Project
avrg: GSE58827: Dynamics of the Mouse Liver
Navigation
Downloads
Results for Hsf4
Z-value: 1.45
Motif logo
Transcription factors associated with Hsf4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hsf4 | mm10_v2_chr8_+_105269837_105269874 | 0.56 | 3.5e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hsf4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 15.3 | GO:0015747 | urate transport(GO:0015747) |
| 1.5 | 8.9 | GO:0045583 | regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585) |
| 0.2 | 8.8 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.7 | 5.9 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) |
| 1.7 | 5.2 | GO:0070342 | brown fat cell proliferation(GO:0070342) regulation of brown fat cell proliferation(GO:0070347) |
| 0.5 | 3.8 | GO:1903751 | regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751) |
| 0.9 | 3.7 | GO:0030026 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071) |
| 0.4 | 3.6 | GO:0099640 | positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033) axo-dendritic protein transport(GO:0099640) |
| 0.1 | 3.6 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
| 0.1 | 3.5 | GO:0046470 | phosphatidylcholine metabolic process(GO:0046470) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 10.6 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 1.8 | 8.9 | GO:0097226 | sperm mitochondrial sheath(GO:0097226) |
| 0.2 | 5.2 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.0 | 5.2 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.0 | 5.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 3.5 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 3.5 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 2.3 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 2.2 | GO:0005811 | lipid particle(GO:0005811) |
| 0.3 | 2.1 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 15.3 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.8 | 10.6 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 1.3 | 7.7 | GO:0002135 | CTP binding(GO:0002135) |
| 2.0 | 5.9 | GO:0004155 | 6,7-dihydropteridine reductase activity(GO:0004155) |
| 0.2 | 5.4 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.1 | 5.4 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.2 | 5.2 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.0 | 4.2 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.0 | 3.8 | GO:0015293 | symporter activity(GO:0015293) |
| 0.9 | 3.7 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 8.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 4.4 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 3.7 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 3.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 3.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 3.0 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 2.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.7 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 1.5 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.4 | 8.9 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.1 | 5.1 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 3.7 | REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT | Genes involved in Lipid digestion, mobilization, and transport |
| 0.3 | 3.6 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.1 | 3.4 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.1 | 2.9 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 2.8 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 2.3 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 2.2 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |