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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Hoxb8_Pdx1
Z-value: 1.97
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Transcription factors associated with Hoxb8_Pdx1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hoxb8 | mm10_v2_chr11_+_96282529_96282556 | -0.41 | 1.3e-02 | Click! |
| Pdx1 | mm10_v2_chr5_+_147269959_147270102 | -0.24 | 1.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_130826762 Show fit | 17.70 |
ENSMUST00000133792.1
|
polymeric immunoglobulin receptor |
|
| chr11_-_58613481 Show fit | 10.98 |
ENSMUST00000048801.7
|
RIKEN cDNA 2210407C18 gene |
|
| chr13_-_23914998 Show fit | 9.97 |
ENSMUST00000021769.8
ENSMUST00000110407.2 |
solute carrier family 17 (sodium phosphate), member 4 |
|
| chr19_+_4711153 Show fit | 9.80 |
ENSMUST00000008991.6
|
spectrin beta, non-erythrocytic 2 |
|
| chr8_-_110039330 Show fit | 7.60 |
ENSMUST00000109222.2
|
carbohydrate (chondroitin 6/keratan) sulfotransferase 4 |
|
| chr6_-_89216237 Show fit | 7.44 |
ENSMUST00000079186.2
|
predicted gene 839 |
|
| chr6_+_124304646 Show fit | 6.95 |
ENSMUST00000112541.2
ENSMUST00000032234.2 |
CD163 antigen |
|
| chr8_-_5105232 Show fit | 6.83 |
ENSMUST00000023835.1
|
solute carrier family 10, member 2 |
|
| chr7_-_46742979 Show fit | 6.79 |
ENSMUST00000128088.1
|
serum amyloid A 1 |
|
| chr7_+_46751832 Show fit | 5.79 |
ENSMUST00000075982.2
|
serum amyloid A 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hoxb8_Pdx1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 20.1 | GO:0006953 | acute-phase response(GO:0006953) |
| 4.4 | 17.7 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 0.1 | 12.8 | GO:0035725 | sodium ion transmembrane transport(GO:0035725) |
| 0.4 | 10.0 | GO:0021692 | cerebellar Purkinje cell layer morphogenesis(GO:0021692) |
| 0.8 | 8.8 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 2.5 | 7.6 | GO:0042339 | keratan sulfate metabolic process(GO:0042339) |
| 0.4 | 7.4 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.3 | 6.8 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 1.9 | 5.7 | GO:0001868 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 0.3 | 5.6 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.3 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.4 | 17.9 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.4 | 13.6 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 13.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.3 | 11.1 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 1.4 | 9.8 | GO:0008091 | spectrin(GO:0008091) |
| 1.1 | 8.0 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.1 | 6.8 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.0 | 6.8 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.2 | 4.9 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 20.5 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 1.8 | 17.7 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 0.3 | 13.1 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.9 | 12.3 | GO:0005436 | sodium:phosphate symporter activity(GO:0005436) |
| 0.3 | 9.0 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 8.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 1.3 | 7.6 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 0.1 | 7.1 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 1.0 | 6.8 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 2.0 | 6.0 | GO:0016838 | carbon-oxygen lyase activity, acting on phosphates(GO:0016838) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 9.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 7.1 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.2 | 6.8 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 6.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 4.0 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 3.0 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 3.0 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 2.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 7.4 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.8 | 6.8 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.3 | 6.8 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.7 | 5.7 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 5.7 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 5.0 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 4.9 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.2 | 4.1 | REACTOME ACTIVATED POINT MUTANTS OF FGFR2 | Genes involved in Activated point mutants of FGFR2 |
| 0.1 | 4.0 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |