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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Gli2

Z-value: 1.48

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Transcription factors associated with Gli2

Gene Symbol Gene ID Gene Info
Gli2
ENSMUSG00000048402.8 GLI-Kruppel family member GLI2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gli2mm10_v2_chr1_-_119053619_119053638-0.826.3e-10Click!

Activity profile of Gli2 motif

Sorted Z-values of Gli2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_53213447 4.94 ENSMUST00000031090.6
Sel1l3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr1_-_51915901 4.65 ENSMUST00000018561.7
ENSMUST00000114537.2
Myo1b
myosin IB
chr1_-_51915968 4.11 ENSMUST00000046390.7
Myo1b
myosin IB
chr4_-_154899077 4.10 ENSMUST00000030935.3
ENSMUST00000132281.1
Fam213b
family with sequence similarity 213, member B
chr3_+_97628804 4.02 ENSMUST00000107050.1
ENSMUST00000029729.8
ENSMUST00000107049.1
Fmo5
flavin containing monooxygenase 5
chr1_-_180199587 3.82 ENSMUST00000161743.1
Adck3
aarF domain containing kinase 3
chr9_+_107576915 3.56 ENSMUST00000112387.2
ENSMUST00000123005.1
ENSMUST00000010195.7
ENSMUST00000144392.1
Hyal1
hyaluronoglucosaminidase 1
chr17_-_24209377 3.43 ENSMUST00000024931.4
Ntn3
netrin 3
chr7_-_81454751 3.41 ENSMUST00000098331.3
ENSMUST00000178892.1
Cpeb1
cytoplasmic polyadenylation element binding protein 1
chr8_+_76902277 2.89 ENSMUST00000109912.1
ENSMUST00000128862.1
ENSMUST00000109911.1
Nr3c2
nuclear receptor subfamily 3, group C, member 2
chr10_-_114801364 2.58 ENSMUST00000061632.7
Trhde
TRH-degrading enzyme
chr4_-_121098190 2.56 ENSMUST00000058754.2
Zmpste24
zinc metallopeptidase, STE24
chr12_-_70227622 2.56 ENSMUST00000071250.6
Pygl
liver glycogen phosphorylase
chr9_+_100643755 2.53 ENSMUST00000133388.1
Stag1
stromal antigen 1
chrX_+_161717498 2.52 ENSMUST00000061514.7
Rai2
retinoic acid induced 2
chr2_+_69897255 2.40 ENSMUST00000131553.1
Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr5_-_139819906 2.34 ENSMUST00000147328.1
Tmem184a
transmembrane protein 184a
chr9_+_100643605 2.19 ENSMUST00000041418.6
Stag1
stromal antigen 1
chr8_+_127064107 2.14 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr13_-_54611274 2.08 ENSMUST00000049575.7
Cltb
clathrin, light polypeptide (Lcb)
chr8_+_127064022 2.01 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr19_-_43674844 1.94 ENSMUST00000046038.7
Slc25a28
solute carrier family 25, member 28
chr8_+_127063893 1.94 ENSMUST00000162309.1
Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr4_-_46536096 1.92 ENSMUST00000102924.2
Trim14
tripartite motif-containing 14
chr9_-_43239816 1.92 ENSMUST00000034512.5
Oaf
OAF homolog (Drosophila)
chr4_-_46536134 1.87 ENSMUST00000046897.6
Trim14
tripartite motif-containing 14
chrX_-_9662950 1.86 ENSMUST00000033519.2
Dynlt3
dynein light chain Tctex-type 3
chr6_+_113471481 1.83 ENSMUST00000113062.1
Il17rc
interleukin 17 receptor C
chr10_+_80151154 1.82 ENSMUST00000146516.1
ENSMUST00000144526.1
Midn
midnolin
chr16_-_17132377 1.79 ENSMUST00000023453.7
Sdf2l1
stromal cell-derived factor 2-like 1
chr13_-_54611332 1.76 ENSMUST00000091609.4
Cltb
clathrin, light polypeptide (Lcb)
chr11_-_121388186 1.70 ENSMUST00000106107.2
Rab40b
Rab40b, member RAS oncogene family
chr1_-_90967667 1.70 ENSMUST00000131428.1
Rab17
RAB17, member RAS oncogene family
chr2_-_157566319 1.70 ENSMUST00000109528.2
ENSMUST00000088494.2
Blcap
bladder cancer associated protein homolog (human)
chr6_+_113471427 1.69 ENSMUST00000058300.7
Il17rc
interleukin 17 receptor C
chr9_+_100643448 1.64 ENSMUST00000146312.1
ENSMUST00000129269.1
Stag1
stromal antigen 1
chr2_-_121380940 1.64 ENSMUST00000038389.8
Strc
stereocilin
chr5_-_135962275 1.61 ENSMUST00000054895.3
Srcrb4d
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr9_+_109095427 1.54 ENSMUST00000072093.6
Plxnb1
plexin B1
chr7_+_35119285 1.53 ENSMUST00000042985.9
Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr7_-_144738520 1.44 ENSMUST00000118556.2
ENSMUST00000033393.8
Ano1
anoctamin 1, calcium activated chloride channel
chr19_+_6047081 1.41 ENSMUST00000025723.8
Syvn1
synovial apoptosis inhibitor 1, synoviolin
chr2_+_140395309 1.38 ENSMUST00000110067.1
ENSMUST00000110064.1
ENSMUST00000110063.1
ENSMUST00000110062.1
ENSMUST00000078027.5
ENSMUST00000043836.7
Macrod2
MACRO domain containing 2
chr7_-_144738478 1.35 ENSMUST00000121758.1
Ano1
anoctamin 1, calcium activated chloride channel
chr17_+_28691342 1.30 ENSMUST00000114758.1
ENSMUST00000004990.6
ENSMUST00000062694.8
ENSMUST00000114754.1
Mapk14
mitogen-activated protein kinase 14
chr2_-_37703275 1.29 ENSMUST00000072186.5
Strbp
spermatid perinuclear RNA binding protein
chr19_+_6047055 1.29 ENSMUST00000134667.1
Syvn1
synovial apoptosis inhibitor 1, synoviolin
chr7_+_81571246 1.28 ENSMUST00000165460.1
Whamm
WAS protein homolog associated with actin, golgi membranes and microtubules
chr6_+_43265582 1.28 ENSMUST00000031750.7
Arhgef5
Rho guanine nucleotide exchange factor (GEF) 5
chr12_-_31950170 1.27 ENSMUST00000176520.1
Hbp1
high mobility group box transcription factor 1
chrX_-_74023908 1.26 ENSMUST00000033769.8
ENSMUST00000114352.1
ENSMUST00000068286.5
ENSMUST00000114360.3
ENSMUST00000114354.3
Irak1
interleukin-1 receptor-associated kinase 1
chr10_+_83543941 1.24 ENSMUST00000038388.5
A230046K03Rik
RIKEN cDNA A230046K03 gene
chr1_-_175625580 1.24 ENSMUST00000027810.7
Fh1
fumarate hydratase 1
chr11_+_29526423 1.18 ENSMUST00000136351.1
ENSMUST00000020749.6
ENSMUST00000144321.1
ENSMUST00000093239.4
Mtif2
mitochondrial translational initiation factor 2
chrX_-_141725181 1.17 ENSMUST00000067841.7
Irs4
insulin receptor substrate 4
chr11_+_29526407 1.17 ENSMUST00000133452.1
Mtif2
mitochondrial translational initiation factor 2
chr7_-_121035096 1.14 ENSMUST00000065740.2
Gm9905
predicted gene 9905
chr8_-_13890233 1.13 ENSMUST00000033839.7
Coprs
coordinator of PRMT5, differentiation stimulator
chr15_+_41447438 1.13 ENSMUST00000110297.2
ENSMUST00000090096.4
Oxr1
oxidation resistance 1
chr7_+_121707189 1.12 ENSMUST00000065310.2
1700069B07Rik
RIKEN cDNA 1700069B07 gene
chr7_+_102578469 1.09 ENSMUST00000098225.2
Olfr550
olfactory receptor 550
chr17_+_28691419 1.09 ENSMUST00000124886.1
Mapk14
mitogen-activated protein kinase 14
chr4_-_140648736 1.09 ENSMUST00000039204.3
ENSMUST00000105799.1
ENSMUST00000097820.2
Arhgef10l
Rho guanine nucleotide exchange factor (GEF) 10-like
chr5_-_135962265 1.09 ENSMUST00000111150.1
Srcrb4d
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr2_+_49451486 1.08 ENSMUST00000092123.4
Epc2
enhancer of polycomb homolog 2 (Drosophila)
chr7_-_133123312 1.07 ENSMUST00000171022.1
ENSMUST00000163601.1
ENSMUST00000165534.1
ENSMUST00000033269.8
ENSMUST00000124096.1
Ctbp2
Fgfr2
C-terminal binding protein 2
fibroblast growth factor receptor 2
chr9_+_62342449 1.07 ENSMUST00000156461.1
Anp32a
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr4_+_43401232 1.06 ENSMUST00000125399.1
Rusc2
RUN and SH3 domain containing 2
chr4_-_19708922 1.06 ENSMUST00000108246.2
Wwp1
WW domain containing E3 ubiquitin protein ligase 1
chrX_+_161717055 1.05 ENSMUST00000112338.1
Rai2
retinoic acid induced 2
chr2_+_130576170 1.02 ENSMUST00000028764.5
Oxt
oxytocin
chr1_+_167349976 1.01 ENSMUST00000028004.9
Aldh9a1
aldehyde dehydrogenase 9, subfamily A1
chr12_-_31950210 0.99 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
Hbp1
high mobility group box transcription factor 1
chr2_+_160731684 0.99 ENSMUST00000174885.1
ENSMUST00000109462.1
Plcg1
phospholipase C, gamma 1
chr6_-_124464772 0.98 ENSMUST00000008297.4
Clstn3
calsyntenin 3
chr11_+_70844745 0.97 ENSMUST00000076270.6
ENSMUST00000179114.1
ENSMUST00000100928.4
ENSMUST00000177731.1
ENSMUST00000108533.3
ENSMUST00000081362.6
ENSMUST00000178245.1
Rabep1
rabaptin, RAB GTPase binding effector protein 1
chr18_-_35215008 0.96 ENSMUST00000091636.3
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr17_+_24669730 0.95 ENSMUST00000047179.5
Zfp598
zinc finger protein 598
chr16_-_31314804 0.93 ENSMUST00000115230.1
ENSMUST00000130560.1
Apod
apolipoprotein D
chr11_+_72796254 0.90 ENSMUST00000069395.5
Zzef1
zinc finger, ZZ-type with EF hand domain 1
chr10_-_34127955 0.90 ENSMUST00000062784.6
Fam26f
family with sequence similarity 26, member F
chr8_-_67515606 0.90 ENSMUST00000032981.5
Gm9755
predicted pseudogene 9755
chr5_-_71095765 0.88 ENSMUST00000000572.5
Gabra2
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2
chr11_+_72796164 0.87 ENSMUST00000172220.1
Zzef1
zinc finger, ZZ-type with EF hand domain 1
chr11_+_73329727 0.85 ENSMUST00000092926.4
ENSMUST00000117445.1
Spata22
spermatogenesis associated 22
chr7_-_116308241 0.85 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
Plekha7
pleckstrin homology domain containing, family A member 7
chr8_+_85060055 0.84 ENSMUST00000095220.3
Fbxw9
F-box and WD-40 domain protein 9
chr5_-_134456227 0.82 ENSMUST00000111244.1
Gtf2ird1
general transcription factor II I repeat domain-containing 1
chr2_+_164486455 0.82 ENSMUST00000069385.8
ENSMUST00000143690.1
Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr7_-_137314394 0.81 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
Ebf3
early B cell factor 3
chr9_+_45055211 0.81 ENSMUST00000114663.2
Mpzl3
myelin protein zero-like 3
chr9_+_55149364 0.80 ENSMUST00000121677.1
Ube2q2
ubiquitin-conjugating enzyme E2Q (putative) 2
chrX_-_95956890 0.80 ENSMUST00000079987.6
ENSMUST00000113864.2
Las1l
LAS1-like (S. cerevisiae)
chr11_+_95712673 0.75 ENSMUST00000107717.1
Zfp652
zinc finger protein 652
chr18_+_61555689 0.75 ENSMUST00000167187.1
Csnk1a1
casein kinase 1, alpha 1
chr17_-_34214459 0.75 ENSMUST00000121995.1
Gm15821
predicted gene 15821
chr18_+_38250240 0.75 ENSMUST00000025314.5
0610009O20Rik
RIKEN cDNA 0610009O20 gene
chr4_-_126256226 0.74 ENSMUST00000122129.1
ENSMUST00000061143.8
ENSMUST00000106132.2
Map7d1
MAP7 domain containing 1
chr3_+_94837533 0.73 ENSMUST00000107270.2
Pogz
pogo transposable element with ZNF domain
chr2_-_120609500 0.72 ENSMUST00000133612.1
ENSMUST00000102498.1
ENSMUST00000102499.1
Lrrc57
leucine rich repeat containing 57
chr10_+_76531593 0.71 ENSMUST00000048678.6
Lss
lanosterol synthase
chr17_+_24632671 0.71 ENSMUST00000047611.2
Nthl1
nth (endonuclease III)-like 1 (E.coli)
chr3_+_127633134 0.71 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr5_-_24527276 0.71 ENSMUST00000088311.4
Gbx1
gastrulation brain homeobox 1
chr2_-_120609319 0.66 ENSMUST00000102497.3
Lrrc57
leucine rich repeat containing 57
chr8_-_27174623 0.64 ENSMUST00000033878.6
ENSMUST00000054212.6
Rab11fip1
RAB11 family interacting protein 1 (class I)
chr15_-_78718113 0.61 ENSMUST00000088592.4
Elfn2
leucine rich repeat and fibronectin type III, extracellular 2
chr14_+_25607797 0.61 ENSMUST00000160229.1
Zmiz1
zinc finger, MIZ-type containing 1
chr8_+_70754679 0.60 ENSMUST00000110093.2
ENSMUST00000143118.1
ENSMUST00000034301.5
ENSMUST00000110090.1
Rab3a
RAB3A, member RAS oncogene family
chr17_-_25497288 0.59 ENSMUST00000165183.2
ENSMUST00000051864.4
Sstr5
somatostatin receptor 5
chr16_-_4077778 0.59 ENSMUST00000006137.8
Trap1
TNF receptor-associated protein 1
chr14_-_64949838 0.58 ENSMUST00000067843.3
ENSMUST00000176489.1
ENSMUST00000175905.1
ENSMUST00000022544.7
ENSMUST00000175744.1
ENSMUST00000176128.1
Hmbox1
homeobox containing 1
chr11_-_94704499 0.58 ENSMUST00000069852.1
Gm11541
predicted gene 11541
chr10_-_17947997 0.57 ENSMUST00000037879.6
Heca
headcase homolog (Drosophila)
chr19_-_8880883 0.57 ENSMUST00000096253.5
AI462493
expressed sequence AI462493
chr11_+_116030304 0.55 ENSMUST00000021116.5
ENSMUST00000106452.1
Unk
unkempt homolog (Drosophila)
chr10_-_127263346 0.55 ENSMUST00000099172.3
Kif5a
kinesin family member 5A
chr9_+_45055166 0.54 ENSMUST00000114664.1
ENSMUST00000093856.3
Mpzl3
myelin protein zero-like 3
chr4_-_135971894 0.53 ENSMUST00000105852.1
Lypla2
lysophospholipase 2
chr2_+_121956411 0.53 ENSMUST00000110578.1
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr17_-_56609689 0.53 ENSMUST00000052832.5
2410015M20Rik
RIKEN cDNA 2410015M20 gene
chr2_-_120609283 0.52 ENSMUST00000102496.1
Lrrc57
leucine rich repeat containing 57
chr8_+_107436355 0.52 ENSMUST00000166615.1
Wwp2
WW domain containing E3 ubiquitin protein ligase 2
chrX_-_167382747 0.51 ENSMUST00000026839.4
Prps2
phosphoribosyl pyrophosphate synthetase 2
chr9_+_107928440 0.51 ENSMUST00000085073.1
Actl11
actin-like 11
chr11_-_68871848 0.50 ENSMUST00000101017.2
Ndel1
nuclear distribution gene E-like homolog 1 (A. nidulans)
chr11_-_107794557 0.50 ENSMUST00000021066.3
Cacng4
calcium channel, voltage-dependent, gamma subunit 4
chr11_+_117308135 0.50 ENSMUST00000153668.1
Sept9
septin 9
chr7_-_65371210 0.49 ENSMUST00000102592.3
Tjp1
tight junction protein 1
chr11_+_115912001 0.49 ENSMUST00000132961.1
Smim6
small integral membrane protein 6
chr2_+_120609383 0.47 ENSMUST00000124187.1
Haus2
HAUS augmin-like complex, subunit 2
chr11_-_42000532 0.47 ENSMUST00000070735.3
Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr12_+_72085847 0.41 ENSMUST00000117449.1
ENSMUST00000057257.8
Jkamp
JNK1/MAPK8-associated membrane protein
chr3_+_95427575 0.41 ENSMUST00000181809.1
Gm4349
predicted gene 4349
chr4_+_155831630 0.41 ENSMUST00000105592.1
ENSMUST00000105591.1
Aurkaip1
aurora kinase A interacting protein 1
chr8_+_119612747 0.40 ENSMUST00000098361.2
Adad2
adenosine deaminase domain containing 2
chr11_-_42000284 0.40 ENSMUST00000109292.2
ENSMUST00000109290.1
Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr11_+_70562898 0.39 ENSMUST00000102559.4
Mink1
misshapen-like kinase 1 (zebrafish)
chr12_-_31950535 0.39 ENSMUST00000172314.2
Hbp1
high mobility group box transcription factor 1
chr16_-_88056176 0.36 ENSMUST00000072256.5
ENSMUST00000023652.8
ENSMUST00000114137.1
Grik1
glutamate receptor, ionotropic, kainate 1
chr3_-_135608221 0.36 ENSMUST00000132668.1
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
chr11_+_75532127 0.35 ENSMUST00000127226.1
Slc43a2
solute carrier family 43, member 2
chr9_-_69760924 0.34 ENSMUST00000071281.4
Foxb1
forkhead box B1
chrX_+_99003224 0.32 ENSMUST00000149999.1
Stard8
START domain containing 8
chr18_+_61555258 0.32 ENSMUST00000165123.1
Csnk1a1
casein kinase 1, alpha 1
chrX_+_137049586 0.30 ENSMUST00000047852.7
Fam199x
family with sequence similarity 199, X-linked
chr1_+_71652837 0.30 ENSMUST00000097699.2
Apol7d
apolipoprotein L 7d
chr7_+_141328122 0.30 ENSMUST00000133012.1
ENSMUST00000026578.7
Tmem80
transmembrane protein 80
chr18_+_61555308 0.29 ENSMUST00000165721.1
ENSMUST00000115246.2
ENSMUST00000166990.1
ENSMUST00000163205.1
ENSMUST00000170862.1
Csnk1a1
casein kinase 1, alpha 1
chr6_+_120666388 0.28 ENSMUST00000112686.1
Cecr2
cat eye syndrome chromosome region, candidate 2
chr5_-_20882072 0.27 ENSMUST00000118174.1
Phtf2
putative homeodomain transcription factor 2
chr3_+_9250602 0.26 ENSMUST00000155203.1
Zbtb10
zinc finger and BTB domain containing 10
chr1_-_72536930 0.25 ENSMUST00000047786.5
March4
membrane-associated ring finger (C3HC4) 4
chr1_-_119997211 0.24 ENSMUST00000174458.1
Gm101
predicted gene 101
chr12_-_69357120 0.24 ENSMUST00000021368.8
Nemf
nuclear export mediator factor
chr7_+_12881165 0.22 ENSMUST00000144578.1
Zfp128
zinc finger protein 128
chr4_+_117096049 0.20 ENSMUST00000030443.5
Ptch2
patched homolog 2
chr17_-_84187939 0.15 ENSMUST00000060366.6
Zfp36l2
zinc finger protein 36, C3H type-like 2
chr12_+_58211772 0.15 ENSMUST00000110671.2
ENSMUST00000044299.2
Sstr1
somatostatin receptor 1
chr7_-_133123409 0.14 ENSMUST00000170459.1
ENSMUST00000166400.1
Ctbp2
C-terminal binding protein 2
chr2_-_104712122 0.14 ENSMUST00000111118.1
ENSMUST00000028597.3
Tcp11l1
t-complex 11 like 1
chr9_-_108578657 0.12 ENSMUST00000068700.5
Wdr6
WD repeat domain 6
chr4_-_83486178 0.12 ENSMUST00000130626.1
Psip1
PC4 and SFRS1 interacting protein 1
chr9_+_114401076 0.11 ENSMUST00000063042.9
ENSMUST00000111820.2
Glb1
Tmppe
galactosidase, beta 1
transmembrane protein with metallophosphoesterase domain
chr15_-_77970750 0.10 ENSMUST00000100484.4
Eif3d
eukaryotic translation initiation factor 3, subunit D
chr7_-_133122615 0.08 ENSMUST00000167218.1
Ctbp2
C-terminal binding protein 2
chr10_-_99126321 0.07 ENSMUST00000060761.5
Phxr2
per-hexamer repeat gene 2
chr2_-_120563795 0.03 ENSMUST00000055241.6
ENSMUST00000135625.1
Zfp106
zinc finger protein 106
chr17_+_68837062 0.03 ENSMUST00000178545.1
Tmem200c
transmembrane protein 200C
chr5_-_137786651 0.02 ENSMUST00000031740.9
Mepce
methylphosphate capping enzyme
chr10_+_42502030 0.02 ENSMUST00000105500.1
ENSMUST00000019939.5
Snx3
sorting nexin 3
chr4_+_32800246 0.01 ENSMUST00000062802.4
Lyrm2
LYR motif containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Gli2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:1900106 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
1.0 6.1 GO:0003383 apical constriction(GO:0003383)
1.0 2.9 GO:0031959 mineralocorticoid receptor signaling pathway(GO:0031959)
0.9 2.6 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.8 3.1 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.6 2.4 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.4 1.7 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.4 1.2 GO:0006106 fumarate metabolic process(GO:0006106)
0.4 2.4 GO:2001184 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) positive regulation of interleukin-12 secretion(GO:2001184)
0.4 2.3 GO:0018992 germ-line sex determination(GO:0018992)
0.4 1.5 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.4 4.0 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.4 1.1 GO:0060365 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) coronal suture morphogenesis(GO:0060365)
0.3 1.3 GO:0002408 myeloid dendritic cell chemotaxis(GO:0002408)
0.3 0.9 GO:0034443 negative regulation of lipoprotein oxidation(GO:0034443) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.3 2.8 GO:0015705 iodide transport(GO:0015705)
0.2 1.0 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.2 0.7 GO:0006296 base-excision repair, AP site formation(GO:0006285) nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.2 1.8 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.2 1.1 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.2 0.9 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.2 0.6 GO:1901856 negative regulation of cellular respiration(GO:1901856)
0.2 1.4 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.2 0.5 GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.2 1.3 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.2 2.7 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.2 0.7 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.2 1.0 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.2 0.8 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.2 3.5 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.2 1.5 GO:0045945 positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.2 0.6 GO:0050975 sensory perception of touch(GO:0050975)
0.1 4.1 GO:0046457 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.1 0.8 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 3.8 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.1 0.6 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.1 1.8 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 1.1 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 2.7 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 1.4 GO:1904424 regulation of GTP binding(GO:1904424)
0.1 0.4 GO:1903416 response to glycoside(GO:1903416)
0.1 1.0 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.1 0.5 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 0.6 GO:0007296 vitellogenesis(GO:0007296)
0.1 1.0 GO:1901339 regulation of store-operated calcium channel activity(GO:1901339)
0.1 1.3 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.1 8.8 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.1 1.6 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 1.0 GO:0042136 neurotransmitter biosynthetic process(GO:0042136)
0.1 0.3 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 3.4 GO:0007520 myoblast fusion(GO:0007520)
0.1 0.9 GO:0071420 cellular response to histamine(GO:0071420)
0.1 2.6 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.8 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
0.1 0.5 GO:0051081 membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0 1.7 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.0 0.5 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:0009957 epidermal cell fate specification(GO:0009957)
0.0 3.8 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 0.7 GO:0051382 kinetochore assembly(GO:0051382)
0.0 1.1 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 1.0 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 2.0 GO:0006826 iron ion transport(GO:0006826)
0.0 0.1 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.0 0.5 GO:0042407 cristae formation(GO:0042407)
0.0 0.9 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.3 GO:0001842 neural fold formation(GO:0001842)
0.0 0.4 GO:0032229 negative regulation of synaptic transmission, GABAergic(GO:0032229)
0.0 0.6 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.9 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.1 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.0 6.4 GO:0007059 chromosome segregation(GO:0007059)
0.0 0.1 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.6 GO:0032212 positive regulation of telomere maintenance via telomerase(GO:0032212)
0.0 0.7 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 1.6 GO:0006413 translational initiation(GO:0006413)
0.0 0.5 GO:0070534 protein K63-linked ubiquitination(GO:0070534)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 6.1 GO:0033269 internode region of axon(GO:0033269)
0.5 2.7 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.5 1.5 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.3 3.8 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.3 3.4 GO:0072687 meiotic spindle(GO:0072687)
0.3 8.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 1.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.2 1.3 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 0.5 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 1.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.6 GO:0060091 kinocilium(GO:0060091)
0.1 1.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 1.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 1.2 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.1 0.8 GO:0005915 zonula adherens(GO:0005915)
0.1 0.3 GO:0090537 CERF complex(GO:0090537)
0.1 0.5 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.1 0.4 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 0.5 GO:0070652 HAUS complex(GO:0070652)
0.1 0.5 GO:0061617 MICOS complex(GO:0061617)
0.1 2.4 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.7 GO:0055038 melanosome(GO:0042470) pigment granule(GO:0048770) recycling endosome membrane(GO:0055038)
0.0 0.4 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 1.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.5 GO:0031105 septin complex(GO:0031105)
0.0 0.5 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 2.0 GO:0005811 lipid particle(GO:0005811)
0.0 2.4 GO:0000922 spindle pole(GO:0000922)
0.0 2.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 3.1 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.6 2.6 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.5 2.8 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.4 3.5 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.4 4.0 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.4 3.6 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.4 7.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.3 3.8 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.3 1.8 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.3 3.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2 2.4 GO:0051525 NFAT protein binding(GO:0051525)
0.2 1.0 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.2 1.9 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.2 2.7 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 0.7 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.9 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.1 0.7 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.1 0.5 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 1.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 6.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 2.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.5 GO:0070012 oligopeptidase activity(GO:0070012)
0.1 1.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 1.5 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.1 1.0 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.1 0.8 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.2 GO:0008158 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158)
0.1 0.4 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.6 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 0.6 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 1.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 0.5 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.5 GO:0071253 connexin binding(GO:0071253)
0.0 0.9 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 1.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 4.1 GO:0016209 antioxidant activity(GO:0016209)
0.0 2.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)
0.0 0.4 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 1.7 GO:0019003 GDP binding(GO:0019003)
0.0 0.7 GO:0016866 intramolecular transferase activity(GO:0016866)
0.0 1.2 GO:0005158 insulin receptor binding(GO:0005158)
0.0 2.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.4 GO:0019213 deacetylase activity(GO:0019213)
0.0 1.2 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 4.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.1 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.3 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.8 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.1 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.7 GO:0070888 E-box binding(GO:0070888)
0.0 2.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.0 GO:0001515 opioid peptide activity(GO:0001515)
0.0 1.4 GO:0051219 phosphoprotein binding(GO:0051219)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 3.8 PID ARF 3PATHWAY Arf1 pathway
0.1 7.3 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 3.9 PID AURORA A PATHWAY Aurora A signaling
0.1 2.4 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 2.7 PID MYC PATHWAY C-MYC pathway
0.1 2.6 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 1.4 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 1.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 1.1 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 1.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.4 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.8 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.1 PID FGF PATHWAY FGF signaling pathway
0.0 3.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.6 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 6.1 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 3.8 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.2 2.4 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 2.6 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.0 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 1.3 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 1.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 3.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 6.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 0.7 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 1.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.1 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.1 0.6 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 2.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.7 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 2.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.5 REACTOME KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes