002551) eosinophil chemotaxis(GO:0048245)
0.1 0.8 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1 0.7 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.1 0.5 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.1 0.3 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.1 0.5 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 0.8 GO:0033133 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.1 0.5 GO:0060763 mammary duct terminal end bud growth(GO:0060763)
0.1 0.5 GO:0060278 regulation of ovulation(GO:0060278)
0.1 0.8 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.1 0.8 GO:0034116 positive regulation of heterotypic cell-cell adhesion(GO:0034116)
0.1 1.0 GO:0031953 negative regulation of protein autophosphorylation(GO:0031953)
0.1 2.1 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 1.9 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 0.6 GO:0006983 ER overload response(GO:0006983)
0.1 1.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.3 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.1 10.8 GO:0016052 carbohydrate catabolic process(GO:0016052)
0.1 1.4 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.6 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.1 1.2 GO:0072189 ureter development(GO:0072189)
0.1 0.4 GO:0090168 Golgi reassembly(GO:0090168)
0.1 1.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.2 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.1 0.9 GO:0061318 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1 0.4 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.1 0.5 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.7 GO:0007343 egg activation(GO:0007343)
0.1 0.4 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.2 GO:0021852 pyramidal neuron migration(GO:0021852)
0.1 0.5 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 1.0 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.1 1.3 GO:0051923 sulfation(GO:0051923)
0.1 0.6 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 2.8 GO:0044380 protein localization to cytoskeleton(GO:0044380)
0.1 1.1 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 0.2 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.1 0.7 GO:0006450 regulation of translational fidelity(GO:0006450)
0.1 0.6 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.1 0.7 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.1 3.0 GO:0006695 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.1 4.5 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.1 0.9 GO:0008298 intracellular mRNA localization(GO:0008298)
0.1 0.4 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.1 0.7 GO:1990403 embryonic brain development(GO:1990403)
0.1 0.4 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 0.6 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996) regulation of establishment of protein localization to plasma membrane(GO:0090003)
0.1 0.9 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.1 0.6 GO:0009062 fatty acid catabolic process(GO:0009062)
0.1 1.2 GO:0015813 L-glutamate transport(GO:0015813)
0.1 2.4 GO:0010390 histone monoubiquitination(GO:0010390)
0.1 1.6 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1 0.1 GO:0060025 regulation of synaptic activity(GO:0060025)
0.1 0.7 GO:1902170 cellular response to reactive nitrogen species(GO:1902170)
0.1 2.2 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.1 0.3 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 0.8 GO:0043248 proteasome assembly(GO:0043248)
0.1 0.1 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.1 0.1 GO:0000960 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.1 0.5 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.1 0.4 GO:0015808 L-alanine transport(GO:0015808)
0.1 1.0 GO:0032689 negative regulation of interferon-gamma production(GO:0032689)
0.1 0.2 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0 0.4 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.3 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.0 0.5 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.9 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.5 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 0.3 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.0 0.4 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.2 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.0 0.8 GO:0002360 T cell lineage commitment(GO:0002360)
0.0 0.2 GO:1903999 regulation of eating behavior(GO:1903998) negative regulation of eating behavior(GO:1903999) regulation of defecation(GO:2000292) negative regulation of defecation(GO:2000293)
0.0 0.9 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 1.1 GO:0007635 chemosensory behavior(GO:0007635)
0.0 0.3 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.0 0.2 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.0 0.5 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.3 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 3.0 GO:0030193 regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.0 0.4 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 1.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.2 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 5.8 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.1 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.0 1.0 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.0 3.4 GO:0032092 positive regulation of protein binding(GO:0032092)
0.0 0.4 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.3 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 2.0 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.3 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.5 GO:1903541 regulation of exosomal secretion(GO:1903541) positive regulation of exosomal secretion(GO:1903543)
0.0 0.6 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.8 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.2 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.0 0.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.8 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.9 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 1.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 2.3 GO:0006006 glucose metabolic process(GO:0006006)
0.0 0.1 GO:0021623 oculomotor nerve morphogenesis(GO:0021622) oculomotor nerve formation(GO:0021623)
0.0 0.6 GO:0007143 female meiotic division(GO:0007143)
0.0 1.0 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.0 0.0 GO:0046881 positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0 0.4 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.7 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 1.1 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 0.9 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.0 0.1 GO:0051096 regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096)
0.0 0.2 GO:0009214 cyclic nucleotide catabolic process(GO:0009214)
0.0 6.1 GO:0009116 nucleoside metabolic process(GO:0009116)
0.0 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.2 GO:0010452 histone H3-K36 methylation(GO:0010452)
0.0 0.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.3 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.2 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.2 GO:1904219 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.2 GO:1902306 negative regulation of sodium ion transmembrane transport(GO:1902306) negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.2 GO:0045779 negative regulation of bone resorption(GO:0045779)
0.0 0.4 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0 0.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.6 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154) regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.0 0.2 GO:0046337 phosphatidylethanolamine metabolic process(GO:0046337)
0.0 0.3 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.1 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 1.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.2 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 0.0 GO:0090365 regulation of mRNA modification(GO:0090365)
0.0 0.2 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.0 GO:0006583 melanin biosynthetic process from tyrosine(GO:0006583)
0.0 0.3 GO:0009072 aromatic amino acid family metabolic process(GO:0009072)
0.0 0.1 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.1 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.0 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.2 GO:0006903 vesicle targeting(GO:0006903)
0.0 0.1 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) regulation of microvillus assembly(GO:0032534)
0.0 0.1 GO:0090272 negative regulation of fibroblast growth factor production(GO:0090272)
0.0 0.3 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.0 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.0 0.0 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 0.1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.1 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.3 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 58.2 GO:0020003 symbiont-containing vacuole(GO:0020003)
2.7 32.3 GO:0042612 MHC class I protein complex(GO:0042612)
2.2 11.2 GO:1990111 spermatoproteasome complex(GO:1990111)
2.1 17.0 GO:0042825 TAP complex(GO:0042825)
1.6 6.5 GO:0097447 dendritic tree(GO:0097447)
1.1 8.6 GO:0045098 type III intermediate filament(GO:0045098)
0.9 14.1 GO:0044754 autolysosome(GO:0044754)
0.9 38.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.9 5.2 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.9 7.8 GO:0030478 actin cap(GO:0030478)
0.7 3.6 GO:0044316 cone cell pedicle(GO:0044316)
0.6 1.1 GO:0030870 Mre11 complex(GO:0030870)
0.5 2.3 GO:0005914 spot adherens junction(GO:0005914)
0.4 2.6 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.4 3.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.4 1.2 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.4 17.0 GO:0035861 site of double-strand break(GO:0035861)
0.4 1.9 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.3 2.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.3 1.9 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.3 2.5 GO:0033269 internode region of axon(GO:0033269)
0.3 2.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.3 2.2 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.3 1.5 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.3 3.0 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.3 1.2 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.3 1.5 GO:0071986 Ragulator complex(GO:0071986)
0.3 0.8 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.3 1.0 GO:0043202 lysosomal lumen(GO:0043202)
0.2 2.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.2 23.0 GO:0042734 presynaptic membrane(GO:0042734)
0.2 0.7 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.2 0.7 GO:0000814 ESCRT II complex(GO:0000814)
0.2 0.9 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.2 6.8 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 2.1 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.2 1.2 GO:0045293 mRNA editing complex(GO:0045293)
0.2 3.6 GO:0016235 aggresome(GO:0016235)
0.2 1.4 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.2 2.4 GO:0042611 MHC protein complex(GO:0042611)
0.2 1.0 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.2 0.9 GO:0072487 MSL complex(GO:0072487)
0.2 0.8 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.2 1.2 GO:0070695 FHF complex(GO:0070695)
0.1 6.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.4 GO:0043512 inhibin A complex(GO:0043512)
0.1 1.2 GO:0005839 proteasome core complex(GO:0005839)
0.1 1.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 3.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 2.4 GO:0043186 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 1.0 GO:0000439 core TFIIH complex(GO:0000439)
0.1 0.4 GO:0044307 dendritic branch(GO:0044307)
0.1 1.2 GO:0005579 membrane attack complex(GO:0005579)
0.1 16.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 1.7 GO:0043196 varicosity(GO:0043196)
0.1 1.4 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 50.3 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 17.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.4 GO:0070110 ciliary neurotrophic factor receptor complex(GO:0070110) CNTFR-CLCF1 complex(GO:0097059)
0.1 3.0 GO:0045095 keratin filament(GO:0045095)
0.1 0.4 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.1 1.6 GO:0031527 filopodium membrane(GO:0031527)
0.1 0.3 GO:0071942 XPC complex(GO:0071942)
0.1 1.8 GO:0005922 connexon complex(GO:0005922)
0.1 0.5 GO:0051286 cell tip(GO:0051286)
0.1 0.2 GO:1990462 omegasome(GO:1990462)
0.1 0.4 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 5.5 GO:0005811 lipid particle(GO:0005811)
0.1 10.6 GO:0072562 blood microparticle(GO:0072562)
0.1 1.2 GO:0000124 SAGA complex(GO:0000124)
0.1 3.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 1.0 GO:0017119 Golgi transport complex(GO:0017119)
0.1 1.2 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.3 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.8 GO:0045179 apical cortex(GO:0045179)
0.1 1.4 GO:0033270 paranode region of axon(GO:0033270)
0.1 0.4 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.6 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 0.3 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.5 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 0.4 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 0.4 GO:0042587 glycogen granule(GO:0042587)
0.1 1.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 6.0 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 0.2 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 1.2 GO:0002080 acrosomal membrane(GO:0002080)
0.0 1.6 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.5 GO:0005642 annulate lamellae(GO:0005642)
0.0 20.4 GO:0045177 apical part of cell(GO:0045177)
0.0 0.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.0 2.1 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 5.6 GO:0005923 bicellular tight junction(GO:0005923)
0.0 6.4 GO:0005770 late endosome(GO:0005770)
0.0 0.7 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.9 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.4 GO:0031931 TORC1 complex(GO:0031931)
0.0 3.9 GO:0005604 basement membrane(GO:0005604)
0.0 2.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.7 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.2 GO:0097441 basilar dendrite(GO:0097441)
0.0 2.4 GO:0031301 integral component of organelle membrane(GO:0031301)
0.0 0.9 GO:0030175 filopodium(GO:0030175)
0.0 27.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.3 GO:0070069 cytochrome complex(GO:0070069)
0.0 1.6 GO:0030662 coated vesicle membrane(GO:0030662)
0.0 0.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.5 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)
0.0 3.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.3 GO:0036156 inner dynein arm(GO:0036156)
0.0 7.7 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 1.4 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 4.6 GO:0043235 receptor complex(GO:0043235)
0.0 2.6 GO:0000139 Golgi membrane(GO:0000139)
0.0 66.1 GO:0005829 cytosol(GO:0005829)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 0.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 26.7 GO:0005615 extracellular space(GO:0005615)
0.0 0.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 2.1 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.4 GO:0005902 microvillus(GO:0005902)
0.0 1.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.9 GO:0000922 spindle pole(GO:0000922)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0055037 recycling endosome(GO:0055037)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.5 GO:0003692 left-handed Z-DNA binding(GO:0003692)
3.9 39.0 GO:0019763 immunoglobulin receptor activity(GO:0019763)
2.6 7.9 GO:0050479 glyceryl-ether monooxygenase activity(GO:0050479)
2.4 22.0 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
2.4 17.0 GO:0046978 TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
2.4 16.7 GO:0004556 alpha-amylase activity(GO:0004556)
2.3 9.2 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
2.2 8.6 GO:0031849 olfactory receptor binding(GO:0031849)
2.0 24.0 GO:0030881 beta-2-microglobulin binding(GO:0030881)
2.0 11.9 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
1.7 6.9 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
1.7 8.6 GO:0004850 uridine phosphorylase activity(GO:0004850)
1.7 10.0 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
1.4 4.3 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
1.4 4.3 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
1.4 4.1 GO:0019002 GMP binding(GO:0019002)
1.3 5.3 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
1.3 7.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.1 7.6 GO:0016936 galactoside binding(GO:0016936)
1.1 4.3 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
1.0 38.3 GO:0008009 chemokine activity(GO:0008009)
1.0 10.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
1.0 10.8 GO:0050700 CARD domain binding(GO:0050700)
1.0 9.6 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.9 7.5 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.9 13.9 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.9 13.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.9 4.4 GO:0004883 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.9 1.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.8 3.4 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.8 2.5 GO:0047651 hydrolase activity, acting on acid halide bonds(GO:0016824) hydrolase activity, acting on acid halide bonds, in C-halide compounds(GO:0019120) alkylhalidase activity(GO:0047651)
0.8 2.5 GO:0042015 interleukin-20 binding(GO:0042015)
0.8 18.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.8 2.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.7 2.0 GO:0004658 propionyl-CoA carboxylase activity(GO:0004658)
0.7 7.4 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.7 2.6 GO:0002114 interleukin-33 receptor activity(GO:0002114)
0.7 5.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.6 1.9 GO:0019150 D-ribulokinase activity(GO:0019150)
0.6 1.9 GO:0005118 sevenless binding(GO:0005118)
0.6 4.5 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.6 15.4 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.6 2.9 GO:1990254 keratin filament binding(GO:1990254)
0.5 2.2 GO:0071614 linoleic acid epoxygenase activity(GO:0071614)
0.5 6.5 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.5 1.5 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
0.5 1.5 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211)
0.5 3.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.4 2.2 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.4 8.9 GO:0042605 peptide antigen binding(GO:0042605)
0.4 0.8 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.4 2.3 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.4 2.7 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.4 1.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.4 3.2 GO:1901612 cardiolipin binding(GO:1901612)
0.3 1.0 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.3 1.4 GO:1904121 propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121)
0.3 1.4 GO:0016508 long-chain-enoyl-CoA hydratase activity(GO:0016508)
0.3 2.8 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.3 5.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.3 2.4 GO:0015288 porin activity(GO:0015288)
0.3 2.0 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.3 2.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.3 1.3 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.3 2.8 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.3 8.1 GO:0005521 lamin binding(GO:0005521)
0.3 2.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 1.2 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.3 4.0 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.3 2.3 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.3 92.1 GO:0003924 GTPase activity(GO:0003924)
0.3 0.8 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.3 2.0 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.3 8.3 GO:0001671 ATPase activator activity(GO:0001671)
0.3 7.4 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.3 4.5 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.3 1.0 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.2 1.0 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.2 0.7 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.2 4.7 GO:0005537 mannose binding(GO:0005537)
0.2 1.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 0.9 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.2 0.9 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.2 1.7 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.2 4.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2 1.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.2 2.9 GO:0019203 carbohydrate phosphatase activity(GO:0019203) sugar-phosphatase activity(GO:0050308)
0.2 5.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 0.6 GO:0005110 frizzled-2 binding(GO:0005110)
0.2 1.2 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.2 3.6 GO:0070628 proteasome binding(GO:0070628)
0.2 0.6 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.2 16.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 0.4 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.2 0.8 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.2 0.7 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.2 1.3 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.2 0.5 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.2 0.5 GO:0070052 collagen V binding(GO:0070052)
0.2 2.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 1.1 GO:0032557 pyrimidine ribonucleotide binding(GO:0032557)
0.1 0.7 GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761)
0.1 2.4 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 1.0 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 3.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.4 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302)
0.1 1.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 0.5 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 0.5 GO:0061513 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.1 1.2 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.5 GO:0008147 structural constituent of bone(GO:0008147)
0.1 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 0.4 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 1.9 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.6 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 15.3 GO:0004497 monooxygenase activity(GO:0004497)
0.1 0.6 GO:0034584 piRNA binding(GO:0034584)
0.1 1.6 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 0.5 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.1 0.5 GO:0004974 leukotriene receptor activity(GO:0004974)
0.1 2.3 GO:0003951 NAD+ kinase activity(GO:0003951)
0.1 0.4 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 18.7 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 1.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 1.7 GO:0051400 BH domain binding(GO:0051400)
0.1 1.8 GO:0017166 vinculin binding(GO:0017166)
0.1 0.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.4 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 1.6 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 0.7 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.1 0.7 GO:0001515 opioid peptide activity(GO:0001515)
0.1 1.5 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 0.4 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 0.5 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 2.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.2 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.1 1.0 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.1 0.6 GO:0034046 poly(G) binding(GO:0034046)
0.1 4.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 4.2 GO:0030552 cAMP binding(GO:0030552)
0.1 1.1 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 4.0 GO:0030332 cyclin binding(GO:0030332)
0.1 0.7 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 2.1 GO:0071837 HMG box domain binding(GO:0071837)
0.1 2.3 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.8 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.2 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.1 0.6 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 0.3 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.1 2.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 2.1 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 13.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.9 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 0.3 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.1 0.4 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.2 GO:0008176 tRNA (guanine-N7-)-methyltransferase activity(GO:0008176)
0.1 0.4 GO:0045340 mercury ion binding(GO:0045340)
0.1 0.6 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.1 1.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 16.4 GO:0001047 core promoter binding(GO:0001047)
0.1 1.7 GO:0005542 folic acid binding(GO:0005542)
0.1 0.3 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 2.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.4 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.1 0.4 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 0.9 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 5.5 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 2.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 1.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.1 2.5 GO:0043531 ADP binding(GO:0043531)
0.1 3.4 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 0.2 GO:0004471 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) oxaloacetate decarboxylase activity(GO:0008948)
0.1 0.4 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 0.7 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.8 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.7 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 1.0 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.2 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 0.2 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.0 2.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.7 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.9 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 3.2 GO:0005518 collagen binding(GO:0005518)
0.0 0.2 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 1.0 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.7 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 3.5 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 1.2 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 2.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.4 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.2 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.5 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 2.0 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.2 GO:0005042 netrin receptor activity(GO:0005042)
0.0 1.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.8 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0031531 thyrotropin-releasing hormone receptor binding(GO:0031531)
0.0 0.2 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 0.2 GO:0098821 BMP receptor activity(GO:0098821)
0.0 1.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.8 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.8 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 2.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 1.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 2.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.0 GO:0070698 type I activin receptor binding(GO:0070698)
0.0 0.2 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.1 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.0 2.3 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.2 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 1.7 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.2 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.2 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.2 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 2.5 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 1.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 8.0 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0 0.1 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.6 GO:0051087 chaperone binding(GO:0051087)
0.0 2.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 11.4 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.5 13.7 ST G ALPHA S PATHWAY G alpha s Pathway
0.4 29.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.4 39.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.3 16.8 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.3 13.9 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.2 2.0 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2 0.6 PID IL27 PATHWAY IL27-mediated signaling events
0.1 9.3 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 5.1 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 6.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 3.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 3.0 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 4.0 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 1.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.8 PID IL1 PATHWAY IL1-mediated signaling events
0.1 3.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 1.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 1.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 5.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 6.1 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 2.3 PID IL23 PATHWAY IL23-mediated signaling events
0.1 4.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 0.5 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 1.4 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 2.0 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 10.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.8 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 0.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 1.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 4.7 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.3 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.8 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.4 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.7 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.3 PID SHP2 PATHWAY SHP2 signaling
0.0 1.7 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.7 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.4 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 3.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.2 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.7 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.2 PID ALK2 PATHWAY ALK2 signaling events
0.0 3.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.7 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.9 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.4 PID P73PATHWAY p73 transcription factor network
0.0 0.5 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.3 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.4 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
1.1 21.7 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
1.0 13.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.9 16.8 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.8 15.5 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.8 14.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.7 15.3 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.6 27.0 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.5 2.2 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.5 15.7 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.5 5.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.5 6.0 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.4 20.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.4 9.7 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.4 7.1 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.3 15.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.3 3.3 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.3 2.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.3 1.0 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.2 3.1 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.2 6.2 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.2 10.2 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.2 1.9 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.2 1.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 7.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 15.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 1.9 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.1 1.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 2.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 2.9 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 0.7 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.1 9.7 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 2.0 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.0 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 4.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 2.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 2.9 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 0.9 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 8.5 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.1 0.9 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 1.5 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 2.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.7 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 1.1 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.5 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 2.4 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 1.5 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 0.5 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.1 4.3 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.7 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 1.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 0.5 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 0.8 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.6 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 0.3 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 1.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.4 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 5.0 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.1 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.6 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 2.2 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0 2.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.3 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.9 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.9 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.4 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.6 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.6 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 1.0 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.5 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.7 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.4 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.9 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.0 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.5 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.6 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.5 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.1 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.1 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 0.3 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 2.4 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.1 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.2 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4