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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Glis2
Z-value: 1.09
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Transcription factors associated with Glis2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Glis2 | mm10_v2_chr16_+_4594683_4594735 | 0.57 | 2.7e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_20269162 Show fit | 7.38 |
ENSMUST00000024155.7
|
potassium channel, subfamily K, member 16 |
|
| chr7_-_103843154 Show fit | 6.30 |
ENSMUST00000063957.4
|
hemoglobin Z, beta-like embryonic chain |
|
| chr11_+_87793722 Show fit | 5.57 |
ENSMUST00000143021.2
|
myeloperoxidase |
|
| chr12_+_109544498 Show fit | 5.16 |
ENSMUST00000126289.1
|
maternally expressed 3 |
|
| chr2_-_170427828 Show fit | 5.06 |
ENSMUST00000013667.2
ENSMUST00000109152.2 ENSMUST00000068137.4 |
breast carcinoma amplified sequence 1 |
|
| chr19_+_7268296 Show fit | 4.67 |
ENSMUST00000066646.4
|
REST corepressor 2 |
|
| chr11_+_87793470 Show fit | 4.62 |
ENSMUST00000020779.4
|
myeloperoxidase |
|
| chr4_-_118620763 Show fit | 3.87 |
ENSMUST00000071972.4
|
WD repeat domain 65 |
|
| chr4_+_115059507 Show fit | 3.85 |
ENSMUST00000162489.1
|
T cell acute lymphocytic leukemia 1 |
|
| chr8_+_72761868 Show fit | 3.75 |
ENSMUST00000058099.8
|
coagulation factor II (thrombin) receptor-like 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Glis2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 10.2 | GO:0002148 | hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149) |
| 0.3 | 7.6 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 0.4 | 6.6 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.8 | 6.3 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.8 | 4.8 | GO:0032796 | uropod organization(GO:0032796) |
| 1.3 | 3.9 | GO:0060217 | hemangioblast cell differentiation(GO:0060217) |
| 0.2 | 3.7 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.2 | 3.7 | GO:0001675 | acrosome assembly(GO:0001675) |
| 1.2 | 3.6 | GO:0010751 | negative regulation of nitric oxide mediated signal transduction(GO:0010751) regulation of cGMP-mediated signaling(GO:0010752) |
| 1.2 | 3.5 | GO:0034224 | cellular response to zinc ion starvation(GO:0034224) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 10.7 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.8 | 6.3 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.2 | 5.0 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.0 | 4.6 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 1.3 | 3.9 | GO:0033193 | Lsd1/2 complex(GO:0033193) |
| 0.4 | 3.6 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 3.5 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.3 | 3.2 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 2.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.2 | 2.6 | GO:0097208 | alveolar lamellar body(GO:0097208) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.2 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.4 | 6.6 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 1.6 | 6.3 | GO:0031721 | hemoglobin alpha binding(GO:0031721) |
| 0.2 | 4.8 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.1 | 4.7 | GO:0070888 | E-box binding(GO:0070888) |
| 0.9 | 3.7 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 0.9 | 3.6 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.1 | 3.5 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.3 | 3.2 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.0 | 3.2 | GO:0003714 | transcription corepressor activity(GO:0003714) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.2 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.2 | 3.7 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 3.6 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 3.2 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 3.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 2.4 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 2.4 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 2.3 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 2.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.1 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.6 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.1 | 5.6 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.1 | 3.5 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 3.5 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 3.3 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 3.2 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.1 | 2.5 | REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.0 | 2.4 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.1 | 2.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 2.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |