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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Gcm2
Z-value: 1.25
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Transcription factors associated with Gcm2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Gcm2 | mm10_v2_chr13_-_41109988_41109988 | 0.25 | 1.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_111691002 Show fit | 7.01 |
ENSMUST00000034435.5
|
chymotrypsinogen B1 |
|
| chr3_-_113258837 Show fit | 4.03 |
ENSMUST00000098673.3
|
amylase 2a5 |
|
| chr11_-_87875524 Show fit | 3.41 |
ENSMUST00000049768.3
|
eosinophil peroxidase |
|
| chr4_-_141825997 Show fit | 2.88 |
ENSMUST00000102481.3
|
chymotrypsin-like elastase family, member 2A |
|
| chr6_+_78425973 Show fit | 2.84 |
ENSMUST00000079926.5
|
regenerating islet-derived 1 |
|
| chr6_-_41314700 Show fit | 2.61 |
ENSMUST00000064324.5
|
trypsin 5 |
|
| chr6_+_41302265 Show fit | 2.18 |
ENSMUST00000031913.4
|
trypsin 4 |
|
| chr1_+_93006328 Show fit | 2.10 |
ENSMUST00000059676.4
|
aquaporin 12 |
|
| chr7_-_142657466 Show fit | 2.03 |
ENSMUST00000097936.2
ENSMUST00000000033.5 |
insulin-like growth factor 2 |
|
| chr7_-_142578139 Show fit | 1.99 |
ENSMUST00000136359.1
|
H19 fetal liver mRNA |
Network of associatons between targets according to the STRING database.
First level regulatory network of Gcm2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.3 | GO:0007586 | digestion(GO:0007586) |
| 0.3 | 4.2 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.5 | 3.7 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 1.1 | 3.4 | GO:0002215 | defense response to nematode(GO:0002215) |
| 0.1 | 2.7 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 0.1 | 2.5 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
| 0.1 | 2.3 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.2 | 2.2 | GO:0046549 | retinal cone cell development(GO:0046549) |
| 0.2 | 2.0 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
| 0.1 | 1.9 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 6.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 6.3 | GO:0000323 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.1 | 3.3 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 2.3 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.2 | 1.9 | GO:0097433 | dense body(GO:0097433) |
| 0.0 | 1.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 1.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.5 | 1.5 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.1 | 1.5 | GO:0005614 | interstitial matrix(GO:0005614) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.8 | 5.9 | GO:0004556 | alpha-amylase activity(GO:0004556) |
| 0.1 | 5.0 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 3.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 3.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 2.9 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 2.3 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.0 | 2.2 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.2 | 2.1 | GO:0050308 | sugar-phosphatase activity(GO:0050308) |
| 0.0 | 2.1 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 5.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 2.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.5 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 1.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.3 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 1.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.1 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 0.9 | PID RAC1 PATHWAY | RAC1 signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.3 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.2 | 4.4 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 2.7 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 2.1 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 2.0 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.0 | 2.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 1.8 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.0 | 1.7 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 1.6 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 1.6 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |