ISMARA results: Esrrb

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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Esrrb_Esrra

Z-value: 0.94

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Transcription factors associated with Esrrb_Esrra

Gene Symbol	Gene ID	Gene Info
Esrrb Ensembl NCBI MGI UniProt	ENSMUSG00000021255.11	estrogen related receptor, beta
Esrra Ensembl NCBI MGI UniProt	ENSMUSG00000024955.7	estrogen related receptor, alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Esrra	mm10_v2_chr19_-_6921804_6921834	0.52	1.1e-03	Click!
Esrrb	mm10_v2_chr12_+_86361112_86361131	0.17	3.3e-01	Click!

Activity profile of Esrrb_Esrra motif

Sorted Z-values of Esrrb_Esrra motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_43524462 Show fit	2.85	ENSMUST00000026196.7	Got1 Ensembl NCBI MGI UniProt Show fit	glutamate oxaloacetate transaminase 1, soluble
chr8_-_104624266 Show fit	1.92	ENSMUST00000163783.2	Cdh16 Ensembl NCBI MGI UniProt Show fit	cadherin 16
chr4_+_34893772 Show fit	1.86	ENSMUST00000029975.3 ENSMUST00000135871.1 ENSMUST00000108130.1	Cga Ensembl NCBI MGI UniProt Show fit	glycoprotein hormones, alpha subunit
chr7_-_141429351 Show fit	1.77	ENSMUST00000164387.1 ENSMUST00000137488.1 ENSMUST00000084436.3	Cend1 Ensembl NCBI MGI UniProt Show fit	cell cycle exit and neuronal differentiation 1
chr2_-_28563362 Show fit	1.71	ENSMUST00000028161.5	Cel Ensembl NCBI MGI UniProt Show fit	carboxyl ester lipase
chr3_-_20275659 Show fit	1.58	ENSMUST00000011607.5	Cpb1 Ensembl NCBI MGI UniProt Show fit	carboxypeptidase B1 (tissue)
chrX_-_8018492 Show fit	1.49	ENSMUST00000033503.2	Glod5 Ensembl NCBI MGI UniProt Show fit	glyoxalase domain containing 5
chr11_+_3989924 Show fit	1.43	ENSMUST00000109981.1	Gal3st1 Ensembl NCBI MGI UniProt Show fit	galactose-3-O-sulfotransferase 1
chr7_-_142576492 Show fit	1.37	ENSMUST00000140716.1	H19 Ensembl NCBI MGI UniProt Show fit	H19 fetal liver mRNA
chr1_+_72824482 Show fit	1.36	ENSMUST00000047328.4	Igfbp2 Ensembl NCBI MGI UniProt Show fit	insulin-like growth factor binding protein 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Esrrb_Esrra

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	3.2	GO:0006106	fumarate metabolic process(GO:0006106)
0.9	2.8	GO:0021933	radial glia guided migration of cerebellar granule cell(GO:0021933)
0.1	2.0	GO:0006707	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1	1.9	GO:0046884	follicle-stimulating hormone secretion(GO:0046884)
0.1	1.9	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0	1.9	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0	1.9	GO:0032091	negative regulation of protein binding(GO:0032091)
0.1	1.7	GO:0015985	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2	1.6	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.1	1.6	GO:2000251	positive regulation of actin cytoskeleton reorganization(GO:2000251)

Showing 1 to 10 of 186 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.7	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	2.7	GO:0043679	axon terminus(GO:0043679)
0.1	2.6	GO:0042588	zymogen granule(GO:0042588)
0.0	2.6	GO:0005844	polysome(GO:0005844)
0.3	1.7	GO:0098560	cytoplasmic side of late endosome membrane(GO:0098560)
0.0	1.7	GO:0044455	mitochondrial membrane part(GO:0044455)
0.2	1.6	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750)
0.1	1.6	GO:0071439	clathrin complex(GO:0071439)
0.1	1.5	GO:0005753	mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0	1.4	GO:0015934	large ribosomal subunit(GO:0015934)

Showing 1 to 10 of 62 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.9	GO:0005179	hormone activity(GO:0005179)
0.9	2.8	GO:0080130	L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.6	1.7	GO:0004771	sterol esterase activity(GO:0004771) retinyl-palmitate esterase activity(GO:0050253)
0.4	1.6	GO:0004092	carnitine O-acetyltransferase activity(GO:0004092)
0.3	1.6	GO:0004111	creatine kinase activity(GO:0004111)
0.0	1.6	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.2	1.5	GO:0035473	lipase binding(GO:0035473)
0.4	1.4	GO:0001733	galactosylceramide sulfotransferase activity(GO:0001733)
0.1	1.4	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	1.4	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)

Showing 1 to 10 of 141 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
2.5	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
1.6	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.8	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.6	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.5	PID EPHB FWD PATHWAY	EPHB forward signaling
0.5	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.5	PID BARD1 PATHWAY	BARD1 signaling events
0.4	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.4	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.4	PID PTP1B PATHWAY	Signaling events mediated by PTP1B

Showing 1 to 10 of 17 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.7	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	2.0	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.2	1.8	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.0	1.8	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	1.7	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	1.6	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.1	1.4	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.1	1.3	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.1	1.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	1.0	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)

Showing 1 to 10 of 39 entries

Results for Esrrb_Esrra

Z-value: 0.94

Motif logo

Transcription factors associated with Esrrb_Esrra

Activity-expression correlation:

Activity profile of Esrrb_Esrra motif

Sorted Z-values of Esrrb_Esrra motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Esrrb_Esrra

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: