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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Hoxd11_Cdx1_Hoxc11
Z-value: 2.27
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Transcription factors associated with Hoxd11_Cdx1_Hoxc11
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hoxc11 | mm10_v2_chr15_+_102954427_102954427 | 0.56 | 4.1e-04 | Click! |
| Hoxd11 | mm10_v2_chr2_+_74681991_74682007 | 0.51 | 1.6e-03 | Click! |
| Cdx1 | mm10_v2_chr18_-_61036189_61036210 | 0.35 | 3.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_142661858 Show fit | 26.03 |
ENSMUST00000145896.2
|
insulin-like growth factor 2 |
|
| chr2_+_84988194 Show fit | 14.26 |
ENSMUST00000028466.5
|
proteoglycan 3 |
|
| chr14_-_37110087 Show fit | 9.22 |
ENSMUST00000179488.1
|
RIKEN cDNA 2610528A11 gene |
|
| chrX_+_96455359 Show fit | 8.47 |
ENSMUST00000033553.7
|
hephaestin |
|
| chr1_+_107535508 Show fit | 7.94 |
ENSMUST00000182198.1
|
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10 |
|
| chr19_-_45812291 Show fit | 6.77 |
ENSMUST00000086993.4
|
Kv channel-interacting protein 2 |
|
| chr17_+_5799491 Show fit | 6.44 |
ENSMUST00000181484.1
|
RIKEN cDNA 3300005D01 gene |
|
| chr1_-_45503282 Show fit | 6.34 |
ENSMUST00000086430.4
|
collagen, type V, alpha 2 |
|
| chr2_+_155611175 Show fit | 5.90 |
ENSMUST00000092995.5
|
myosin, heavy chain 7B, cardiac muscle, beta |
|
| chr9_+_62858085 Show fit | 5.64 |
ENSMUST00000034777.6
ENSMUST00000163820.1 |
calmodulin-like 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hoxd11_Cdx1_Hoxc11
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 26.0 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 3.6 | 14.3 | GO:0045575 | basophil activation(GO:0045575) |
| 0.7 | 10.6 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.3 | 9.0 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.8 | 8.3 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.1 | 8.2 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 1.4 | 6.8 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
| 1.6 | 6.3 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.1 | 6.1 | GO:0070303 | negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303) |
| 0.1 | 5.8 | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.6 | 15.7 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 12.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 6.8 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 2.1 | 6.3 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.7 | 5.9 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.0 | 5.1 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.3 | 4.9 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.1 | 4.4 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 4.2 | GO:0005903 | brush border(GO:0005903) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 26.6 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.1 | 16.1 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 13.1 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.6 | 10.6 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.1 | 9.9 | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.8 | 8.5 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.1 | 8.2 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 7.6 | GO:0003774 | motor activity(GO:0003774) |
| 1.4 | 6.8 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.1 | 6.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 28.1 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.3 | 12.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 10.3 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 8.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 7.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 5.3 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.1 | 5.1 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 4.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 3.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 26.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 8.5 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 7.7 | REACTOME SIGNALING BY EGFR IN CANCER | Genes involved in Signaling by EGFR in Cancer |
| 0.4 | 5.3 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 5.1 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 4.6 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.4 | 4.1 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.1 | 3.1 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 2.9 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 2.5 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |