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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Gata5

Z-value: 3.61

Motif logo

Transcription factors associated with Gata5

Gene Symbol Gene ID Gene Info
ENSMUSG00000015627.5 GATA binding protein 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gata5mm10_v2_chr2_-_180334665_1803347040.894.0e-13Click!

Activity profile of Gata5 motif

Sorted Z-values of Gata5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_84980458 39.10 ENSMUST00000028467.5
proteoglycan 2, bone marrow
chr2_+_84988194 37.18 ENSMUST00000028466.5
proteoglycan 3
chr11_-_83286722 33.73 ENSMUST00000163961.2
schlafen family member 14
chr17_+_40811089 32.04 ENSMUST00000024721.7
Rhesus blood group-associated A glycoprotein
chr14_-_51057242 30.33 ENSMUST00000089798.2
ribonuclease, RNase A family, 12 (non-active)
chr1_+_40429563 29.69 ENSMUST00000174335.1
interleukin 1 receptor-like 1
chr4_-_119189949 29.21 ENSMUST00000124626.1
erythroblast membrane-associated protein
chr7_-_99238564 26.10 ENSMUST00000064231.7
monoacylglycerol O-acyltransferase 2
chr7_-_103853199 24.34 ENSMUST00000033229.3
hemoglobin Y, beta-like embryonic chain
chr1_-_132367879 23.53 ENSMUST00000142609.1
transmembrane and coiled-coil domains 2
chr11_+_32276400 23.25 ENSMUST00000020531.2
hemoglobin X, alpha-like embryonic chain in Hba complex
chr11_+_32276893 22.27 ENSMUST00000145569.1
hemoglobin X, alpha-like embryonic chain in Hba complex
chr6_+_41354105 21.28 ENSMUST00000072103.5
trypsin 10
chr17_-_28560704 21.09 ENSMUST00000114785.1
ENSMUST00000025062.3
colipase, pancreatic
chr8_+_84701430 20.73 ENSMUST00000037165.4
lymphoblastomic leukemia 1
chr4_-_119190005 19.50 ENSMUST00000138395.1
ENSMUST00000156746.1
erythroblast membrane-associated protein
chr9_+_21029373 18.95 ENSMUST00000001040.5
intercellular adhesion molecule 4, Landsteiner-Wiener blood group
chr17_-_26199008 18.80 ENSMUST00000142410.1
ENSMUST00000120333.1
ENSMUST00000039113.7
protein disulfide isomerase associated 2
chr4_-_137430517 17.70 ENSMUST00000102522.4
chymotrypsin-like elastase family, member 3B
chr13_+_108316332 17.36 ENSMUST00000051594.5
DEP domain containing 1B
chr11_+_70639118 17.24 ENSMUST00000055184.6
ENSMUST00000108551.2
glycoprotein 1b, alpha polypeptide
chr14_+_70457447 17.08 ENSMUST00000003561.3
phytanoyl-CoA hydroxylase interacting protein
chr8_-_85380964 16.68 ENSMUST00000122452.1
myosin light chain kinase 3
chr5_-_73191848 16.38 ENSMUST00000176910.1
furry homolog-like (Drosophila)
chr6_-_41314700 16.01 ENSMUST00000064324.5
trypsin 5
chr15_-_103251465 15.41 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
nuclear factor, erythroid derived 2
chr11_+_58948890 14.31 ENSMUST00000078267.3
histone cluster 3, H2ba
chr13_+_108316395 14.30 ENSMUST00000171178.1
DEP domain containing 1B
chr11_-_102469839 13.50 ENSMUST00000103086.3
integrin alpha 2b
chr16_+_32186192 13.37 ENSMUST00000099990.3
brain expressed gene 6
chr7_-_103827922 13.34 ENSMUST00000023934.6
ENSMUST00000153218.1
hemoglobin, beta adult s chain
chr6_-_40585783 12.62 ENSMUST00000177178.1
ENSMUST00000129948.2
ENSMUST00000101491.4
C-type lectin domain family 5, member a
chr6_+_78370877 12.41 ENSMUST00000096904.3
regenerating islet-derived 3 beta
chr11_+_95337012 12.30 ENSMUST00000037502.6
family with sequence similarity 117, member A
chr11_+_116531744 12.23 ENSMUST00000106387.2
ENSMUST00000100201.3
sphingosine kinase 1
chr11_+_116532441 11.79 ENSMUST00000106386.1
ENSMUST00000145737.1
ENSMUST00000155102.1
ENSMUST00000063446.6
sphingosine kinase 1
chr11_+_9191934 11.52 ENSMUST00000042740.6
ATP-binding cassette, sub-family A (ABC1), member 13
chr17_+_34914459 10.89 ENSMUST00000007249.8
solute carrier family 44, member 4
chr4_-_137409777 10.56 ENSMUST00000024200.6
predicted gene 13011
chr10_+_45577811 10.43 ENSMUST00000037044.6
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
chr6_+_41521782 10.28 ENSMUST00000070380.4
protease, serine, 2
chr7_-_127137807 10.26 ENSMUST00000049931.5
sialophorin
chr11_+_32296489 10.08 ENSMUST00000093207.3
hemoglobin alpha, adult chain 2
chr3_+_105870858 9.87 ENSMUST00000164730.1
adenosine A3 receptor
chr6_+_41302265 9.70 ENSMUST00000031913.4
trypsin 4
chr3_-_14778452 9.12 ENSMUST00000094365.4
carbonic anhydrase 1
chr7_-_121074501 9.09 ENSMUST00000047194.2
immunoglobulin superfamily, member 6
chr13_-_62371936 8.54 ENSMUST00000107989.3
predicted gene 3604
chr7_+_18718075 7.70 ENSMUST00000108481.1
ENSMUST00000051973.8
pregnancy-specific glycoprotein 22
chr3_-_14808358 7.56 ENSMUST00000181860.1
ENSMUST00000144327.2
carbonic anhydrase 1
chr7_+_17087934 7.40 ENSMUST00000152671.1
pregnancy specific glycoprotein 16
chr14_+_61309753 6.84 ENSMUST00000055159.7
ADP-ribosylation factor-like 11
chr11_-_87359011 6.68 ENSMUST00000055438.4
protein phosphatase 1E (PP2C domain containing)
chr2_-_73452666 6.66 ENSMUST00000151939.1
WAS/WASL interacting protein family, member 1
chr11_-_8950539 6.66 ENSMUST00000178195.1
polycystic kidney disease 1 like 1
chr3_-_107221722 6.64 ENSMUST00000029504.8
chymosin
chr7_-_133702515 6.56 ENSMUST00000153698.1
uroporphyrinogen III synthase
chr13_-_62520451 6.27 ENSMUST00000082203.6
ENSMUST00000101547.4
zinc finger protein 934
chr2_+_152427639 6.22 ENSMUST00000128737.1
RIKEN cDNA 6820408C15 gene
chrX_-_8145713 6.12 ENSMUST00000115615.2
ENSMUST00000115616.1
ENSMUST00000115621.2
RNA binding motif protein 3
chr2_+_72476159 6.06 ENSMUST00000102691.4
cell division cycle associated 7
chr2_+_72476225 6.00 ENSMUST00000157019.1
cell division cycle associated 7
chr4_+_103143052 5.92 ENSMUST00000106855.1
mesoderm induction early response 1 homolog (Xenopus laevis
chr9_+_53771499 5.59 ENSMUST00000048670.8
solute carrier family 35, member F2
chr7_-_30072801 5.59 ENSMUST00000183115.1
ENSMUST00000182919.1
ENSMUST00000183190.1
ENSMUST00000080834.8
zinc finger protein 82
chr1_-_170927540 5.58 ENSMUST00000162136.1
ENSMUST00000162887.1
Fc receptor-like A
chr4_-_154928187 5.44 ENSMUST00000123514.1
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
chr17_+_17316078 5.43 ENSMUST00000105311.3
predicted gene 6712
chr8_+_21734490 5.36 ENSMUST00000080533.5
defensin, alpha, 24
chr17_+_48346465 5.34 ENSMUST00000113237.3
triggering receptor expressed on myeloid cells 2
chr5_-_113830422 5.28 ENSMUST00000100874.4
selectin, platelet (p-selectin) ligand
chr9_+_124101944 5.27 ENSMUST00000171719.1
chemokine (C-C motif) receptor 2
chr14_+_75455957 5.21 ENSMUST00000164848.1
seven in absentia homolog 3 (Drosophila)
chr17_+_27342453 5.14 ENSMUST00000151398.1
predicted gene 10505
chr2_+_4559742 5.03 ENSMUST00000176828.1
FERM domain containing 4A
chr16_-_44558879 4.98 ENSMUST00000114634.1
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr13_-_62777089 4.94 ENSMUST00000167516.2
predicted gene 5141
chr12_-_27342696 4.93 ENSMUST00000079063.5
SRY-box containing gene 11
chr12_-_113307912 4.89 ENSMUST00000103418.1
immunoglobulin heavy constant gamma 2B
chr7_+_126862431 4.76 ENSMUST00000132808.1
HIRA interacting protein 3
chr12_+_83520436 4.69 ENSMUST00000021645.7
DDB1 and CUL4 associated factor 4
chr3_+_105870898 4.68 ENSMUST00000010279.5
adenosine A3 receptor
chr13_-_100317674 4.65 ENSMUST00000118574.1
NLR family, apoptosis inhibitory protein 6
chr11_-_101551837 4.43 ENSMUST00000017290.4
breast cancer 1
chr19_-_10678001 4.33 ENSMUST00000025647.5
pepsinogen 5, group I
chr17_-_24527830 4.30 ENSMUST00000176353.1
ENSMUST00000176237.1
TNF receptor-associated factor 7
chr15_-_95528702 4.21 ENSMUST00000166170.1
NEL-like 2
chr2_+_32525013 4.20 ENSMUST00000150621.1
predicted gene 13412
chr2_+_167062934 4.11 ENSMUST00000125674.1
RIKEN cDNA 1500012F01 gene
chr1_+_135232045 3.95 ENSMUST00000110798.3
predicted gene 4204
chr4_+_119637704 3.94 ENSMUST00000024015.2
guanylate cyclase activator 2a (guanylin)
chr10_+_79988584 3.72 ENSMUST00000004784.4
ENSMUST00000105374.1
calponin 2
chr17_+_25369267 3.70 ENSMUST00000160377.1
ENSMUST00000160485.1
tryptase gamma 1
chr3_+_4211716 3.70 ENSMUST00000170943.1
predicted gene 8775
chr1_-_136346074 3.54 ENSMUST00000048309.6
calmodulin regulated spectrin-associated protein family, member 2
chr4_+_6191093 3.42 ENSMUST00000029907.5
UBX domain protein 2B
chr15_-_86186136 3.41 ENSMUST00000044332.9
ceramide kinase
chr11_+_94936224 3.37 ENSMUST00000001547.7
collagen, type I, alpha 1
chr6_+_34384218 3.36 ENSMUST00000038383.7
ENSMUST00000115051.1
aldo-keto reductase family 1, member B10 (aldose reductase)
chr17_+_45523416 3.28 ENSMUST00000113547.1
t-complex-associated testis expressed 1
chr6_+_48904979 3.27 ENSMUST00000162948.1
ENSMUST00000167529.1
amine oxidase, copper-containing 1
chr2_+_150323702 3.26 ENSMUST00000133235.2
predicted gene 10130
chr11_-_45955183 3.24 ENSMUST00000109254.1
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr11_+_4986824 2.95 ENSMUST00000009234.9
ENSMUST00000109897.1
adaptor protein complex AP-1, beta 1 subunit
chr7_+_101361997 2.92 ENSMUST00000133423.1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chrX_-_139998519 2.86 ENSMUST00000113007.1
ENSMUST00000033810.7
ENSMUST00000113011.2
ENSMUST00000087400.5
RNA binding motif protein 41
chr10_+_100488289 2.85 ENSMUST00000164751.1
centrosomal protein 290
chr1_+_85600672 2.79 ENSMUST00000080204.4
Sp140 nuclear body protein
chr6_+_29279587 2.61 ENSMUST00000167131.1
family with sequence similarity 71, member F2
chr3_+_146121655 2.56 ENSMUST00000039450.4
mucolipin 3
chr11_-_118125944 2.49 ENSMUST00000124164.1
dynein, axonemal, heavy chain 17
chr7_+_28833975 2.47 ENSMUST00000066723.8
lectin, galactose binding, soluble 4
chr1_-_85270543 2.43 ENSMUST00000093506.5
ENSMUST00000064341.8
RIKEN cDNA C130026I21 gene
chr12_-_69893162 2.34 ENSMUST00000049239.7
ENSMUST00000110570.1
mitogen-activated protein kinase kinase kinase kinase 5
chr1_+_51289106 2.28 ENSMUST00000051572.6
serum deprivation response
chr6_-_54566484 2.13 ENSMUST00000019268.4
secernin 1
chr15_+_100154379 2.10 ENSMUST00000023768.6
ENSMUST00000108971.2
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr15_+_6299797 2.10 ENSMUST00000159046.1
ENSMUST00000161040.1
disabled 2, mitogen-responsive phosphoprotein
chr9_-_41004599 1.98 ENSMUST00000180384.1
cytotoxic and regulatory T cell molecule
chr7_+_45621805 1.83 ENSMUST00000033100.4
izumo sperm-egg fusion 1
chr8_-_12573311 1.78 ENSMUST00000180858.1
RIKEN cDNA D630011A20 gene
chr7_-_126861648 1.71 ENSMUST00000129812.1
ENSMUST00000106342.1
INO80 complex subunit E
chr2_+_10370494 1.68 ENSMUST00000114862.1
ENSMUST00000114861.1
Scm-like with four mbt domains 2
chr2_-_25224653 1.65 ENSMUST00000043584.4
tubulin, beta 4B class IVB
chr16_+_36934976 1.64 ENSMUST00000023531.8
hematopoietic cell specific Lyn substrate 1
chr3_-_93015669 1.60 ENSMUST00000107301.1
ENSMUST00000029521.4
cysteine-rich C-terminal 1
chr9_+_110798160 1.49 ENSMUST00000035715.6
protease, serine, 42
chr2_+_154656959 1.48 ENSMUST00000044277.9
charged multivesicular body protein 4B
chr3_-_146839365 1.45 ENSMUST00000084614.3
predicted gene 10288
chr5_+_87808082 1.41 ENSMUST00000072539.5
ENSMUST00000113279.1
ENSMUST00000101057.3
casein alpha s2-like B
chr7_-_126861828 1.40 ENSMUST00000106343.1
INO80 complex subunit E
chr6_+_81923645 1.39 ENSMUST00000043195.4
GC-rich sequence DNA binding factor 2
chr7_-_23947237 1.37 ENSMUST00000086013.2
predicted gene 10175
chr13_-_100201961 1.30 ENSMUST00000167986.2
ENSMUST00000117913.1
NLR family, apoptosis inhibitory protein 2
chrX_+_166238901 1.28 ENSMUST00000112235.1
glycoprotein m6b
chr7_-_14123042 1.28 ENSMUST00000098809.2
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 3
chr10_-_130127055 1.27 ENSMUST00000074161.1
olfactory receptor 824
chr4_-_11981265 1.23 ENSMUST00000098260.2
predicted gene 10604
chr11_+_70017199 1.21 ENSMUST00000133140.1
discs, large homolog 4 (Drosophila)
chr15_+_39745926 1.20 ENSMUST00000022913.4
dentrocyte expressed seven transmembrane protein
chr11_-_109995743 1.20 ENSMUST00000106669.2
ATP-binding cassette, sub-family A (ABC1), member 8b
chrX_-_37110257 1.17 ENSMUST00000076265.6
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr9_+_38877126 1.10 ENSMUST00000078289.2
olfactory receptor 926
chr6_+_135011609 1.10 ENSMUST00000032326.4
ENSMUST00000130851.1
ENSMUST00000154558.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
chr8_+_19682268 1.04 ENSMUST00000153710.1
ENSMUST00000127799.1
predicted gene 6483
chr7_-_135528645 1.03 ENSMUST00000053716.7
clarin 3
chr12_+_69241832 1.02 ENSMUST00000063445.6
kelch domain containing 1
chr9_-_58201705 1.01 ENSMUST00000163200.1
ENSMUST00000165276.1
immunoglobulin superfamily containing leucine-rich repeat 2
chr11_-_109995775 1.00 ENSMUST00000020948.8
ATP-binding cassette, sub-family A (ABC1), member 8b
chr1_+_71652837 1.00 ENSMUST00000097699.2
apolipoprotein L 7d
chr6_-_34317442 0.99 ENSMUST00000154655.1
ENSMUST00000102980.4
aldo-keto reductase family 1, member B3 (aldose reductase)
chr2_+_164698501 0.99 ENSMUST00000017454.7
serine protease inhibitor, Kunitz type 4
chr11_+_90030295 0.97 ENSMUST00000092788.3
transmembrane protein 100
chr8_+_20136455 0.94 ENSMUST00000179299.1
ENSMUST00000096485.4
predicted gene, 21811
chr2_+_71786923 0.91 ENSMUST00000112101.1
ENSMUST00000028522.3
integrin alpha 6
chr7_-_18532225 0.89 ENSMUST00000094795.4
pregnancy-specific glycoprotein 25
chr12_+_95692212 0.88 ENSMUST00000057324.3
fibronectin leucine rich transmembrane protein 2
chr3_+_95427575 0.86 ENSMUST00000181809.1
predicted gene 4349
chr13_+_3837757 0.86 ENSMUST00000042219.4
calmodulin 4
chr3_-_95106907 0.84 ENSMUST00000107233.2
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
chr16_+_92612755 0.82 ENSMUST00000180989.1
predicted gene, 26626
chr15_-_77153772 0.82 ENSMUST00000166610.1
ENSMUST00000111581.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chrX_-_134111852 0.80 ENSMUST00000033610.6
NADPH oxidase 1
chr16_+_57549232 0.79 ENSMUST00000159414.1
filamin A interacting protein 1-like
chr19_-_38819156 0.79 ENSMUST00000025963.7
nucleolar complex associated 3 homolog (S. cerevisiae)
chr18_+_7869707 0.78 ENSMUST00000166062.1
ENSMUST00000169010.1
WW domain containing adaptor with coiled-coil
chrX_-_134111708 0.78 ENSMUST00000159259.1
ENSMUST00000113275.3
NADPH oxidase 1
chrX_-_37104523 0.76 ENSMUST00000130324.1
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr4_-_106727930 0.76 ENSMUST00000106770.1
ENSMUST00000145044.1
maestro heat-like repeat family member 7
chrX_+_112495266 0.73 ENSMUST00000026602.2
ENSMUST00000113412.2
RIKEN cDNA 2010106E10 gene
chr2_-_7081207 0.71 ENSMUST00000114923.2
ENSMUST00000182706.1
CUGBP, Elav-like family member 2
chr2_-_7081256 0.70 ENSMUST00000183209.1
CUGBP, Elav-like family member 2
chr12_-_103425780 0.67 ENSMUST00000110001.2
ENSMUST00000044923.7
DEAD (Asp-Glu-Ala-Asp) box polypeptide 24
chr17_+_74489492 0.63 ENSMUST00000024873.6
Yip1 domain family, member 4
chr14_-_101200069 0.53 ENSMUST00000057718.4
RIKEN cDNA 1700110M21 gene
chr14_-_52036143 0.45 ENSMUST00000052560.4
olfactory receptor 221
chrX_+_52988119 0.41 ENSMUST00000026723.8
hypoxanthine guanine phosphoribosyl transferase
chr7_-_46672537 0.31 ENSMUST00000049298.7
tryptophan hydroxylase 1
chr4_-_59438633 0.31 ENSMUST00000040166.7
ENSMUST00000107544.1
sushi domain containing 1
chr11_+_87853207 0.30 ENSMUST00000038196.6
Meckel syndrome, type 1
chr6_-_147243794 0.30 ENSMUST00000153786.1
predicted gene 15767
chr12_-_112674193 0.28 ENSMUST00000001780.3
thymoma viral proto-oncogene 1
chr7_+_104003259 0.20 ENSMUST00000098184.1
olfactory receptor 638
chr19_-_29523159 0.19 ENSMUST00000180986.1
RIKEN cDNA A930007I19 gene
chr1_+_172376528 0.18 ENSMUST00000052455.2
phosphatidylinositol glycan anchor biosynthesis, class M
chr15_+_73834561 0.12 ENSMUST00000154520.1
predicted gene 6569

Network of associatons between targets according to the STRING database.

First level regulatory network of Gata5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
13.0 39.1 GO:0002215 defense response to nematode(GO:0002215)
10.7 32.0 GO:0072488 ammonium transmembrane transport(GO:0072488)
9.3 37.2 GO:0045575 basophil activation(GO:0045575)
8.7 69.8 GO:0015671 oxygen transport(GO:0015671)
8.7 26.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462)
4.0 24.0 GO:0019371 cyclooxygenase pathway(GO:0019371)
3.6 10.9 GO:0008292 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
3.4 10.3 GO:0002865 regulation of type IV hypersensitivity(GO:0001807) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) negative regulation of hypersensitivity(GO:0002884)
3.0 20.7 GO:0001955 blood vessel maturation(GO:0001955)
2.7 27.2 GO:0002826 negative regulation of T-helper 1 type immune response(GO:0002826)
2.3 13.6 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
2.2 6.7 GO:0003127 detection of nodal flow(GO:0003127) detection of endogenous stimulus(GO:0009726)
1.9 7.7 GO:2001201 regulation of transforming growth factor-beta secretion(GO:2001201)
1.9 33.7 GO:0016075 rRNA catabolic process(GO:0016075)
1.8 5.3 GO:0002582 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
1.8 5.3 GO:1902567 immune complex clearance(GO:0002434) immune complex clearance by monocytes and macrophages(GO:0002436) astrocyte chemotaxis(GO:0035700) regulation of immune complex clearance by monocytes and macrophages(GO:0090264) positive regulation of immune complex clearance by monocytes and macrophages(GO:0090265) negative regulation of eosinophil activation(GO:1902567) positive regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000451) regulation of astrocyte chemotaxis(GO:2000458)
1.6 6.6 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780)
1.6 16.4 GO:0090527 actin filament reorganization(GO:0090527)
1.5 4.4 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
1.5 14.6 GO:0002349 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
1.3 15.4 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
1.2 4.9 GO:0061386 closure of optic fissure(GO:0061386)
1.0 5.2 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
1.0 1.0 GO:0051595 response to methylglyoxal(GO:0051595)
1.0 4.9 GO:0016068 regulation of type I hypersensitivity(GO:0001810) positive regulation of type I hypersensitivity(GO:0001812) type I hypersensitivity(GO:0016068)
0.7 17.2 GO:0042730 fibrinolysis(GO:0042730)
0.7 2.0 GO:0002355 detection of tumor cell(GO:0002355)
0.6 10.3 GO:0031000 response to caffeine(GO:0031000)
0.6 12.6 GO:0033033 negative regulation of myeloid cell apoptotic process(GO:0033033)
0.6 5.5 GO:1903208 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.6 20.4 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175)
0.6 3.4 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.5 5.4 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.5 21.4 GO:0032094 response to food(GO:0032094)
0.5 5.9 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.4 6.7 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.4 6.0 GO:0070269 pyroptosis(GO:0070269)
0.4 4.9 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.4 16.7 GO:0006730 one-carbon metabolic process(GO:0006730)
0.4 4.2 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.3 2.1 GO:0035026 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026)
0.3 4.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.3 20.5 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.3 1.2 GO:0034241 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241)
0.3 36.1 GO:0007586 digestion(GO:0007586)
0.3 3.3 GO:0071280 cellular response to copper ion(GO:0071280)
0.2 10.1 GO:0048821 erythrocyte development(GO:0048821)
0.2 6.7 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.2 1.3 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of serotonin uptake(GO:0051612)
0.2 31.7 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.2 0.8 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.2 3.7 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.2 0.9 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.2 5.4 GO:0019731 antibacterial humoral response(GO:0019731)
0.2 13.5 GO:0070527 platelet aggregation(GO:0070527)
0.2 1.8 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.2 1.0 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.2 0.3 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.1 6.1 GO:0009409 response to cold(GO:0009409)
0.1 10.4 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 2.7 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.1 0.4 GO:0046098 purine nucleobase salvage(GO:0043096) guanine metabolic process(GO:0046098) hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.1 3.0 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 5.0 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.1 1.6 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
0.1 14.3 GO:0006334 nucleosome assembly(GO:0006334)
0.1 5.0 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 1.2 GO:0098970 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.1 0.9 GO:0035878 nail development(GO:0035878)
0.1 2.9 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 6.2 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 1.9 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 3.2 GO:0006400 tRNA modification(GO:0006400)
0.0 2.5 GO:0003341 cilium movement(GO:0003341)
0.0 0.3 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.0 1.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 1.8 GO:0006672 ceramide metabolic process(GO:0006672)
0.0 0.8 GO:0097178 ruffle assembly(GO:0097178)
0.0 3.6 GO:0006869 lipid transport(GO:0006869)
0.0 2.1 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 4.4 GO:0008380 RNA splicing(GO:0008380)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
11.7 93.3 GO:0005833 hemoglobin complex(GO:0005833)
1.2 15.5 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
1.1 3.4 GO:0005584 collagen type I trimer(GO:0005584)
0.9 6.0 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.7 17.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.7 4.4 GO:0070531 BRCA1-A complex(GO:0070531)
0.7 3.5 GO:0036449 microtubule minus-end(GO:0036449)
0.5 2.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.4 12.2 GO:0042588 zymogen granule(GO:0042588)
0.3 1.4 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.3 14.4 GO:0008305 integrin complex(GO:0008305)
0.3 1.0 GO:0097454 Schwann cell microvillus(GO:0097454)
0.3 1.6 GO:0071438 invadopodium membrane(GO:0071438)
0.3 4.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 3.1 GO:0031011 Ino80 complex(GO:0031011)
0.2 4.7 GO:0005682 U5 snRNP(GO:0005682)
0.2 3.2 GO:0036038 MKS complex(GO:0036038)
0.2 14.3 GO:0000786 nucleosome(GO:0000786)
0.2 2.5 GO:0036157 outer dynein arm(GO:0036157)
0.2 1.6 GO:0045298 tubulin complex(GO:0045298)
0.1 1.5 GO:0000815 ESCRT III complex(GO:0000815)
0.1 2.9 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 16.3 GO:0072562 blood microparticle(GO:0072562)
0.1 14.2 GO:0032993 protein-DNA complex(GO:0032993)
0.1 25.2 GO:0008021 synaptic vesicle(GO:0008021)
0.1 6.7 GO:0034704 calcium channel complex(GO:0034704)
0.1 5.0 GO:0044295 axonal growth cone(GO:0044295)
0.1 29.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 3.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 1.8 GO:0002080 acrosomal membrane(GO:0002080)
0.1 1.9 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 5.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 16.4 GO:0005938 cell cortex(GO:0005938)
0.0 6.8 GO:0005923 bicellular tight junction(GO:0005923)
0.0 23.0 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 6.1 GO:0015934 large ribosomal subunit(GO:0015934)
0.0 1.7 GO:0016235 aggresome(GO:0016235)
0.0 0.7 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 46.0 GO:0005615 extracellular space(GO:0005615)
0.0 2.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 7.9 GO:0009986 cell surface(GO:0009986)
0.0 7.0 GO:0016324 apical plasma membrane(GO:0016324)
0.0 34.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 12.6 GO:0031410 cytoplasmic vesicle(GO:0031410)
0.0 10.6 GO:0005730 nucleolus(GO:0005730)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.9 29.7 GO:0002113 interleukin-33 binding(GO:0002113)
9.4 37.7 GO:0031721 hemoglobin alpha binding(GO:0031721)
7.6 45.5 GO:0005344 oxygen transporter activity(GO:0005344)
5.2 26.1 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
5.0 10.1 GO:0031720 haptoglobin binding(GO:0031720)
3.4 24.0 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
2.7 13.5 GO:0070051 fibrinogen binding(GO:0070051)
2.4 16.7 GO:0004687 myosin light chain kinase activity(GO:0004687)
2.1 16.7 GO:0004064 arylesterase activity(GO:0004064)
1.8 5.3 GO:0035717 chemokine (C-C motif) ligand 7 binding(GO:0035717)
1.7 18.8 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
1.7 32.0 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
1.6 10.9 GO:0015220 choline transmembrane transporter activity(GO:0015220)
1.3 14.6 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
1.1 3.4 GO:0001729 ceramide kinase activity(GO:0001729)
1.1 3.4 GO:0070401 NADP+ binding(GO:0070401)
1.1 6.6 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
1.1 3.2 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
1.0 7.7 GO:0045545 syndecan binding(GO:0045545)
0.8 3.9 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.7 6.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.6 5.3 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.5 12.6 GO:0001618 virus receptor activity(GO:0001618)
0.5 32.2 GO:0004521 endoribonuclease activity(GO:0004521)
0.5 30.3 GO:0004540 ribonuclease activity(GO:0004540)
0.4 3.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.4 11.0 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.4 3.5 GO:0051011 microtubule minus-end binding(GO:0051011)
0.4 2.5 GO:0016936 galactoside binding(GO:0016936)
0.3 70.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 15.4 GO:0050699 WW domain binding(GO:0050699)
0.3 1.6 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.3 84.2 GO:0030246 carbohydrate binding(GO:0030246)
0.3 2.9 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.2 3.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 4.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.2 1.8 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.2 2.9 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.2 1.3 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
0.2 10.3 GO:0030544 Hsp70 protein binding(GO:0030544)
0.2 22.0 GO:0005178 integrin binding(GO:0005178)
0.2 2.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 5.4 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 1.2 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 1.0 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 10.4 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 5.9 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 6.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 0.8 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 6.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 2.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 28.4 GO:0005096 GTPase activator activity(GO:0005096)
0.1 0.3 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 4.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 4.4 GO:0003684 damaged DNA binding(GO:0003684)
0.1 14.9 GO:0008047 enzyme activator activity(GO:0008047)
0.1 4.5 GO:0005080 protein kinase C binding(GO:0005080)
0.1 0.9 GO:0045499 chemorepellent activity(GO:0045499)
0.1 6.7 GO:0005262 calcium channel activity(GO:0005262)
0.0 8.3 GO:0017124 SH3 domain binding(GO:0017124)
0.0 6.8 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 1.4 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 4.8 GO:0030674 protein binding, bridging(GO:0030674)
0.0 3.0 GO:0008565 protein transporter activity(GO:0008565)
0.0 1.6 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.8 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 8.7 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 2.6 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 76.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
1.1 36.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.9 24.0 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.7 10.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.6 14.4 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.3 26.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.2 5.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.4 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 8.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 3.4 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.1 5.3 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 12.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 24.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 14.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.2 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.8 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 2.3 PID TNF PATHWAY TNF receptor signaling pathway
0.0 2.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.6 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.7 PID TGFBR PATHWAY TGF-beta receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 15.6 REACTOME DEFENSINS Genes involved in Defensins
1.4 20.6 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
1.3 42.9 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.8 13.5 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.7 14.6 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.5 24.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.5 21.1 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.4 20.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3 10.3 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.3 2.1 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.2 4.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 3.0 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 5.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.2 4.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.6 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 30.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 5.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 5.7 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 1.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.8 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 2.9 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones