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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Gli2
Z-value: 1.48
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Transcription factors associated with Gli2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Gli2 | mm10_v2_chr1_-_119053619_119053638 | -0.82 | 6.3e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Gli2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.8 | GO:0006892 | post-Golgi vesicle-mediated transport(GO:0006892) |
| 0.0 | 6.4 | GO:0007059 | chromosome segregation(GO:0007059) |
| 1.0 | 6.1 | GO:0003383 | apical constriction(GO:0003383) |
| 0.1 | 4.1 | GO:0046457 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
| 0.4 | 4.0 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.1 | 3.8 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
| 0.0 | 3.8 | GO:0072583 | clathrin-mediated endocytosis(GO:0072583) |
| 1.2 | 3.6 | GO:1900106 | hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
| 0.2 | 3.5 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 0.1 | 3.4 | GO:0007520 | myoblast fusion(GO:0007520) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.8 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.8 | 6.1 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.3 | 3.8 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.3 | 3.4 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 3.1 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.5 | 2.7 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.0 | 2.6 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 2.4 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 2.4 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 2.0 | GO:0005811 | lipid particle(GO:0005811) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.2 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.1 | 6.1 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 4.9 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 4.1 | GO:0016209 | antioxidant activity(GO:0016209) |
| 0.4 | 4.0 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.3 | 3.8 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.4 | 3.6 | GO:0004415 | hyalurononglucosaminidase activity(GO:0004415) |
| 0.3 | 3.6 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.4 | 3.5 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 1.0 | 2.9 | GO:0017082 | mineralocorticoid receptor activity(GO:0017082) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.3 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 3.9 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 3.8 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 3.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 2.7 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 2.6 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 2.4 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.0 | 1.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 1.4 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 1.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.4 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 6.1 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.2 | 3.8 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.3 | 3.6 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 3.4 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 2.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 2.7 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 2.6 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.2 | 2.4 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 1.7 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |