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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Ezh2_Atf2_Ikzf1
Z-value: 1.55
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Transcription factors associated with Ezh2_Atf2_Ikzf1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000029687.10 | enhancer of zeste 2 polycomb repressive complex 2 subunit | |
| ENSMUSG00000027104.12 | activating transcription factor 2 | |
| ENSMUSG00000018654.11 | IKAROS family zinc finger 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ikzf1 | mm10_v2_chr11_+_11685909_11685947 | -0.60 | 9.7e-05 | Click! |
| Ezh2 | mm10_v2_chr6_-_47594967_47595047 | -0.53 | 7.9e-04 | Click! |
| Atf2 | mm10_v2_chr2_-_73892619_73892639 | 0.04 | 8.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_55175019 Show fit | 17.93 |
ENSMUST00000003569.5
|
indolethylamine N-methyltransferase |
|
| chr19_-_40073731 Show fit | 8.42 |
ENSMUST00000048959.3
|
cytochrome P450, family 2, subfamily c, polypeptide 54 |
|
| chr2_+_67748212 Show fit | 6.35 |
ENSMUST00000180887.1
|
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 |
|
| chr6_+_34746368 Show fit | 6.14 |
ENSMUST00000142716.1
|
caldesmon 1 |
|
| chr19_+_39287074 Show fit | 6.09 |
ENSMUST00000003137.8
|
cytochrome P450, family 2, subfamily c, polypeptide 29 |
|
| chr6_+_125321205 Show fit | 5.57 |
ENSMUST00000176365.1
|
sodium channel, nonvoltage-gated 1 alpha |
|
| chr5_-_92328068 Show fit | 4.98 |
ENSMUST00000113093.3
|
chemokine (C-X-C motif) ligand 9 |
|
| chr19_+_39007019 Show fit | 4.83 |
ENSMUST00000025966.4
|
cytochrome P450, family 2, subfamily c, polypeptide 55 |
|
| chr6_+_34745952 Show fit | 4.72 |
ENSMUST00000123823.1
ENSMUST00000136907.1 ENSMUST00000126181.1 |
caldesmon 1 |
|
| chr15_+_10215955 Show fit | 4.58 |
ENSMUST00000130720.1
|
prolactin receptor |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ezh2_Atf2_Ikzf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 17.5 | GO:0043651 | linoleic acid metabolic process(GO:0043651) |
| 0.6 | 17.3 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.1 | 14.0 | GO:0009636 | response to toxic substance(GO:0009636) |
| 0.2 | 10.9 | GO:0050891 | multicellular organismal water homeostasis(GO:0050891) |
| 1.5 | 8.8 | GO:0038161 | prolactin signaling pathway(GO:0038161) |
| 0.1 | 7.7 | GO:0006940 | regulation of smooth muscle contraction(GO:0006940) |
| 0.2 | 7.1 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.2 | 6.9 | GO:0046688 | response to copper ion(GO:0046688) |
| 0.7 | 6.0 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
| 0.5 | 5.9 | GO:0005513 | detection of calcium ion(GO:0005513) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 14.3 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.5 | 12.0 | GO:0034706 | sodium channel complex(GO:0034706) |
| 1.3 | 11.3 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 7.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 6.8 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 6.5 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.3 | 6.4 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.3 | 5.9 | GO:0031045 | dense core granule(GO:0031045) |
| 0.2 | 5.5 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 17.9 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 4.4 | 17.5 | GO:0071614 | linoleic acid epoxygenase activity(GO:0071614) |
| 0.1 | 14.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.1 | 11.7 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.4 | 10.1 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 1.8 | 8.8 | GO:0004925 | prolactin receptor activity(GO:0004925) |
| 1.2 | 7.3 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 1.6 | 6.3 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
| 1.5 | 5.9 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.6 | 5.8 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 9.9 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 7.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 7.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 6.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 5.9 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 5.8 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 5.1 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 3.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 3.5 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 10.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.4 | 8.9 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.8 | 6.6 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.3 | 6.2 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.5 | 6.1 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.2 | 6.1 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.3 | 4.9 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.3 | 4.4 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 4.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |