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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Irf2_Irf1_Irf8_Irf9_Irf7
Z-value: 1.87
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Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000031627.7 | interferon regulatory factor 2 | |
| ENSMUSG00000018899.10 | interferon regulatory factor 1 | |
| ENSMUSG00000041515.3 | interferon regulatory factor 8 | |
| ENSMUSG00000002325.8 | interferon regulatory factor 9 | |
| ENSMUSG00000025498.8 | interferon regulatory factor 7 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Irf1 | mm10_v2_chr11_+_53770458_53770509 | 0.51 | 1.5e-03 | Click! |
| Irf7 | mm10_v2_chr7_-_141266415_141266481 | 0.49 | 2.3e-03 | Click! |
| Irf2 | mm10_v2_chr8_+_46739745_46739791 | 0.37 | 2.6e-02 | Click! |
| Irf8 | mm10_v2_chr8_+_120736352_120736385 | -0.34 | 4.4e-02 | Click! |
| Irf9 | mm10_v2_chr14_+_55604550_55604579 | 0.22 | 1.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_77729091 Show fit | 33.28 |
ENSMUST00000109775.2
|
apolipoprotein L 9b |
|
| chr1_+_130826676 Show fit | 19.85 |
ENSMUST00000027675.7
|
polymeric immunoglobulin receptor |
|
| chr1_+_130826762 Show fit | 18.74 |
ENSMUST00000133792.1
|
polymeric immunoglobulin receptor |
|
| chr15_-_77411034 Show fit | 17.58 |
ENSMUST00000089452.5
ENSMUST00000081776.3 |
apolipoprotein L 9a |
|
| chr2_-_173218879 Show fit | 16.47 |
ENSMUST00000109116.2
ENSMUST00000029018.7 |
Z-DNA binding protein 1 |
|
| chr4_+_42629719 Show fit | 14.27 |
ENSMUST00000166898.2
|
predicted gene 2564 |
|
| chr8_-_71537402 Show fit | 13.78 |
ENSMUST00000051672.7
|
bone marrow stromal cell antigen 2 |
|
| chr19_+_34607927 Show fit | 13.35 |
ENSMUST00000076249.5
|
RIKEN cDNA I830012O16 gene |
|
| chr8_-_45333189 Show fit | 12.55 |
ENSMUST00000095328.4
|
cytochrome P450, family 4, subfamily v, polypeptide 3 |
|
| chr19_+_34640871 Show fit | 12.19 |
ENSMUST00000102824.3
|
interferon-induced protein with tetratricopeptide repeats 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 176.4 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 0.9 | 70.7 | GO:0034341 | response to interferon-gamma(GO:0034341) |
| 3.5 | 41.6 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 9.6 | 38.6 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 7.3 | 22.0 | GO:1990166 | protein localization to site of double-strand break(GO:1990166) |
| 0.1 | 19.0 | GO:0007286 | spermatid development(GO:0007286) |
| 0.4 | 17.7 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 2.9 | 17.2 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 1.9 | 17.1 | GO:0060340 | positive regulation of type I interferon-mediated signaling pathway(GO:0060340) |
| 0.1 | 15.3 | GO:0019395 | fatty acid oxidation(GO:0019395) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 66.1 | GO:0005829 | cytosol(GO:0005829) |
| 4.2 | 58.2 | GO:0020003 | symbiont-containing vacuole(GO:0020003) |
| 0.1 | 50.3 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.9 | 38.6 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 2.7 | 32.3 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 27.3 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 26.7 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 23.0 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 20.4 | GO:0045177 | apical part of cell(GO:0045177) |
| 0.1 | 17.1 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 92.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 3.9 | 39.0 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 1.0 | 38.3 | GO:0008009 | chemokine activity(GO:0008009) |
| 2.0 | 24.0 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 2.4 | 22.0 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 0.1 | 18.7 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.8 | 18.4 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 2.4 | 17.0 | GO:0046978 | TAP1 binding(GO:0046978) TAP2 binding(GO:0046979) |
| 2.4 | 16.7 | GO:0004556 | alpha-amylase activity(GO:0004556) |
| 0.2 | 16.5 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 39.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.4 | 29.9 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.3 | 16.8 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.3 | 13.9 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.5 | 13.7 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 1.1 | 11.4 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 10.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 9.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 6.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 6.1 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 27.0 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 1.1 | 21.7 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.4 | 20.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.9 | 16.8 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.5 | 15.7 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.8 | 15.5 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.3 | 15.5 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.2 | 15.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.7 | 15.3 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.8 | 14.7 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |