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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Hoxa4
Z-value: 1.92
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Transcription factors associated with Hoxa4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hoxa4 | mm10_v2_chr6_-_52191695_52191753 | -0.52 | 1.3e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hoxa4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 13.4 | GO:1904075 | regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
| 0.8 | 13.4 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 2.6 | 7.7 | GO:1903002 | regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002) |
| 0.7 | 6.5 | GO:0008300 | isoprenoid catabolic process(GO:0008300) |
| 0.6 | 6.0 | GO:0051596 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 0.0 | 6.0 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 1.1 | 5.5 | GO:0021914 | negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914) |
| 0.9 | 5.3 | GO:0038161 | prolactin signaling pathway(GO:0038161) |
| 1.4 | 4.1 | GO:0001982 | baroreceptor response to decreased systemic arterial blood pressure(GO:0001982) |
| 0.1 | 3.9 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 13.4 | GO:0042567 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) insulin-like growth factor ternary complex(GO:0042567) |
| 1.5 | 7.7 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.1 | 4.4 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 4.2 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 3.8 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 3.8 | GO:0042641 | actomyosin(GO:0042641) |
| 0.0 | 3.8 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 3.6 | GO:0030315 | T-tubule(GO:0030315) |
| 0.4 | 3.2 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.0 | 2.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 13.4 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.4 | 9.6 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.3 | 9.3 | GO:0005550 | pheromone binding(GO:0005550) |
| 2.6 | 7.7 | GO:0046911 | metal chelating activity(GO:0046911) |
| 0.0 | 7.7 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.7 | 6.0 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 0.2 | 5.8 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 1.1 | 5.3 | GO:0004925 | prolactin receptor activity(GO:0004925) |
| 0.1 | 4.4 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 1.0 | 4.1 | GO:0004937 | alpha1-adrenergic receptor activity(GO:0004937) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.3 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.2 | 12.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 8.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 6.3 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 5.3 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 4.8 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.1 | 4.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 4.4 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 4.3 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 3.9 | PID P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.7 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.4 | 7.7 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.3 | 5.3 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 4.5 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.1 | 3.9 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.3 | 3.2 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.0 | 3.1 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 2.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 2.7 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.1 | 2.4 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |